Protein Alignment Ca-beta and Cacnb4

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: NP_001032176.1
• Gene: Cacnb4 / 12298
• MGIID: 103301
• Length: 519
• Species: Mus musculus
• Alignment Length: 567
• Identity: 294/567 - (51%)
• Similarity: 369/567 - (65%)
• Gaps: 76/567 - (13%)

  Fly     5 ASSSDAPSVQ---GGQHRESRFGLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRR 65
            |....:||.|   |...|.||......|..| .:.:..||||||..|:|| ||:||:|::|::|:
Mouse    11 ADGPHSPSSQVARGTTTRRSRLKRSDGSTTS-TSFILRQGSADSYTSRPSDSDVSLEEDREAIRQ 74

  Fly    66 EKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGR 130
            |:|:||..||::|:||||||||:|||:|.||:|:|.||...|:||:.::||||||||:|:|||||
Mouse    75 EREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGR 139

  Fly   131 LVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTKGSSSGNLGAGGQAGAEPSRGSTPPTPGDES 195
            ||||||::||||||.:|:|||:|.:.:..|.:|  |.||||                      .|
Mouse   140 LVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHG--GKSSGN----------------------SS 180

  Fly   196 DSMG---PGRHGKTPAAAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA 257
            .|:|   .|....||...| |:|:    |..|...||||||||||||||||||||||||||||||
Mouse   181 SSLGEMVSGTFRATPTTTA-KQKQ----KVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA 240

  Fly   258 LFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARS 322
            |||||||||:|||.||||.|||||||||::||||||||:|||::||. |.:||.|||||||||||
Mouse   241 LFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSS-LAEVQSEIERIFELARS 304

  Fly   323 LQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQC 387
            |||||||.||||||:||.||||||.||::|:||.||||||||||||||:|:|:||:|||:|||||
Mouse   305 LQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQC 369

  Fly   388 PPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVPPIARPLPQEASPSADPARLGPTPPV 452
            ||:|||||||||||||||||:.||||.||:|||..  :..|:...|.:....:|    |.|.|
Mouse   370 PPEMFDVILDENQLEDACEHLGEYLEAYWRATHTS--SSTPMTPLLGRNVGSTA----LSPYP-- 426

  Fly   453 DGEEFVDEQDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKDRERDLEWER 517
                        ..:||...:..|..:..:.....|| |.....|..::.:|:.|.|.| |....
Mouse   427 ------------TAISGLQSQRMRHSNHSTENSPIER-RSLMTSDENYHNERARKSRNR-LSSSS 477

  Fly   518 ERAREWERERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERG--GG 562
            :.:|:.....|.|:.         .|||.:.:.     |:.||  ||
Mouse   478 QHSRDHYPLVEEDYP---------DSYQDTYKP-----HRNRGSPGG 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	22/40 (55%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:395500	151/180 (84%)
Cacnb4	NP_001032176.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..70		24/59 (41%)
		VGCC_beta4Aa_N	49..90	CDD:463445	22/40 (55%)
		SH3_CACNB4	90..157	CDD:212976	46/66 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..185		9/43 (21%)
		Guanylate_kin	217..397	CDD:395500	151/180 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..519		25/117 (21%)