DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nup160 and nup160

DIOPT Version :9

Sequence 1:	NP_001285832.1	Gene:	Nup160 / 34549	FlyBaseID:	FBgn0262647	Length:	1411	Species:	Drosophila melanogaster
Sequence 2:	XP_031756356.1	Gene:	nup160 / 105947166	-ID:	-	Length:	1439	Species:	Xenopus tropicalis

Alignment Length:	1445	Identity:	423/1445 - (29%)
Similarity:	698/1445 - (48%)	Gaps:	122/1445 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SYREVI--PRNLSPAEWIEVKINTGTQSTLQDLKTFETSGGYCYKNTKNV--QTRNRFIYWRTYQ 71
            ||.|:|  .|..|...:.::.:.......:...|..:.:|||||..:.::  .||||||:|.:|.
Frog    45 SYMELIGAERETSRRNFRDLSLRPDVSLVIGGPKYSDCAGGYCYNESGSLLSATRNRFIHWTSYA 109

  Fly    72 DVLELSEVSLDISLQRNHLRLRFTDSAVL--NVSLTEQGTSVTLLVVTVSSVHRYVFPLKVAGQE 134
            |.|||.|:||||:|..|.:||:..:.::|  .|.:.|...::.:|::|..:|||.:.|.......
Frog   110 DTLELVELSLDINLLNNAVRLKILNCSILPGGVHICETQNNIIVLILTNQTVHRLILPHPSRMYR 174

  Fly   135 GGAASPEDLLSQSIFYDV-NDKINDPSTYYVTDGF-GTMPN--AAVSYLTQDSQSAYFAVAYQSK 195
            ....|...:  ||||.|: ....:||:..||.... |..||  |:.::|:.|.::.:...:....
Frog   175 SEIISDSHI--QSIFTDIGKTNFHDPNNTYVIPAIPGRAPNSTASTAWLSSDGEALFALPSVSGG 237

  Fly   196 LLLHVM--KCSTGHTITHEIKEPKLMPWFLSN-LKGALTGRSETLEAATSMAFSEIGGEIFILVL 257
            :|:..|  :...|.....|:|:..:|...|:. :..::.|.........|:|...:..:.::..|
Frog   238 ILVIKMPPRDMEGLVTIAELKQSSVMQRLLTGWMPSSIRGDPGPAHLPVSLAVHTLDHDSYLFAL 302

  Fly   258 YRNNELRLWSVDNLQTVASINCSTELGQDSAAQGPQNSQLRKISDQNFCLFLSHNSRAEFICVSI 322
            .::::||:||..:...:        :..|.....|.:..:|:.:.....|.|:::...|.:.:.:
Frog   303 CQDHKLRMWSYKDQMCL--------MVADMLEYVPVSKDIRQTAGTGHKLRLAYSDTLEILYLGV 359

  Fly   323 ---MPDADDASVINLV-----------QNMVPAPQTDLVDFDAT--SSHIWALWSNAEGDFHVSA 371
               .|......|..||           .:.:...|..|:||..|  |.:|||||.:.:....:..
Frog   360 YLHTPRQGQFCVFQLVCTESNRYSLEHTSSIFTNQETLIDFTFTLSSMNIWALWLDDDNQTVMKH 424

  Fly   372 AYFASNNAIKWVSAALEP-PPDRYCLTMEQGVDPRETYCSYIFHPGRFDRNVIAKALYMFRRVNL 435
            ..|..|.|..|....:.| |.|...:..||  :|:|.|...:|.||||....:.||:.:.|:.:.
Frog   425 INFERNQAGHWNPVFVNPLPDDDLAIGDEQ--EPQEAYLECLFAPGRFTIAALQKAIQILRKGSG 487

  Fly   436 QFDVKQLSMSVLKEQVCQAVEDEIQNELKDFVVTDEEYLEISTRLWDRFYSCCEQYHIKLSEPTG 500
            :  |..||...||::|...||.||||.:.|:.|:.||:.:|:...|.:||:||.||...||.|..
Frog   488 R--VLDLSWEELKKEVTLTVEKEIQNAVVDYDVSQEEFRQINIENWCKFYTCCLQYQETLSRPLA 550

  Fly   501 LAVLGGMDAVCLVRRQSFALLRPCEVLEHLLLI-GEHNDEVATYVAPLFRNDPEMAKGFVELMNV 564
            |.|....:.|||:|:...:.|.||..:|||.|: |||   :.|....:..:|.:.|...|.|:..
Frog   551 LVVHPNTNMVCLLRKGFLSFLAPCSSVEHLYLVPGEH---LLTVDESVICDDVDGASDIVSLIQC 612

  Fly   565 VTLLDKLISEDIKIELDKQLYQRESPVEVISKLVARISMIDDNGPILPSNCVRQIQQKLQNIPNL 629
            :.::...|:||:..:::......:||..|..:::..:...|.:      |.:..||.|||:|.|.
Frog   613 LHMIADYITEDMAYQMESACCHPQSPERVAEQILEDLIANDID------NIMENIQNKLQDIRNP 671

  Fly   630 EPALEMLL---DVLCMIDPDEPPHDYSLSTRFLQSSGALMGSEYGLSILSETVKQMAMIRFSVCR 691
            ..|:..||   |....:|.::..|:..|:.      ..|.||....|::.:.:.:::..||.:||
Frog   672 IQAISFLLQNMDYETNMDMEQSQHNVRLNL------STLYGSVTASSVVCQAIYKISATRFLICR 730

  Fly   692 NLLVLQYMAYGQNEM-----------ESENVLTNLNYLNSYYTLVWIAETPISSSTPAG-FEASI 744
            :||:||::.....:|           :.|.:......|.|||.:.|.::. ::.:.|.. .|:::
Frog   731 DLLILQHLLLRLGDMALVGAGQLLHSQQELIPRAAQLLLSYYMIRWGSQC-LACAVPVDLLESNL 794

  Fly   745 QRLSRAQLFSGY--NRPYSSHLKHNGNDQTTLLRLFLESKGLFSALTMLLKHDSLSLDSEQ---- 803
            |.||..:|....  .|.|:|.::       |::.||.|..|. .....:..|..:...|.|
Frog   795 QHLSVLELSDSQVEKRRYTSGIQ-------TIVELFFEDVGR-KHFPQVFAHLFIQSGSSQVHRS 851

  Fly   804 LNLRQSLLQLVGYINKMLWPGSPIYVFPEWLFGTCHHIIVQDYVRILSNWCSVQKHARRFMLAVS 868
            ||....:.::..|:.::|||.:|.:.|.|.|...|.:..:|:|||:|..||.|...:..||||..
Frog   852 LNWADLIHRITSYLLQLLWPSNPNFQFAECLMRNCQYTQLQEYVRLLLPWCQVNVGSCHFMLAQC 916

  Fly   869 LLDCGEAHKAVHLFHEAESGIVEDDFLFEHVLKNTPLYGKLQNSVSRGDTISPEDTKLAIVHYYL 933
            .|..||.|||:..|.:|.|.:..:||| |.:::           |..|:::||.      :.||.
Frog   917 YLVAGEGHKALDCFSQAASEVEREDFL-EKLIR-----------VEEGESVSPR------LQYYN 963

  Fly   934 KVIQLFEQHSALDYIIQLADMAIRVLQPDDPQLPMFQSIVFNNHLQLGHYVEAYTALVNNADISR 998
            :|::|.|.....:.:||||.:||.....|.......::.:|.:||.:||..:||.||....|.||
Frog   964 RVLRLLEDVGLPELVIQLATIAISEASDDWRSQAALRTRIFKHHLDMGHNSQAYDALTQIPDTSR 1028

  Fly   999 RKDCLRQLVITLFQNKCLPLLMQFSYIGLQDEFESIVESRARSMSIDQNEVYNFLYAFHTNKGNM 1063
            :.|||||||:.|.:...|..|::|.|:.|.:|...|:|||||::.:..:..|..|||||..:.|.
Frog  1029 QLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNYYELLYAFHIYRHNY 1093

  Fly  1064 RKASTVMYEQAMRFQVDSDAPNALEKRCSSLLICLNCLHLVDSRYRWIAKPVLGD--EQVITIDQ 1126
            |||.|||:|..||...:......|:|:.:|.|.|||||.|:...|.||.:||.|.  |:.....:
Frog  1094 RKAGTVMFEYGMRLGREVRTLRGLQKQVNSYLACLNCLRLIRPEYAWIVQPVSGAVYERPGASPK 1158

  Fly  1127 DNDDGEPKCDEDKRGQEVVVLELADIRRELVHAEALRELSFYRKDTAAYE-RATPEELSYLLASS 1190
            .|.|||......  ..::.:|||.|:.:|.|.|:....|:.:...|||.. .:..||:..||..:
Frog  1159 RNYDGESSAVPS--SSQIEILELRDLEKEYVLAQTRLTLAKHNPSTAAIAGSSAAEEMVALLVQA 1221

  Fly  1191 GLYTAALKLSRGHSFSVLPIFESLTSACV---AATEDKSSDAWNWLQNNDMADL--PHRSNAADM 1250
            ||:..|:.|.:.....:..|||.|...|:   ...|...::||.||..|.:|.:  ...|:|.|.
Frog  1222 GLFDTAISLCQTFKLGLTSIFEGLACKCIRLQQGGEAAQAEAWEWLAANQLATVITTKESSATDE 1286

  Fly  1251 AWTLLQKLVVDNEAKDSTLIRKSVVQRLLGLNAFLPQWLINSYKLSHSRELLHLLVKHNRLLEAA 1315
            ||.|:...:...|:| :||....::.:||.....||.||||.||...:.|||.|.:|::.|.|||
Frog  1287 AWRLMISYLDKYESK-NTLYHHCIINKLLSHGVPLPNWLINRYKAMDAAELLRLYLKYDLLEEAA 1350

  Fly  1316 DLGCEIIAGMLGAGSEYFEFKHAVNIANPQLCFPISTIDLLLHGLKINGKDDLDYEMAYF-KLEE 1379
            :|..|.:..:||.|.:||..:..::..:..:.||.|.||.|  .|.:...::..:..|.. ||:.
Frog  1351 ELVLEYVDALLGKGHQYFGIQAPLSATSQLVWFPYSAIDHL--RLALGENENNQHNQAILGKLQR 1413

  Fly  1380 EVQRYIETIKRTTDD 1394
            ::..|.:.:|:.|||
Frog  1414 KMDEYFQKLKKATDD 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nup160	NP_001285832.1	Nup160	28..530	CDD:288551	145/529 (27%)
nup160	XP_031756356.1	Nup160	83..580	CDD:403040	144/510 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284127at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010