Protein Alignment: Ca-beta and Cacnb1

• Sequence 1: NP_001260375.1
• Gene: Ca-beta
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_006532154.1
• Gene: Cacnb1
• MGIID: 102522
• Length: 654
• Species: Mus musculus
• Alignment Length: 639
• Identity: 319/640 (50%)
• Similarity: 398/640 (62%)
• Gaps: 96/640 (15%)

  Fly    11 PSVQ----GGQH--RESRF--GLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRRE 66
            |.||    ||::  |:.||  ..|..|..:..|....||||:|..|:|| ||:||:|::|:||:|
Mouse    32 PRVQVPAAGGKYSKRKGRFKRSDGSTSSDTTSNSFVRQGSAESYTSRPSDSDVSLEEDREALRKE 96

  Fly    67 KERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRL 131
            .|||||:||:||::|||||||||||.|:.:..|:.||||.|::||.::||||||||:|:||||||
Mouse    97 AERQALAQLEKAKTKPVAFAVRTNVGYNPSPGDEVPVQGVAITFEPKDFLHIKEKYNNDWWIGRL 161

  Fly   132 VKEGCDVGFIPSPAKLDNIR-MQNQT-RPSRLYGTK-----GSSSGNLGAGGQAGAEPSRGSTPP 189
            |||||:|||||||.|||::| :|.|| |.:||..:|     .||.|::..|       :|..|||
Mouse   162 VKEGCEVGFIPSPVKLDSLRLLQEQTLRQNRLSSSKSGDNSSSSLGDVVTG-------TRRPTPP 219

  Fly   190 TPGDESDS----MGP----------GRHG---KTPAAAANKE----KRKPFFKKQETASPYDVVP 233
            ..|:|..:    :.|          |.||   ||..::....    ||.|||||.|...||||||
Mouse   220 ASGNEMTNFAFELDPLELEEEEAELGEHGGSAKTSVSSVTTPPPHGKRIPFFKKTEHVPPYDVVP 284

  Fly   234 SMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMER 298
            ||||::|||||||||||||||||||||||||||:|||.||||.|||||||||::|||||..|:||
Mouse   285 SMRPIILVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKHIIIER 349

  Fly   299 SSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLI 363
            |::||. |.:||.||||||||||:||||.||.||||||:||:||||||.|||:||:|.|||||||
Mouse   350 SNTRSS-LAEVQSEIERIFELARTLQLVALDADTINHPAQLSKTSLAPIIVYIKITSPKVLQRLI 413

  Fly   364 KSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVP- 427
            |||||||:|:|:||:.|:||||||||:|||:|||||||||||||:|||||.|||||||.....|
Mouse   414 KSRGKSQSKHLNVQIAASEKLAQCPPEMFDIILDENQLEDACEHLAEYLEAYWKATHPPSSTPPN 478

  Fly   428 PIARPLPQEASPSADPARL----GP-----TPPVD---GEE-FVDEQDPRMGMSGGDREGSRERD 479
            |:.......|:.:|.||.:    ||     ..|:|   ||. .|.|....:|...|....:....
Mouse   479 PLLNRTMATAALAASPAPVSNLQGPYLASGDQPLDRATGEHASVHEYPGELGQPPGLYPSNHPPG 543

  Fly   480 RDSRERERERERERDYWDREFNRDRSSKDRER-----DLEWERER--------------AREWER 525
            |....|...|:   |.:|.:....|:|...|.     |:|.:...              ||:...
Mouse   544 RAGTLRALSRQ---DTFDADTPGSRNSAYTEPGDSCVDMETDPSEGPGPGDPAGGGTPPARQGSW 605

  Fly   526 ERERDWDREFDWDQGGTSYQHSRRQPTSVRHQERGGGVGAG-------GGGGGV 572
            |.|.|::.|..        .:..|.....|:...|||...|       |.|.||
Mouse   606 EDEEDYEEEMT--------DNRNRGRNKARYCAEGGGPVLGRNKNELEGWGQGV 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	25/41 (61%)
		SH3_CACNB	85..146	CDD:212797	43/61 (70%)
		Guanylate_kin	234..415	CDD:279019	145/181 (80%)
		NK	244..416	CDD:302627	138/172 (80%)
Cacnb1	XP_006532154.1	VGCC_beta4Aa_N	70..111	CDD:288872	25/41 (61%)
		SH3_CACNB1	111..178	CDD:212974	49/67 (73%)
		Guanylate_kin	285..465	CDD:279019	145/181 (80%)
		GuKc	295..466	CDD:214504	138/172 (80%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C52537989
eggNOG	1	0.900				E1_KOG3812
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	511	1.000	Inparanoid score	I1297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000450
OrthoInspector	1	1.000				T615441
orthoMCL	1	0.900				OOG5_128949
Panther	1	1.100			LDO	PTHR11824
Phylome	1	0.910		0.778	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3437
TreeFam	1	0.960
	12	11.790