DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(2)gd1 and cc2d1b

DIOPT Version :9

Sequence 1:	NP_001245976.1	Gene:	l(2)gd1 / 34543	FlyBaseID:	FBgn0261983	Length:	834	Species:	Drosophila melanogaster
Sequence 2:	XP_004914063.2	Gene:	cc2d1b / 100489497	XenbaseID:	XB-GENE-997988	Length:	864	Species:	Xenopus tropicalis

Alignment Length:	868	Identity:	291/868 - (33%)
Similarity:	461/868 - (53%)	Gaps:	106/868 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IPDDFDPSAGYGEDDGGDSDLEAELAAITGGEGA-KPKPKPKAKLLPASDLDKMIADSLRDVSDD 88
            ||||        .||..|.||||||||:||.:.| |||||.||. ||..|::||..|.::|...:
Frog    39 IPDD--------PDDPDDGDLEAELAALTGVKAASKPKPKGKAP-LPMEDIEKMAQDCMKDTIGE 94

  Fly    89 DDDDNLESDPDLLGELSGIGGLEEAEEEEPVAQPPAASEEP------------------VQTFLP 135
            |||::||.|.:||.||..:.|.:|.||.|.:....|...||                  :|..|.
Frog    95 DDDEDLEGDEELLAELQEVVGDDEEEEMEQLRPSNAEELEPPLPDILESGQQVNSSATEIQHHLQ 159

  Fly   136 TTTVDTLSIIKQRLEMYKQAEANAKTAGDSGKARRFGRGLKTLKDLHRQAAAGKSINVDDIPPEV 200
            ........::::|:..||:|.:|||.:.:|.||||:.||||||:.:......|:::...||||.|
Frog   160 APAEGMFQVLEERIRNYKEAISNAKLSNESAKARRYERGLKTLESMLHTVKQGRAVIEADIPPPV 224

  Fly   201 SV-KPIGGQAPPVPAEES-----------PAPSTPA------SPPPVPSRAAPDPPTPGTPVEPT 247
            :. ||.......||..::           |..:|.|      |..||......|    |..|:.|
Frog   225 ACGKPAVSPKTDVPTTDTSKEEVEDLNHVPMETTEAATNLDSSEDPVSKAITND----GGAVDKT 285

  Fly   248 TSVAPTSPPNPLVTQMRSRQTDYKAAALQSKRSGDISTALQFLKVVKQFDVVIKMCEDGQEVDLS 312
            .. ||.:..:| .|.:..||.:||.|||:||::|:|..|.:::::.|:|.||::..|.||.||||
Frog   286 HG-APQNDTDP-KTLLLQRQREYKLAALKSKQTGNIEKAKEYMRISKKFSVVLEALESGQPVDLS 348

  Fly   313 DMPPPPAEFLEFLKKMQEEAAAEAVAEPTAAPEPTPVAPAPVLAAATNMLEALQQRLEKYQSVEA 377
            :||..|.:....:.:      ::..|.||.|| |.||:....|:|. ::|:|||||:|||:|...
Frog   349 NMPAAPEDHDTMVTE------SKIPAHPTPAP-PVPVSNTQGLSAG-SLLQALQQRMEKYKSAAQ 405

  Fly   378 AAKAENNSGKARRFGRIVKQYEDAIKLYKAGKPVPYDELPVPPGFGPLPTADAAPVAPTPSLPTS 442
            .||:..:..|||...||.|||:|||:.:|||:.|...||||||||.|||..:  ......|:..:
Frog   406 QAKSSGDDRKARMHERIAKQYQDAIRAHKAGRQVNLAELPVPPGFPPLPGME--QTEEEGSVEKA 468

  Fly   443 PTSPPPTASTSAGGTPSSSSATTPTAPRKAPSPPKPKELT-------------------TRTSGN 488
            ..:....|.| ||...............|.|..|||.:|.                   .:|:..
Frog   469 LEAAQKLAKT-AGNEEDDDDGEEGECQAKPPGHPKPTQLVKPMPAVSDSEETSLTNKAPVKTASE 532

  Fly   489 QQKNNIAEQQMKLLLERQKEFKLAAIEAKKAGEIDQAKEYLKIFKGFDSLLNAASSGLPVDLSTL 553
            ::.....::|::.|..|:|:::.||::||:..:::|||:::::.......::...||..||:|.:
Frog   533 EKLPPAVQEQLEFLEHRKKQYRKAALQAKQKNDLEQAKQHMRVAHTLQVSIDQVRSGKLVDISKV 597

  Fly   554 PVPPSQRDNLEASFAIVSAEECDPTDDICEIGVRMEEQLAKQLMMCKNTRDHHKAMGDVAGMNRF 618
            |..|   |:.|:.|.:|..|:.....:..::...:.:.|.:|...|.........||:||...||
Frog   598 PSLP---DDEESDFVVVEHEDIKTPQNSEDVYSMLLKLLHEQHEKCIRYSKQFTQMGNVAETTRF 659

  Fly   619 ENLALTVQKDLDLVRYSKRKNEPLPKFHYEKRSFNIVHCNTDLTDSELEIVVVRGISYNVAN--- 680
            |.:|...:|:.::::.|:.:....|.:|:|.::..||...::|:.:|:.:::||||:....:
Frog   660 EKMAEDCKKNCEILQLSQAQGLDPPPYHFEDKTLKIVRVFSELSSTEMLLIIVRGINLPAPSGVA 724

  Fly   681 PKDVDTYVRVEFPLLNDES-FKTKTNVIRDTSSPDYDERFKVDIQRTNRQFQRIFKRHGVKFEIY 744
            |.|:|.||:.|||..:.|. .|.||.||::|:||:|:..||::|.|.:|.|:|:.:..|:||||:
Frog   725 PNDLDAYVKFEFPYPSSEQPQKNKTLVIKNTNSPEYEHSFKLNINRNHRGFKRVIQTKGIKFEIF 789

  Fly   745 SRGCSIDCCGLSRKLPLCCFRGFLRSDTLIGTVNVKLQPLETKCEIHDTYDLMDGRKQVGGKLEV 809
            .:|..:                 :|||..:||.:|||..|||:|||.:..::.||||..|||||:
Frog   790 HKGFFL-----------------VRSDKQVGTASVKLDKLETQCEIREIVEVFDGRKPTGGKLEI 837

  Fly   810 KIRVRNPILTKQMEHITEKWLVL 832
            |:|:|:|:..:.::.:||||||:
Frog   838 KVRLRDPLNGQDLQVVTEKWLVM 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(2)gd1	NP_001245976.1	DM14	142..200	CDD:128928	23/57 (40%)
		DM14	260..318	CDD:128928	26/57 (46%)
		DM14	362..420	CDD:128928	31/57 (54%)
		DM14	499..557	CDD:128928	16/57 (28%)
		C2_Freud-1	661..832	CDD:176072	69/174 (40%)
cc2d1b	XP_004914063.2	DM14	169..224	CDD:128928	23/54 (43%)
		DM14	297..354	CDD:128928	26/56 (46%)
		DM14	390..443	CDD:128928	27/52 (52%)
		DM14	543..601	CDD:128928	16/57 (28%)
		C2_Freud-1	702..860	CDD:176072	69/174 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	327	1.000	Domainoid score	I1179
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	452	1.000	Inparanoid score	I1568
OMA	1	1.010	-	-		QHG49459
OrthoDB	1	1.010	-	-		D408012at33208
OrthoFinder	1	1.000	-	-		FOG0003388
OrthoInspector	1	1.000	-	-		otm48559
Panther	1	1.100	-	-	O	PTHR13076
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2281
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.080