DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup160 and NUP120

DIOPT Version :9

Sequence 1:	NP_001285832.1	Gene:	Nup160 / 34549	FlyBaseID:	FBgn0262647	Length:	1411	Species:	Drosophila melanogaster
Sequence 2:	NP_012866.1	Gene:	NUP120 / 853808	SGDID:	S000001540	Length:	1037	Species:	Saccharomyces cerevisiae

Alignment Length:	1123	Identity:	222/1123 - (19%)
Similarity:	404/1123 - (35%)	Gaps:	311/1123 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 YVTDGFGTMPNAAVSYLTQDSQSAYFAVAYQSKLL-LHVMKCSTG--HTIT-HEIKEPKLMPWFL 223
            |:...|.:.......|...|        ||..|.: :|:...|..  :|:| .|:::..|:...|
Yeast    67 YICYHFSSRSTLLTFYPLSD--------AYHGKTINIHLPNASMNQRYTLTIQEVEQQLLVNVIL 123

  Fly   224 SNLKGALTGRSETLEAATSMAFSE---IGGEIFIL-------------VLYRNNELRLWSVDN-- 270
            .:      |...||:...|..||.   :.||.|.|             :.|.:.:..:..:::
Yeast   124 KD------GSFLTLQLPLSFLFSSANTLNGEWFHLQNPYDFTVRVPHFLFYVSPQFSVVFLEDGG 182

  Fly   271 ---LQTVASINCSTELGQDSAAQGPQNSQLRKISDQNFCLFLSHNSRAEFICVSIMPDADDASVI 332
               |:.|..::....|..|       ||.|:.::     .|.|.:|::::..|.......:..:|
Yeast   183 LLGLKKVDGVHYEPLLFND-------NSYLKSLT-----RFFSRSSKSDYDSVISCKLFHERYLI 235

  Fly   333 NLVQNMVPAPQTDLVDF------------DATSSHIWALWSNAEGDFHVSAAYFASNNAIKWVSA 385
            .|.|| ......||..|            |:..||...:  .|.|::  .:.|   ||.:..:
Yeast   236 VLTQN-CHLKIWDLTSFTLIQDYDMVSQSDSDPSHFRKV--EAVGEY--LSLY---NNTLVTL-- 290

  Fly   386 ALEPPPDRYCLTMEQGVDPRET-------YCSYIFHPGRFDRNVIAKALY------MFRRVNLQF 437
                      |.:|.|:....|       ..:|.|. .....|:.|.|::      :.|.:.|..
Yeast   291 ----------LPLENGLFQMGTLLVDSSGILTYTFQ-NNIPTNLSASAIWSIVDLVLTRPLELNV 344

  Fly   438 DVKQLSMSVL-------KEQVCQAVEDE-------IQNELKDFVVTDEEY-LEISTRLWD---RF 484
            :...|::.||       |.|:.. |.||       |::..|..|....|: |:|.|:..|   .|
Yeast   345 EASYLNLIVLWKSGTASKLQILN-VNDESFKNYEWIESVNKSLVDLQSEHDLDIVTKTGDVERGF 408

  Fly   485 YSCCEQYHIKLSEPTGLAVLGGMDAVCLVRRQSFALLRPCEVLEHLLLIGEHNDEVATYVAPLFR 549
            .:...:|..::.|                        |..::|....:|..||:: ..|:|.|..
Yeast   409 CNLKSRYGTQIFE------------------------RAQQILSENKIIMAHNED-EEYLANLET 448

  Fly   550 NDPEMAKGFVELMNVVTLLDKLISEDIKIELDKQLYQRESPVEVI----------SKLVARISMI 604
            ...::...|.|..::....|::|..:.....:..||:..:.||..          |:|...:..:
Yeast   449 ILRDVKTAFNEASSITLYGDEIILVNCFQPYNHSLYKLNTTVENWFYNMHSETDGSELFKYLRTL 513

  Fly   605 DDNGPILPSNCVRQIQQKLQNIPNLEPALEMLLDVLCMIDPDEPPHDYSLST--RFLQSSGALMG 667
            :.....|.::.:|.|.:|             .||::....||      |::|  :|.......:.
Yeast   514 NGFASTLSNDVLRSISKK-------------FLDIITGELPD------SMTTVEKFTDIFKNCLE 559

  Fly   668 SEYGLSILSETVKQMAMIRFSVCRNLLVLQYMAYG---QNEMESE---NVLTNLNYLNSYYTLVW 726
            :::.::.|.....::......|..|.|:...|..|   :.:..|.   :..|::..|.|.:.|:.
Yeast   560 NQFEITNLKILFDELNSFDIPVVLNDLINNQMKPGIFWKKDFISAIKFDGFTSIISLESLHQLLS 624

  Fly   727 IAETPISSSTPAGFEASIQRLSRAQLFSGYNRPYSSHLK-----HNGNDQTTLLRLFLESKGLFS 786
            |           .:..::|.|....||......:..|:.     |  ..|..||.|:.:.|.|.:
Yeast   625 I-----------HYRITLQVLLTFVLFDLDTEIFGQHISTLLDLH--YKQFLLLNLYRQDKCLLA 676

  Fly   787 ALTMLLKHDSLSLDSEQLNLRQSLL---QLVGYINKMLWPGSPIY------------VFPEWLFG 836
              .:|||      ||.:.:......   ||:.||:.:   .|.:|            .|..::..
Yeast   677 --EVLLK------DSSEFSFGVKFFNYGQLIAYIDSL---NSNVYNASITENSFFMTFFRSYIIE 730

  Fly   837 TCHHIIVQDYVRILSNWCSV---QKHARRFMLAVSLLDCGEAHKAVHLF--HEAESGIVEDDFLF 896
            ...|..::.::..:.  |..   ....:.||.|::|..||...::..:|  |:....|.:....|
Yeast   731 NTSHKNIRFFLENVE--CPFYLRHNEVQEFMFAMTLFSCGNFDQSYEIFQLHDYPEAINDKLPTF 793

  Fly   897 EHVLKNTPLYGKLQNSVSRGDTISPEDTKLAIVHYYLKVIQLFE----QHSALDYIIQLADMAIR 957
            ...||:...:|   :|:.: |.:...........:|.::..||:    |..||..|.:.|:.:::
Yeast   794 LEDLKSENYHG---DSIWK-DLLCTFTVPYRHSAFYYQLSLLFDRNNSQEFALKCISKSAEYSLK 854

  Fly   958 VLQPDDPQ----------------LPMFQSIVFNNHLQLGHYVEAYTALVNNADISRRKDCLRQL 1006
            .:|.::.|                ..||:.::  :.|:|||                  :||...
Yeast   855 EIQIEELQDFKEKQHIHYLNLLIHFRMFEEVL--DVLRLGH------------------ECLSDT 899

  Fly  1007 VITLFQNKCLPLLMQFSYIGLQDEFESIV----------ESRARSMSI-------DQN------E 1048
            |.|.|    |.||:| ..|..:|.|.:::          |...|::.|       .||      |
Yeast   900 VRTNF----LQLLLQ-EDIYSRDFFSTLLRLCNAHSDNGELYLRTVDIKIVDSILSQNLRSGDWE 959

  Fly  1049 VYNFLYAFHTNKGNMRKASTVMYEQAMRFQVDSDAPNALEKRCSSLLICLNCLHLVDSRY-RWIA 1112
            .:..||.|.....:.|.|:.|:| |.:..|.|.|   .:.||...|:: :|.|...||.| :||
Yeast   960 CFKKLYCFRMLNKSERAAAEVLY-QYILMQADLD---VIRKRKCYLMV-INVLSSFDSAYDQWI- 1018

  Fly  1113 KPVLGDEQVITIDQDNDD 1130
               |...:|:|:....|:
Yeast  1019 ---LNGSKVVTLTDLRDE 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup160	NP_001285832.1	Nup160	28..530	CDD:288551	83/434 (19%)
NUP120	NP_012866.1	Nup160	91..>372	CDD:403040	63/320 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR21286
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100