DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup160 and NUP160

DIOPT Version :9

Sequence 1:	NP_001285832.1	Gene:	Nup160 / 34549	FlyBaseID:	FBgn0262647	Length:	1411	Species:	Drosophila melanogaster
Sequence 2:	NP_056046.2	Gene:	NUP160 / 23279	HGNCID:	18017	Length:	1402	Species:	Homo sapiens

Alignment Length:	1455	Identity:	420/1455 - (28%)
Similarity:	688/1455 - (47%)	Gaps:	186/1455 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LKTFETSGGYCYKNTKNV--QTRNRFIYWRTYQDVLELSEVSLDISLQRNHLRLRFTDSAVL--N 101
            :|..|::||:.|..:..:  .||||||:|:|..|.|||.|.||||:|..|.:||:|.:.:||  .
Human    43 VKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLDINLLNNAIRLKFQNCSVLPGG 107

  Fly   102 VSLTEQGTSVTLLVVTVSSVHRYVFP---------LKVAGQEGGAASPEDLLSQSIFYDVNDKIN 157
            |.::|....|.:|::|..:|||.:.|         |.|..|           .||||.|:. |::
Human   108 VYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVDSQ-----------MQSIFTDIG-KVD 160

  Fly   158 --DPSTYYVTDGF-GTMPN--AAVSYLTQDSQSAYFAVAYQSKLLLHVMKCS----TGHTITHEI 213
              ||..|.:.... |..||  |:.::|:.|.: |.||:...|..:. |:|..    .|.....|:
Human   161 FTDPCNYQLIPAVPGISPNSTASTAWLSSDGE-ALFALPCASGGIF-VLKLPPYDIPGMVSVVEL 223

  Fly   214 KEPKLMPWFLSN-LKGALTGRSETLEAATSMAFSEIGGEIFILVLYRNNELRLWS---------V 268
            |:..:|...|:. :..|:.|.....:...|:|...:..:.||..|.::::||:||         .
Human   224 KQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIFALCQDHKLRMWSYKEQMCLMVA 288

  Fly   269 DNLQTVASINCSTELGQDSAAQGPQNSQLRKISDQNFCLFLSHN--------------SRAEFIC 319
            |.|:.|                 |....||..:.....|.|:::              .|.:|..
Human   289 DMLEYV-----------------PVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYMHAPKRGQFCI 336

  Fly   320 VSIMPDADDASVINLVQNMVPAPQTDLVDFDATSSHIWALWSNAEGDFHVSAAYFASNNAIKWVS 384
            ..::....:...::.:.::..:.:| |:||..||:.|||||.:||....|....|..|.|.:|..
Human   337 FQLVSTESNRYSLDHISSLFTSQET-LIDFALTSTDIWALWHDAENQTVVKYINFEHNVAGQWNP 400

  Fly   385 AALEPPPDRYCLTMEQGVDPRETYCSYIFHPGRFDRNVIAKALYMFRR---VNLQFDVKQLSMSV 446
            ..::|.|:.. :.:....||||.|...:|.||:|....:.|||.:|.|   .||     .||.|.
Human   401 VFMQPLPEEE-IVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFCRGTERNL-----DLSWSE 459

  Fly   447 LKEQVCQAVEDEIQNELKDFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTGLAVLGGMDAVC 511
            ||::|..|||:|:|..:.::..:.||:..:....|.:||:||.||...||.|..|.:....:.||
Human   460 LKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQEALSHPLALHLNPHTNMVC 524

  Fly   512 LVRRQSFALLRPCEVLEHLLLIGEHN----DEVATYVAPLFRNDPEMAKGFVELMNVVTLLDKLI 572
            |:::...:.|.|..:::||.|:...|    ||..      ..:|.::|:..:.|:..:.|:::.:
Human   525 LLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETT------ISDDVDIARDVICLIKCLRLIEESV 583

  Fly   573 SEDIKIELDKQLYQRESPVEVISKLVARISMIDDNGPILPSNCVRQIQQKLQNIPNLEPALEML- 636
            :.|:.:.::...|..:||.:...:::..:..||      ..|.:..|..|||.|.|...|:.:|
Human   584 TVDMSVIMEMSCYNLQSPEKAAEQILEDMITID------VENVMEDICSKLQEIRNPIHAIGLLI 642

  Fly   637 --LDVLCMIDPDE---PPHDYSLSTRFLQSSGALMGSEYGLSILSETVKQMAMIRFSVCRNLLVL 696
              :|....::.::   |....::.....|    |.||.....|:...|.::|..||.:||:||:|
Human   643 REMDYETEVEMEKGFNPAQPLNIRMNLTQ----LYGSNTAGYIVCRGVHKIASTRFLICRDLLIL 703

  Fly   697 QYM----------AYGQNEMESENVL-TNLNYLNSYYTLVWIAETPISSSTPAG-FEASIQRLSR 749
            |.:          ..||.....:::| .....|.|||.:.|.:|. :::..|.. .|:::|.||.
Human   704 QQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGSEC-LATDVPLDTLESNLQHLSV 767

  Fly   750 AQLF-SG---YNRPYSSHLKHNGNDQTTLLRLFLESKGLFSALTMLLKHDSLSLDSEQLNLRQSL 810
            .:|. ||   .||..||        ..|::.||.:.......::.|.......|....||..:.:
Human   768 LELTDSGALMANRFVSS--------PQTIVELFFQEVARKHIISHLFSQPKAPLSQTGLNWPEMI 824

  Fly   811 LQLVGYINKMLWPGSPIYVFPEWLFGTCHHIIVQDYVRILSNWCSVQKHARRFMLAVSLLDCGEA 875
            ..:..|:.::|||.:|..:|.|.|.|.|.::.:|||:::|..||.|...:.||||....|..||.
Human   825 TAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHPWCQVNVGSCRFMLGRCYLVTGEG 889

  Fly   876 HKAVHLFHEAESGIVEDDFLFEHVLKNTPLYGKLQNSVSRGDTIS-PEDTKLAIVHYYLKVIQLF 939
            .||:..|.:|.|.:.:::|| :.::::           ..|:.:| |.      :.||.||::|.
Human   890 QKALECFCQAASEVGKEEFL-DRLIRS-----------EDGEIVSTPR------LQYYDKVLRLL 936

  Fly   940 EQHSALDYIIQLADMAIRVLQPDDPQLPMFQSIVFNNHLQLGHYVEAYTALVNNADISRRKDCLR 1004
            :.....:.:||||..||.....|.......::.:|.:||.|||..:||.||....|.||:.||||
Human   937 DVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEALTQIPDSSRQLDCLR 1001

  Fly  1005 QLVITLFQNKCLPLLMQFSYIGLQDEFESIVESRARSMSIDQNEVYNFLYAFHTNKGNMRKASTV 1069
            |||:.|.:...|..|::|.|:.|.:|...|:|||||::.:..:..|..|||||..:.|.|||.||
Human  1002 QLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNYRKAGTV 1066

  Fly  1070 MYEQAMRFQVDSDAPNALEKRCSSLLICLNCLHLVDSRYRWIAKPVLGD--EQVITIDQDNDDGE 1132
            |:|..||...:......|||:.:..|..||||.|:...|.||.:||.|.  ::.....:.|.|||
Human  1067 MFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYAWIVQPVSGAVYDRPGASPKRNHDGE 1131

  Fly  1133 PKCDEDKRGQEVVVLELADIRRELVHAEALRELSFYRKDTAAYERA---TPEELSYLLASSGLYT 1194
              |......:::.:|||.|:.:|...|..  .|:..:.|.:|...|   :.||:..||..:||:.
Human  1132 --CTAAPTNRQIEILELEDLEKECSLARI--RLTLAQHDPSAVAVAGSSSAEEMVTLLVQAGLFD 1192

  Fly  1195 AALKLSRGHSFSVLPIFESLTSACVA---ATEDKSSDAWNWLQNNDMADL--PHRSNAADMAW-- 1252
            .|:.|.:.....:.|:||.|...|:.   ..|...::||.||..|.::.:  ...|:|.|.||
Human  1193 TAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAAQAEAWAWLAANQLSSVITTKESSATDEAWRL 1257

  Fly  1253 --TLLQKLVVDNEAKDSTLIRKSVVQRLLGLNAFLPQWLINSYKLSHSRELLHLLVKHNRLLEAA 1315
              |.|::..|.|     .|....|:.:||.....||.|||||||...:.|||.|.:.::.|.||.
Human  1258 LSTYLERYKVQN-----NLYHHCVINKLLSHGVPLPNWLINSYKKVDAAELLRLYLNYDLLEEAV 1317

  Fly  1316 DLGCEIIAGMLGAGSEYFEFKHAVNIANPQLCFPISTIDLLLHGLKINGKDDLDYEMAYFKLEEE 1380
            ||..|.:..:||.|.:||..:..::...|.:..|.|:||.||..|..|..:..:..::. |:.::
Human  1318 DLVSEYVDAVLGKGHQYFGIEFPLSATAPMVWLPYSSIDQLLQALGENSANSHNIALSQ-KILDK 1381

  Fly  1381 VQRYIETIKRTTDDKMSMAVLQMRT 1405
            ::.|.:.:.:.|.|     :|..||
Human  1382 LEDYQQKVDKATRD-----LLYRRT 1401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup160	NP_001285832.1	Nup160	28..530	CDD:288551	153/537 (28%)
NUP160	NP_056046.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141200
Domainoid	1	1.000	342	1.000	Domainoid score	I1081
eggNOG	1	0.900	-	-		E1_KOG4521
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32509
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1269
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45584
OrthoDB	1	1.010	-	-		D284127at2759
OrthoFinder	1	1.000	-	-		FOG0005509
OrthoInspector	1	1.000	-	-		oto89593
orthoMCL	1	0.900	-	-		OOG6_104899
Panther	1	1.100	-	-	LDO	PTHR21286
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4695
SonicParanoid	1	1.000	-	-		X5111
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800