Protein Alignment: Nup160 and NUP160

• Sequence 1: NP_001285832.1
• Gene: Nup160
• FlyBaseID: FBgn0262647
• Length: 1411
• Species: Drosophila melanogaster
• Sequence 2: NP_056046.1
• Gene: NUP160
• HGNCID: 18017
• Length: 1436
• Species: Homo sapiens
• Alignment Length: 1455
• Identity: 420/1456 (29%)
• Similarity: 688/1456 (47%)
• Gaps: 186/1456 (13%)

  Fly    41 LKTFETSGGYCYKNTKNV--QTRNRFIYWRTYQDVLELSEVSLDISLQRNHLRLRFTDSAVL--N 101
            :|..|::||:.|..:..:  .||||||:|:|..|.|||.|.||||:|..|.:||:|.:.:||  .
Human    77 VKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLDINLLNNAIRLKFQNCSVLPGG 141

  Fly   102 VSLTEQGTSVTLLVVTVSSVHRYVFP---------LKVAGQEGGAASPEDLLSQSIFYDVNDKIN 157
            |.::|....|.:|::|..:|||.:.|         |.|..|           .||||.|:. |::
Human   142 VYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVDSQ-----------MQSIFTDIG-KVD 194

  Fly   158 --DPSTYYVTDGF-GTMPN--AAVSYLTQDSQSAYFAVAYQSKLLLHVMKCS----TGHTITHEI 213
              ||..|.:.... |..||  |:.::|:.|.: |.||:...|..:. |:|..    .|.....|:
Human   195 FTDPCNYQLIPAVPGISPNSTASTAWLSSDGE-ALFALPCASGGIF-VLKLPPYDIPGMVSVVEL 257

  Fly   214 KEPKLMPWFLSN-LKGALTGRSETLEAATSMAFSEIGGEIFILVLYRNNELRLWS---------V 268
            |:..:|...|:. :..|:.|.....:...|:|...:..:.||..|.::::||:||         .
Human   258 KQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIFALCQDHKLRMWSYKEQMCLMVA 322

  Fly   269 DNLQTVASINCSTELGQDSAAQGPQNSQLRKISDQNFCLFLSHN--------------SRAEFIC 319
            |.|:.|                 |....||..:.....|.|:::              .|.:|..
Human   323 DMLEYV-----------------PVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKRGQFCI 370

  Fly   320 VSIMPDADDASVINLVQNMVPAPQTDLVDFDATSSHIWALWSNAEGDFHVSAAYFASNNAIKWVS 384
            ..::....:...::.:.::..:.:| |:||..||:.|||||.:||....|....|..|.|.:|..
Human   371 FQLVSTESNRYSLDHISSLFTSQET-LIDFALTSTDIWALWHDAENQTVVKYINFEHNVAGQWNP 434

  Fly   385 AALEPPPDRYCLTMEQGVDPRETYCSYIFHPGRFDRNVIAKALYMFRR---VNLQFDVKQLSMSV 446
            ..::|.|:.. :.:....||||.|...:|.||:|....:.|||.:|.|   .||     .||.|.
Human   435 VFMQPLPEEE-IVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTERNL-----DLSWSE 493

  Fly   447 LKEQVCQAVEDEIQNELKDFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTGLAVLGGMDAVC 511
            ||::|..|||:|:|..:.::..:.||:..:....|.:||:||.||...||.|..|.:....:.||
Human   494 LKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLALHLNPHTNMVC 558

  Fly   512 LVRRQSFALLRPCEVLEHLLLIGEHN----DEVATYVAPLFRNDPEMAKGFVELMNVVTLLDKLI 572
            |:::...:.|.|..:::||.|:...|    ||..      ..:|.::|:..:.|:..:.|:::.:
Human   559 LLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETT------ISDDVDIARDVICLIKCLRLIEESV 617

  Fly   573 SEDIKIELDKQLYQRESPVEVISKLVARISMIDDNGPILPSNCVRQIQQKLQNIPNLEPALEML- 636
            :.|:.:.::...|..:||.:...:::..:..||      ..|.:..|..|||.|.|...|:.:|
Human   618 TVDMSVIMEMSCYNLQSPEKAAEQILEDMITID------VENVMEDICSKLQEIRNPIHAIGLLI 676

  Fly   637 --LDVLCMIDPDE---PPHDYSLSTRFLQSSGALMGSEYGLSILSETVKQMAMIRFSVCRNLLVL 696
              :|....::.::   |....::.....|    |.||.....|:...|.::|..||.:||:||:|
Human   677 REMDYETEVEMEKGFNPAQPLNIRMNLTQ----LYGSNTAGYIVCRGVHKIASTRFLICRDLLIL 737

  Fly   697 QYM----------AYGQNEMESENVL-TNLNYLNSYYTLVWIAETPISSSTPAG-FEASIQRLSR 749
            |.:          ..||.....:::| .....|.|||.:.|.:|. :::..|.. .|:::|.||.
Human   738 QQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGSEC-LATDVPLDTLESNLQHLSV 801

  Fly   750 AQLF-SG---YNRPYSSHLKHNGNDQTTLLRLFLESKGLFSALTMLLKHDSLSLDSEQLNLRQSL 810
            .:|. ||   .||..||        ..|::.||.:.......::.|.......|....||..:.:
Human   802 LELTDSGALMANRFVSS--------PQTIVELFFQEVARKHIISHLFSQPKAPLSQTGLNWPEMI 858

  Fly   811 LQLVGYINKMLWPGSPIYVFPEWLFGTCHHIIVQDYVRILSNWCSVQKHARRFMLAVSLLDCGEA 875
            ..:..|:.::|||.:|..:|.|.|.|.|.::.:|||:::|..||.|...:.||||....|..||.
Human   859 TAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEG 923

  Fly   876 HKAVHLFHEAESGIVEDDFLFEHVLKNTPLYGKLQNSVSRGDTIS-PEDTKLAIVHYYLKVIQLF 939
            .||:..|.:|.|.:.:::|| :.::::           ..|:.:| |.      :.||.||::|.
Human   924 QKALECFCQAASEVGKEEFL-DRLIRS-----------EDGEIVSTPR------LQYYDKVLRLL 970

  Fly   940 EQHSALDYIIQLADMAIRVLQPDDPQLPMFQSIVFNNHLQLGHYVEAYTALVNNADISRRKDCLR 1004
            :.....:.:||||..||.....|.......::.:|.:||.|||..:||.||....|.||:.||||
Human   971 DVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLR 1035

  Fly  1005 QLVITLFQNKCLPLLMQFSYIGLQDEFESIVESRARSMSIDQNEVYNFLYAFHTNKGNMRKASTV 1069
            |||:.|.:...|..|::|.|:.|.:|...|:|||||::.:..:..|..|||||..:.|.|||.||
Human  1036 QLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTV 1100

  Fly  1070 MYEQAMRFQVDSDAPNALEKRCSSLLICLNCLHLVDSRYRWIAKPVLGD--EQVITIDQDNDDGE 1132
            |:|..||...:......|||:.:..|..||||.|:...|.||.:||.|.  ::.....:.|.|||
Human  1101 MFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYAWIVQPVSGAVYDRPGASPKRNHDGE 1165

  Fly  1133 PKCDEDKRGQEVVVLELADIRRELVHAEALRELSFYRKDTAAYERA---TPEELSYLLASSGLYT 1194
              |......:::.:|||.|:.:|...|..  .|:..:.|.:|...|   :.||:..||..:||:.
Human  1166 --CTAAPTNRQIEILELEDLEKECSLARI--RLTLAQHDPSAVAVAGSSSAEEMVTLLVQAGLFD 1226

  Fly  1195 AALKLSRGHSFSVLPIFESLTSACVA---ATEDKSSDAWNWLQNNDMADL--PHRSNAADMAW-- 1252
            .|:.|.:.....:.|:||.|...|:.   ..|...::||.||..|.::.:  ...|:|.|.||
Human  1227 TAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAAQAEAWAWLAANQLSSVITTKESSATDEAWRL 1291

  Fly  1253 --TLLQKLVVDNEAKDSTLIRKSVVQRLLGLNAFLPQWLINSYKLSHSRELLHLLVKHNRLLEAA 1315
              |.|::..|.|     .|....|:.:||.....||.|||||||...:.|||.|.:.::.|.||.
Human  1292 LSTYLERYKVQN-----NLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAV 1351

  Fly  1316 DLGCEIIAGMLGAGSEYFEFKHAVNIANPQLCFPISTIDLLLHGLKINGKDDLDYEMAYFKLEEE 1380
            ||..|.:..:||.|.:||..:..::...|.:..|.|:||.||..|..|..:..:..::. |:.::
Human  1352 DLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIALSQ-KILDK 1415

  Fly  1381 VQRYIETIKRTTDDKMSMAVLQMRT 1405
            ::.|.:.:.:.|.|     :|..||
Human  1416 LEDYQQKVDKATRD-----LLYRRT 1435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nup160	NP_001285832.1	Nup160	28..530	CDD:288551	154/538 (29%)
NUP160	NP_056046.1	Nup160	62..577	CDD:288551	154/538 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C348840901
eggNOG	1	0.900				E1_KOG4521
Hieranoid	1	1.000
Homologene	1	1.000				H32509
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D284127at2759
OrthoFinder	1	1.000				FOG0003982
OrthoInspector	1	1.000				T1074326
orthoMCL	1	0.900				OOG5_132810
Panther	1	1.100			LDO	PTHR21286
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R4695
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	14	13.800