DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Csl4 and Exosc1

DIOPT Version :9

Sequence 1:	NP_609492.1	Gene:	Csl4 / 34548	FlyBaseID:	FBgn0032346	Length:	204	Species:	Drosophila melanogaster
Sequence 2:	XP_011245614.1	Gene:	Exosc1 / 66583	MGIID:	1913833	Length:	212	Species:	Mus musculus

Alignment Length:	202	Identity:	92/202 - (45%)
Similarity:	132/202 - (65%)	Gaps:	20/202 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 CLPGERLCRTEDSIVLGIGTYEQNGYIYASKSG-IVNIEDSGD------------KCQVVSVHKP 62
            |:||||||..|:... |.|||.::|||::|.:| ::...::|.            :..||||.:.
Mouse    12 CIPGERLCNLEEGSP-GSGTYTRHGYIFSSLAGCLMKTSENGAVKEAATQRAFPLRVPVVSVMRE 75

  Fly    63 GFHLTIPATGDVVTARVLVTTPKFAKCAIFCVRNVLLESSYRGLLRKEDVRETEKDRVDIYKSFR 127
            .....:|..|.|||.:|.....:|||..|..|.:..|::::||.:||||:|.||||:|:||||||
Mouse    76 TESQLLPDVGAVVTCKVSSINSRFAKVHILYVGSTPLKNAFRGTIRKEDIRATEKDKVEIYKSFR 140

  Fly   128 PGDVILARVIN--QLEQSFLLTTAENELGVVIAYASDYRKTRVPMVPVGWSEMQCPQTTIKEPRK 190
            |||::||:||:  ..:.::||||||||||||:|::    ::.|.|||:.|.|||||:|..||.||
Mouse   141 PGDIVLAKVISLGDAQSNYLLTTAENELGVVVAHS----ESGVQMVPISWCEMQCPKTHTKEFRK 201

  Fly   191 VAKVLPE 197
            ||:|.||
Mouse   202 VARVQPE 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Csl4	NP_609492.1	Csl4	10..193	CDD:224021	88/196 (45%)
		ECR1_N	10..47	CDD:291080	17/36 (47%)
		S1_CSL4	66..156	CDD:240217	47/91 (52%)
Exosc1	XP_011245614.1	Csl4	14..203	CDD:224021	86/193 (45%)
Exosc1	XP_011245614.1	S1_CSL4	79..171	CDD:240217	47/91 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842824
Domainoid	1	1.000	67	1.000	Domainoid score	I9845
eggNOG	1	0.900	-	-		E1_COG1096
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9359
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4129
Isobase	1	0.950	-	0	Normalized mean entropy	S1914
OMA	1	1.010	-	-		QHG55393
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004386
OrthoInspector	1	1.000	-	-		oto95347
orthoMCL	1	0.900	-	-		OOG6_101821
Panther	1	1.100	-	-	LDO	PTHR12686
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R252
SonicParanoid	1	1.000	-	-		X4766
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740