DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-beta and cacnb4

DIOPT Version :9

Sequence 1:	NP_001260375.1	Gene:	Ca-beta / 34557	FlyBaseID:	FBgn0259822	Length:	844	Species:	Drosophila melanogaster
Sequence 2:	XP_012825641.1	Gene:	cacnb4 / 100216182	XenbaseID:	XB-GENE-1012455	Length:	520	Species:	Xenopus tropicalis

Alignment Length:	548	Identity:	285/548 - (52%)
Similarity:	358/548 - (65%)	Gaps:	83/548 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 LFTQGSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDD 100
            :..||||||..|:|| ||:||:|::|::|:|:|:||..||::|::|||||||||||:|.||:|:|
Frog    46 ILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAVQLERAKTKPVAFAVRTNVSYCGALDED 110

  Fly   101 SPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTK 165
            .||.|.|:||:.::||||||||:|:|||||||||||::||||||.:||.||:|.:.:..|.:|.|
Frog   111 VPVPGTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPQRLDYIRVQQEQKRGRTHGGK 175

  Fly   166 --GSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASP 228
              |:||.:||       |...|:...||               |:||..|:      |..|...|
Frog   176 SSGNSSSSLG-------EMVSGTFRATP---------------PSAAKQKQ------KVTELVPP 212

  Fly   229 YDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKR 293
            ||||||||||||||||||||||||||||||||||||||:|||.||||.|||||||||::|||||:
Frog   213 YDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKK 277

  Fly   294 AIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKV 358
            .|:|||::||. |.:||.|||||||||||||||:||.||||||:||.||||||.||::|:||.||
Frog   278 MIIERSNTRSS-LAEVQSEIERIFELARSLQLVILDADTINHPAQLIKTSLAPIIVHVKVSSPKV 341

  Fly   359 LQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDI 423
            ||||||||||||:|:|:||:|||:|||||||:|||||||||||||||||:|||||.||:|||...
Frog   342 LQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLAEYLEAYWRATHTTS 406

  Fly   424 RA--VPPIARPLPQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRERE 486
            ..  .|.:.|.|...|..|.      ||                .:||...:..|..:..:....
Frog   407 TTPMTPLLGRNLGSTALTSY------PT----------------AISGLQSQRMRHSNHSTENSP 449

  Fly   487 RERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQP 551
            .|| |.....|..::.:|:.|.|.|     ...:.:..|:.....:.||     ..|||.:.:.
Frog   450 IER-RSLMTSDENYHNERARKSRNR-----LSSSSQHSRDHYPLVEEEF-----SDSYQDTYKP- 502

  Fly   552 TSVRHQERGGGVGAGGGGGGVGGGYERD 579
                |:.||.           .|||..|
Frog   503 ----HRNRGS-----------PGGYSHD 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:288872	22/40 (55%)
		SH3_CACNB	85..146	CDD:212797	44/60 (73%)
		Guanylate_kin	234..415	CDD:279019	149/180 (83%)
		NK	244..416	CDD:302627	139/171 (81%)
cacnb4	XP_012825641.1	VGCC_beta4Aa_N	50..91	CDD:371868	22/40 (55%)
		SH3_CACNB4	91..158	CDD:212976	48/66 (73%)
		Guanylate_kin	218..398	CDD:366206	149/180 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1406
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H20188
Inparanoid	1	1.050	535	1.000	Inparanoid score	I1175
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000994
OrthoInspector	1	1.000	-	-		otm47649
Panther	1	1.100	-	-	O	PTHR11824
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1029
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.150