DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup160 and Nup160

DIOPT Version :9

Sequence 1:	NP_001285832.1	Gene:	Nup160 / 34549	FlyBaseID:	FBgn0262647	Length:	1411	Species:	Drosophila melanogaster
Sequence 2:	XP_038960817.1	Gene:	Nup160 / 311182	RGDID:	1311052	Length:	1402	Species:	Rattus norvegicus

Alignment Length:	1447	Identity:	415/1447 - (28%)
Similarity:	681/1447 - (47%)	Gaps:	167/1447 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LKTFETSGGYCYKNTKNV--QTRNRFIYWRTYQDVLELSEVSLDISLQRNHLRLRFTDSAVL--N 101
            :|..|::||:.|..:..:  .||||||:|:|..|.|||.|.|||::|..|.:||:|.:.::|  .
  Rat    43 VKYSESAGGFYYVESGKLFSITRNRFIHWKTSGDTLELVEESLDLNLLNNAVRLKFQNYSLLPGG 107

  Fly   102 VSLTEQGTSVTLLVVTVSSVHRYVFPLKVAGQEGGAASPEDLLSQSIFYDVNDKIN--DPSTYYV 164
            |.::|....|.:|::|..:|||.:.|...........:...:  ||||.|:. |::  ||..|.:
  Rat   108 VHVSETQNHVIILILTNHTVHRLILPHPSRMYRSELVTESQM--QSIFTDIG-KVDFKDPCNYQL 169

  Fly   165 ---TDGFGTMPNAAVSYLTQDSQSAYFAVAYQSKLLLHVMKCS----TGHTITHEIKEPKLMPWF 222
               ..|.......:.::|:.|.: |.||:...|..:. |:|..    .|.....|:|:..:|...
  Rat   170 IPTVPGLSPSSTTSAAWLSSDGE-ALFALPSASGGIF-VLKLPPYDIPGIASVVELKQSSVMQRL 232

  Fly   223 LSN-LKGALTGRSETLEAATSMAFSEIGGEIFILVLYRNNELRLWSVDNLQTVASINCSTELGQD 286
            |:. :..|:.|.....:.|.|:|...:..:.||..|.::::||:||..:...:        :..|
  Rat   233 LTGWMPTAIRGDHGPSDRALSLAVHCVEHDAFIFALCQDHKLRMWSYKDQMCL--------MVAD 289

  Fly   287 SAAQGPQNSQLRKISDQNFCLFLSHN--------------SRAEFICVSIMPDADDASVINLVQN 337
            .....|.|..||..:.....|.|:::              .|.:|....::........::.:.:
  Rat   290 MLEYVPVNKDLRLTAGTGHKLRLAYSPSMGLYLGIYMHAPKRGQFCIFQLVSTESSRYSLDHISS 354

  Fly   338 MVPAPQTDLVDFDATSSHIWALWSNAEGDFHVSAAYFASNNAIKWVSAALEPPPDRYCLTMEQGV 402
            :..:.:| ||||..||:.|||||.:||....|....|..|.|.:|....::..|:.. :.:....
  Rat   355 LFTSQET-LVDFALTSTDIWALWHDAENQTIVKYINFEHNVAGQWNPVFMQSLPEEE-IVIRDDQ 417

  Fly   403 DPRETYCSYIFHPGRFDRNVIAKALYMFRR---VNLQFDVKQLSMSVLKEQVCQAVEDEIQNELK 464
            ||||.|...:|.||:|....:.|||.:|.|   .||     .||.|.||:::..|||:|:|..:.
  Rat   418 DPREMYLRSLFTPGQFINAALCKALQIFCRGTERNL-----DLSWSELKKEITLAVENELQGSVT 477

  Fly   465 DFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTGLAVLGGMDAVCLVRRQSFALLRPCEVLEH 529
            ::..:.:|:..:....|.:||:||.||...||.|..|.:....:.|||:::...:.|.|..:::|
  Rat   478 EYEFSQDEFRTLQQEFWCKFYACCLQYQEALSHPLALHLNPLTNMVCLLKKGYLSFLVPSSLVDH 542

  Fly   530 L-LLIGEH---NDEVATYVAPLFRNDPEMAKGFVELMNVVTLLDKLISEDIKIELDKQLYQRESP 590
            | ||..||   .||..      ..:|.::|:..:.|:..:.::.:.::.|:.:.::...|..:||
  Rat   543 LYLLPDEHLLTEDETT------ISDDADVARDVLCLIKCLRMIGESVTMDMAVLMETSCYNLQSP 601

  Fly   591 VEVISKLVARISMIDDNGPILPSNCVRQIQQKLQNIPNLEPALEMLL---------DVLCMIDPD 646
            .:....::..:..||      ..|.:..|..|||.|.|...|:.:|:         ::....||.
  Rat   602 EKAAEHILEDLITID------VENVMEDICSKLQEIRNPVHAIGLLIREMDYETEVEMEKGFDPA 660

  Fly   647 EPPHDYSLSTRFLQSSGALMGSEYGLSILSETVKQMAMIRFSVCRNLLVLQ----------YMAY 701
            :|     |:.|...|.  |.||.....|:...|.::|..||.:||:||:||          .:..
  Rat   661 QP-----LNVRMNLSQ--LYGSSTAGYIVCRGVYKIASTRFLICRDLLILQQLLTRLGDAVILGA 718

  Fly   702 GQNEMESENVL-TNLNYLNSYYTLVWIAETPISSSTPAG-FEASIQRLSRAQLF-SG---YNRPY 760
            ||.....:::| .....|.|||.:.|.::. :::..|.. .|:::|.||..:|. ||   .|:..
  Rat   719 GQLFQAQQDLLHRTAPLLLSYYLIKWSSQC-LATDVPVDTLESNLQHLSVLELTDSGALMANKLV 782

  Fly   761 SSHLKHNGNDQTTLLRLFLESKGLFSALTMLLKHDSLSLDSEQLNLRQSLLQLVGYINKMLWPGS 825
            ||        ..|::.||.:.......::.|.......|....||..:.:..:.||:.::|||.:
  Rat   783 SS--------PQTIMELFFQEVARKHIISHLFSQPKAPLSQTGLNWPEMVTAVTGYLLQLLWPSN 839

  Fly   826 PIYVFPEWLFGTCHHIIVQDYVRILSNWCSVQKHARRFMLAVSLLDCGEAHKAVHLFHEAESGIV 890
            |..:|.|.|.|.|.::.:|||:::|..||.|...:.||||....|..||..||:..|.:|.|.:.
  Rat   840 PGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEVQKALECFCQAASEVG 904

  Fly   891 EDDFLFEHV------LKNTPLYGKLQNSVSRGDTISPEDTKLAIVHYYLKVIQLFEQHSALDYII 949
            :::||...:      :.:||   |||                    ||.||::|.:.....:.:|
  Rat   905 KEEFLDRLIRTEDGEIVSTP---KLQ--------------------YYDKVLRLLDVVGLPELVI 946

  Fly   950 QLADMAIRVLQPDDPQLPMFQSIVFNNHLQLGHYVEAYTALVNNADISRRKDCLRQLVITLFQNK 1014
            |||..||.....|.......::.:|.:||.|||..:||.||....|.||:.|||||||:.|.:..
  Rat   947 QLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLRQLVVVLCERS 1011

  Fly  1015 CLPLLMQFSYIGLQDEFESIVESRARSMSIDQNEVYNFLYAFHTNKGNMRKASTVMYEQAMRFQV 1079
            .|..|::|.|:.|.:|...|:|||||::.:..:..|..|||||..:.|.|||.|||:|..||...
  Rat  1012 QLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTVMFEYGMRLGR 1076

  Fly  1080 DSDAPNALEKRCSSLLICLNCLHLVDSRYRWIAKPVLG--DEQVITIDQDNDDGEPKCDEDKRGQ 1142
            :......|||:.:..|..:|||.|:...|.||.:|..|  .::.....:.|.|||  |......:
  Rat  1077 EVRTLGGLEKQGNCYLAAINCLRLIRPEYAWIVQPASGAVSDRPGASPKRNHDGE--CTAAPTNR 1139

  Fly  1143 EVVVLELADIRRELVHAEALRELSFYRKDTAAYERA---TPEELSYLLASSGLYTAALKLSRGHS 1204
            ::.:|||.|:.:|...|..  .|:..|.|.:|...|   :.:|:|.||..:||:..|:.|.:...
  Rat  1140 QIEILELEDLEKECSLARI--RLTLARHDPSAIAIAGSSSAKEMSTLLVQAGLFDTAISLCQTFK 1202

  Fly  1205 FSVLPIFESLTSACVA---ATEDKSSDAWNWLQNNDMADL--PHRSNAADMAW----TLLQKLVV 1260
            ..:.|:||.|...|:.   ..|....:||.||..|.::.:  ...|:|.|.||    |.|::..|
  Rat  1203 LPLTPVFEGLAFKCIKLQFGGEAAQGEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKV 1267

  Fly  1261 DNEAKDSTLIRKSVVQRLLGLNAFLPQWLINSYKLSHSRELLHLLVKHNRLLEAADLGCEIIAGM 1325
            .|     .|....|:.:||.....||.|||||||...:.|||.|.:.::.|.||.||..|.:..:
  Rat  1268 QN-----NLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAV 1327

  Fly  1326 LGAGSEYFEFKHAVNIANPQLCFPISTIDLLLHGLKINGKDDLDYEMAYFKLEEEVQRYIETIKR 1390
            ||.|.:||..:..::...|.:..|.|:||.||..|..|..:..:..::. |:.::::.|.:.:.:
  Rat  1328 LGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIILSQ-KILDKLEDYQQKVDK 1391

  Fly  1391 TTDDKMSMAVLQMRTDL 1407
            .|.|      |..|.||
  Rat  1392 ATRD------LLYRRDL 1402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup160	NP_001285832.1	Nup160	28..530	CDD:288551	143/519 (28%)
Nup160	XP_038960817.1	Nup160	28..543	CDD:403040	151/534 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334866
Domainoid	1	1.000	272	1.000	Domainoid score	I1740
eggNOG	1	0.900	-	-		E1_KOG4521
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32509
Inparanoid	1	1.050	419	1.000	Inparanoid score	I1745
OMA	1	1.010	-	-		QHG45584
OrthoDB	1	1.010	-	-		D284127at2759
OrthoFinder	1	1.000	-	-		FOG0005509
OrthoInspector	1	1.000	-	-		oto96710
orthoMCL	1	0.900	-	-		OOG6_104899
Panther	1	1.100	-	-	LDO	PTHR21286
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5111
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810