Protein Alignment Ca-beta and Cacnb2

DIOPT Version :9

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0259822
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_038951223.1
• Gene: Cacnb2 / 116600
• RGDID: 67385
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 650
• Identity: 325/650 - (50%)
• Similarity: 409/650 - (62%)
• Gaps: 81/650 - (12%)

  Fly     5 ASSSDAPSVQGGQHRESRF--GLGYPSYQSGYNKLFTQGSADSNYSQPS-SDLSLDEEKESLRRE 66
            |.:..|.|...|..|::||  ..|..|..:..|....||||||..|:|| ||:||:|::|::|||
  Rat    30 AGALGAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRRE 94

  Fly    67 KERQALSQLDKARSKPVAFAVRTNVAYDGAIDDDSPVQGGAVSFEIREFLHIKEKYDNNWWIGRL 131
            .||||.:||:||::|||||||||||.|..|.:||.||.|.|:|||.::|||:|||::|:||||||
  Rat    95 AERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRL 159

  Fly   132 VKEGCDVGFIPSPAKLDNIRMQNQTR--PSRLYGTK--GSSSGNLGAGGQAGAEP-SRGSTPPTP 191
            |||||::||||||.||:|:|:|::.|  ..:.|.:|  |:||.:||     ...| ||.||||:.
  Rat   160 VKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLG-----DIVPSSRKSTPPSS 219

  Fly   192 GDESDSMG--------PGRHGKTPAAAAN-------KEKRKPFFKKQETASPYDVVPSMRPVVLV 241
            ..:.|:.|        |..| ::|..:||       ||||.|||||.|...||||||||||||||
  Rat   220 AIDIDATGLDAEENDIPANH-RSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLV 283

  Fly   242 GPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKRAIMERSSSRSDCL 306
            |||||||||||||||||||||||||||||.||||.|||||||||::|||||.||:|||::||. |
  Rat   284 GPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSS-L 347

  Fly   307 GKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKVLQRLIKSRGKSQA 371
            .:||.||||||||||:|||||||.||||||:||:||||||.|||:||||.|||||||||||||||
  Rat   348 AEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQA 412

  Fly   372 KNLSVQMVAAEKLAQCPP-DMFDVILDENQLEDACEHIAEYLETYWKATHPDIRAVPP--IARPL 433
            |:|:||||||:||||||| :.||||||||||||||||:|:|||.|||||||....:|.  ::|.|
  Rat   413 KHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYLEAYWKATHPPSSNLPNPLLSRTL 477

  Fly   434 PQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRERERERERE------ 492
            .....| ..|.....:....|::..|...|| ..|..:.|...|..:.|:.|......:
  Rat   478 ATSTLP-LSPTLASNSQGSQGDQRTDRSAPR-SASQAEEEPCLEPVKKSQHRSSSATHQNHRSGT 540

  Fly   493 ------RDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQP 551
                  ::.:|.|....|.|...|...::..|....:...||.:...|.....|     |..|:|
  Rat   541 GRGLSRQETFDSETQESRDSAYVEPKEDYSHEHVDRYVPHREHNHREESHSSNG-----HRHREP 600

  Fly   552 TSVRHQERGGGVGAGGGGGGVGGGYERD-------RERERYERRERDLMHYDLNSDELLDERNFE 609
               ||:.|..|               ||       ::|.|::.::|    |.....|::.:|..|
  Rat   601 ---RHRTRDMG---------------RDQDHNECSKQRSRHKSKDR----YCDKEGEVISKRRSE 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	25/40 (63%)
		SH3_CACNB	85..146	CDD:212797	42/60 (70%)
		Guanylate_kin	234..415	CDD:279019	153/181 (85%)
		NK	244..416	CDD:302627	143/172 (83%)
Cacnb2	XP_038951223.1	VGCC_beta4Aa_N	68..109	CDD:403316	25/40 (63%)
		SH3_CACNB2	108..176	CDD:212973	47/67 (70%)
		Guanylate_kin	276..457	CDD:395500	153/181 (85%)
		SF-CC1	586..>643	CDD:273721	17/83 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340132
Domainoid	1	1.000	296	1.000	Domainoid score	I1418
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	528	1.000	Inparanoid score	I1187
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm44615
orthoMCL	1	0.900	-	-		OOG6_105007
Panther	1	1.100	-	-	LDO	PTHR11824
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890