Protein Alignment Ca-beta and cacnb4

DIOPT Version :10

• Sequence 1: NP_001260375.1
• Gene: Ca-beta / 34557
• FlyBaseID: FBgn0287724
• Length: 844
• Species: Drosophila melanogaster
• Sequence 2: XP_012825641.1
• Gene: cacnb4 / 100216182
• XenbaseID: XB-GENE-1012455
• Length: 520
• Species: Xenopus tropicalis
• Alignment Length: 548
• Identity: 285/548 - (52%)
• Similarity: 358/548 - (65%)
• Gaps: 83/548 - (15%)

  Fly    37 LFTQGSADSNYSQPS-SDLSLDEEKESLRREKERQALSQLDKARSKPVAFAVRTNVAYDGAIDDD 100
            :..||||||..|:|| ||:||:|::|::|:|:|:||..||::|::|||||||||||:|.||:|:|
 Frog    46 ILRQGSADSYTSRPSDSDVSLEEDREAIRQEREQQAAVQLERAKTKPVAFAVRTNVSYCGALDED 110

  Fly   101 SPVQGGAVSFEIREFLHIKEKYDNNWWIGRLVKEGCDVGFIPSPAKLDNIRMQNQTRPSRLYGTK 165
            .||.|.|:||:.::||||||||:|:|||||||||||::||||||.:||.||:|.:.:..|.:|.|
 Frog   111 VPVPGTAISFDAKDFLHIKEKYNNDWWIGRLVKEGCEIGFIPSPQRLDYIRVQQEQKRGRTHGGK 175

  Fly   166 --GSSSGNLGAGGQAGAEPSRGSTPPTPGDESDSMGPGRHGKTPAAAANKEKRKPFFKKQETASP 228
              |:||.:||       |...|:...||               |:||..|:      |..|...|
 Frog   176 SSGNSSSSLG-------EMVSGTFRATP---------------PSAAKQKQ------KVTELVPP 212

  Fly   229 YDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRIIITRVMADISLAKRSIMNNPSKR 293
            ||||||||||||||||||||||||||||||||||||||:|||.||||.|||||||||::|||||:
 Frog   213 YDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADISLAKRSVLNNPSKK 277

  Fly   294 AIMERSSSRSDCLGKVQEEIERIFELARSLQLVVLDCDTINHPSQLAKTSLAPTIVYLKISSSKV 358
            .|:|||::||. |.:||.|||||||||||||||:||.||||||:||.||||||.||::|:||.||
 Frog   278 MIIERSNTRSS-LAEVQSEIERIFELARSLQLVILDADTINHPAQLIKTSLAPIIVHVKVSSPKV 341

  Fly   359 LQRLIKSRGKSQAKNLSVQMVAAEKLAQCPPDMFDVILDENQLEDACEHIAEYLETYWKATHPDI 423
            ||||||||||||:|:|:||:|||:|||||||:|||||||||||||||||:|||||.||:|||...
 Frog   342 LQRLIKSRGKSQSKHLNVQLVAADKLAQCPPEMFDVILDENQLEDACEHLAEYLEAYWRATHTTS 406

  Fly   424 RA--VPPIARPLPQEASPSADPARLGPTPPVDGEEFVDEQDPRMGMSGGDREGSRERDRDSRERE 486
            ..  .|.:.|.|...|..|.      ||                .:||...:..|..:..:....
 Frog   407 TTPMTPLLGRNLGSTALTSY------PT----------------AISGLQSQRMRHSNHSTENSP 449

  Fly   487 RERERERDYWDREFNRDRSSKDRERDLEWERERAREWERERERDWDREFDWDQGGTSYQHSRRQP 551
            .|| |.....|..::.:|:.|.|.|     ...:.:..|:.....:.||     ..|||.:.:.
 Frog   450 IER-RSLMTSDENYHNERARKSRNR-----LSSSSQHSRDHYPLVEEEF-----SDSYQDTYKP- 502

  Fly   552 TSVRHQERGGGVGAGGGGGGVGGGYERD 579
                |:.||.           .|||..|
 Frog   503 ----HRNRGS-----------PGGYSHD 515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-beta	NP_001260375.1	VGCC_beta4Aa_N	41..81	CDD:463445	22/40 (55%)
		SH3_CACNB	85..146	CDD:212797	44/60 (73%)
		Guanylate_kin	234..415	CDD:395500	149/180 (83%)
cacnb4	XP_012825641.1	VGCC_beta4Aa_N	50..91	CDD:463445	22/40 (55%)
		SH3_CACNB4	91..158	CDD:212976	48/66 (73%)
		Guanylate_kin	218..398	CDD:395500	149/180 (83%)