DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-beta and Cacnb4

DIOPT Version :9

Sequence 1:	NP_001260375.1	Gene:	Ca-beta / 34557	FlyBaseID:	FBgn0259822	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	NP_001032176.1	Gene:	Cacnb4 / 12298	MGIID:	103301	Length:	519	Species:	Mus musculus

Alignment Length:	567	Identity:	294/567 - (51%)
Similarity:	369/567 - (65%)	Gaps:	76/567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ASSSDAPSVQ---GGQHRESRFGLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRR 65
            |....:||.|   |...|.||......|..| .:.:..||||||..|:|| ||:||:|::|::|:
Mouse    11 ADGPHSPSSQVARGTTTRRSRLKRSDGSTTS-TSFILRQGSADSYTSRPSDSDVSLEEDREAIRQ 74

  Fly    66 EKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGR 130
            |:|:||..||::|:||||||||:|||:|.||:|:|.||...|:||:.::||||||||:|:|||||
Mouse    75 EREQQAAIQLERAKSKPVAFAVKTNVSYCGALDEDVPVPSTAISFDAKDFLHIKEKYNNDWWIGR 139

  Fly   131 LVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTKGSSSGNLGAGGQAGAEPSRGSTPPTPGDES 195
            ||||||::||||||.:|:|||:|.:.:..|.:|  |.||||                      .|
Mouse   140 LVKEGCEIGFIPSPLRLENIRIQQEQKRGRFHG--GKSSGN----------------------SS 180

  Fly   196 DSMG---PGRHGKTPAAAANKEKRKPFFKKQETASPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA 257
            .|:|   .|....||...| |:|:    |..|...||||||||||||||||||||||||||||||
Mouse   181 SSLGEMVSGTFRATPTTTA-KQKQ----KVTEHIPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKA 240

  Fly   258 LFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCLGKVQEEIERIFELARS 322
            |||||||||:|||.||||.|||||||||::||||||||:|||::||. |.:||.|||||||||||
Mouse   241 LFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKRAIIERSNTRSS-LAEVQSEIERIFELARS 304

  Fly   323 LQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQAKNLSVQMVAAEKLAQC 387
            |||||||.||||||:||.||||||.||::|:||.||||||||||||||:|:|:||:|||:|||||
Mouse   305 LQLVVLDADTINHPAQLIKTSLAPIIVHVKVSSPKVLQRLIKSRGKSQSKHLNVQLVAADKLAQC 369

  Fly   388 PPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVPPIARPLPQEASPSADPARLGPTPPV 452
            ||:|||||||||||||||||:.||||.||:|||..  :..|:...|.:....:|    |.|.|
Mouse   370 PPEMFDVILDENQLEDACEHLGEYLEAYWRATHTS--SSTPMTPLLGRNVGSTA----LSPYP-- 426

  Fly   453 DGEEFVDEQDPRMGMSGGDREGSRERDRDSRERERERERERDYWDREFNRDRSSKDRERDLEWER 517
                        ..:||...:..|..:..:.....|| |.....|..::.:|:.|.|.| |....
Mouse   427 ------------TAISGLQSQRMRHSNHSTENSPIER-RSLMTSDENYHNERARKSRNR-LSSSS 477

  Fly   518 ERAREWERERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERG--GG 562
            :.:|:.....|.|:.         .|||.:.:.     |:.||  ||
Mouse   478 QHSRDHYPLVEEDYP---------DSYQDTYKP-----HRNRGSPGG 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	22/40 (55%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:279019	151/180 (84%)
		NK	244..416	CDD:302627	141/171 (82%)
Cacnb4	NP_001032176.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70		24/59 (41%)
		VGCC_beta4Aa_N	49..90	CDD:314861	22/40 (55%)
		SH3_CACNB4	90..157	CDD:212976	46/66 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..185		9/43 (21%)
		Guanylate_kin	217..397	CDD:331880	151/180 (84%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..519		25/117 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20188
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1221
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm42550
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11824
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.060