Protein Alignment Ca-beta and cacnb4b

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001106988.1
• Gene: cacnb4b / 678560
• ZFINID: ZDB-GENE-060421-7907
• Length: 523
• Species: Danio rerio
• Alignment Length: 593
• Identity: 289/593 - (48%)
• Similarity: 355/593 - (59%)
• Gaps: 130/593 - (21%)

  Fly    37 LFTQGSADSNYSQPS-SDLSLDEEK----ESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGA 96
            :..||||||..|:|| ||:||:||:    ...|:|:|:||..||::|::|.|||||:|||:|.||
Zfish    46 ILRQGSADSYTSRPSDSDVSLEEERPEGGSQGRQEREQQAQLQLERAKAKAVAFAVKTNVSYCGA 110

  Fly    97 IDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRL 161
            :|:|.||.|.|:||:.::|||||||::|:|||||||||||::||||||.||:|||.|.:.:.||:
Zfish   111 LDEDVPVPGTAISFDAKDFLHIKEKFNNDWWIGRLVKEGCEIGFIPSPLKLENIRAQLEQKKSRV 175

  Fly   162 YG-TKGSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQET 225
            .| :.||||.:||                      |.|..|           |:|:    |..|.
Zfish   176 QGKSSGSSSSSLG----------------------DVMSSG-----------KQKQ----KVTEH 203

  Fly   226 ASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNP 290
            .:|||||||||||||||||||||||||||||||||||||||:|||.||||.|||||||||::|||
Zfish   204 VAPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRITITRVTADISLAKRSVLNNP 268

  Fly   291 SKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISS 355
            |||||:|||::||. |.:||.||||||||||||||||||.||||||:||.||||||.||::|:||
Zfish   269 SKRAIIERSNTRSS-LAEVQSEIERIFELARSLQLVVLDADTINHPAQLMKTSLAPIIVHVKVSS 332

  Fly   356 SKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATH 420
            .||||||||||||||:|:|:||:|||:|||||||:|||:|||||||||||||:|||||.||||||
Zfish   333 PKVLQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATH 397

  Fly   421 PDIRAVPPIARPLPQEASPSADPARLGP--TPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSR 483
            ..      .:.||......:..||.|.|  |..:.|.:....|..|.....||.....||
Zfish   398 TS------SSTPLNPLLGRNLGPAALAPYTTSAISGLQNQQGQKTRHANHTGDHSTPNER----- 451

  Fly   484 ERERERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSR 548
                   |.....|..::.:|:.|.|.|                            |.:..||
Zfish   452 -------RNLMTSDENYHNERAHKGRNR----------------------------GSSGSQH-- 479

  Fly   549 RQPTSVRHQERGGGVGAGGGGGGVGGGYERDRERERYERRERDLMHYDLNSDELLDERNFEYPAM 613
                                 ||.|..:....|::.|:         |...|.....||
Zfish   480 ---------------------GGSGRDHHYMEEQQGYQ---------DPYQDTYKPHRN------ 508

  Fly   614 RSGPSGAS 621
            ||.|...|
Zfish   509 RSSPGSYS 516

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	22/44 (50%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:395500	151/180 (84%)
cacnb4b	NP_001106988.1	VGCC_beta4Aa_N	50..91	CDD:463445	21/40 (53%)
		SH3	103..162	CDD:473055	40/58 (69%)
		Guanylate_kin	212..392	CDD:395500	151/180 (84%)