Protein Alignment Ca-beta and cacnb1

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_005163865.2
• Gene: cacnb1 / 436925
• ZFINID: ZDB-GENE-040718-399
• Length: 642
• Species: Danio rerio
• Alignment Length: 658
• Identity: 325/658 - (49%)
• Similarity: 397/658 - (60%)
• Gaps: 92/658 - (13%)

  Fly     1 MVQRASSSDAPSV-----------QGGQH-------RESRF--GLGYPSYQSGYNKLFTQGSADS 45
            |||..:.|..||.           ..|.|       |:|||  ..|..|..:..|....||||||
Zfish     1 MVQEGNMSRTPSTSTQEIQMDMFDHHGSHAQGKYAKRKSRFKRSDGSTSSDTTSNSFVRQGSADS 65

  Fly    46 NYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVS 109
            ..|:|| ||:||:|:.|:||:|.:||||:.|:||::|||||||||||.|:...:||.||||.|:|
Zfish    66 YTSRPSDSDVSLEEDPEALRKEADRQALATLEKAKTKPVAFAVRTNVGYNPGPNDDVPVQGMAIS 130

  Fly   110 FEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIR--MQNQTRPSRLYGTKGSSSGNL 172
            ||.::||||||||:|:|||||||||||:|||||||.||::.|  .:.:.|.:||..:|
Zfish   131 FEPKDFLHIKEKYNNDWWIGRLVKEGCEVGFIPSPVKLESTRQLQEQRMRQNRLSSSK------- 188

  Fly   173 GAGGQAGAEPSRGSTPPTP------------------------GDESDSMGPGRHGKTPAAAANK 213
             :||.:..:.:.|:..|||                        .|..|..|.|  |...:...|.
Zfish   189 -SGGSSSLDVATGARRPTPPGTADLSSGLYDDALDSDVEEAETADTRDHKGVG--GSVTSPQGNL 250

  Fly   214 EKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMAD 278
             .|.|||||.|...||||||||||::|||||||||||||||||||||||||:|||||.||||.||
Zfish   251 -PRLPFFKKMEHVPPYDVVPSMRPIILVGPSLKGYEVTDMMQKALFDFLKHKFEGRISITRVTAD 314

  Fly   279 ISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTS 343
            |||||||::|||||..|:||||:||. |.:||.||||||||||:||||.||.|||||||||||||
Zfish   315 ISLAKRSVLNNPSKHTIIERSSTRSS-LAEVQSEIERIFELARTLQLVALDADTINHPSQLAKTS 378

  Fly   344 LAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHI 408
            |||.|||:||:|.||||||||||||||||:|:||||||:|||||||::||:|||||||||||||:
Zfish   379 LAPIIVYIKIASPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPELFDIILDENQLEDACEHL 443

  Fly   409 AEYLETYWKATHPDIRAVP-PIARPLPQEASPSADPARLGPTPPVDGEEFV-DEQDPRMGMSGG- 470
            |||||.|||||||.....| |:.......|:.:|.|.   |...:.|...| .||...|...||
Zfish   444 AEYLEAYWKATHPPSSNPPNPLLNRTMATAALAASPE---PVSNLQGPFLVHGEQKREMPERGGL 505

  Fly   471 -----DREGSRERDRDSRERERERER---ERDYWDREFNRDRSS---KDRERDLEWERERAREWE 524
                 |..| ::..|.||.:.:...|   .:|.:|.|....|.|   .|.|.|...|.:..|.:.
Zfish   506 QDYQSDLSG-KQPLRSSRSQLQTGSRGLSRQDTFDSETQGSRDSAYTDDMETDPYEEPDPCRSYR 569

  Fly   525 RERERDWDREFDW-DQGGTSYQHSRRQ--PTSVRHQERGGG-------VGAGGGGGGVGGGYERD 579
            ........|:..| |:|....|.:...  |.:.:|| ||.|       ..|..||...|    |:
Zfish   570 LNPAHHAPRQASWEDEGAEPDQENLNMVPPPANQHQ-RGRGKLRERYCQDAEAGGATTG----RN 629

  Fly   580 RERERYER 587
            ..:|.:.|
Zfish   630 HNQEEWSR 637

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	24/40 (60%)
		SH3_CACNB	85..146	CDD:212797	45/60 (75%)
		Guanylate_kin	234..415	CDD:395500	150/180 (83%)
cacnb1	XP_005163865.2	VGCC_beta4Aa_N	61..102	CDD:463445	24/40 (60%)
		SH3_CACNB1	102..169	CDD:212974	50/66 (76%)
		Guanylate_kin	270..450	CDD:395500	150/180 (83%)