Protein Alignment Reps and Eps15l1

DIOPT Version :10

• Sequence 1: NP_609487.2
• Gene: Reps / 34542
• FlyBaseID: FBgn0032341
• Length: 907
• Species: Drosophila melanogaster
• Sequence 2: XP_006509607.1
• Gene: Eps15l1 / 13859
• MGIID: 104582
• Length: 923
• Species: Mus musculus
• Alignment Length: 1017
• Identity: 192/1017 - (18%)
• Similarity: 303/1017 - (29%)
• Gaps: 361/1017 - (35%)

  Fly     3 VSLTEPETRFYSELFQCCDVEKTGKVPMLKATELFRSADIANETVIEITGL------------AG 55
            :|||.|..:|:.........:.:.:.......|.....|...|:::.:.||            :.
Mouse    94 LSLTMPPPKFHDTSSPLMATQSSAETHWAVRVEEKAKFDGIFESLLPVNGLLSGDKVKPVLMNSK 158

  Fly    56 IPSTAL-------------HISRTQFYSCLKLIAAHQAAMPLRQELILATFPLPLPHFSWKEAVT 107
            :|...|             |:.|.:|     .:|.|.....|.:|        |:|
Mouse   159 LPLDVLGRVWDLSDIDKDGHLDRDEF-----AVAMHLVYRALEKE--------PVP--------- 201

  Fly   108 APVAVENGLTALPPP--PPTDRRNSLRRNSQQEQLQDTSDVPSTDSEVEQNESVDDATGHGRGTD 170
                     :.||||  ||:.|:.::...:          ||...:.....:|:.....||
Mouse   202 ---------SILPPPLIPPSKRKKTVFAGA----------VPVLPASPPPKDSLRSTPSHG---- 243

  Fly   171 GCGVVSSSSRENVGRRRGGGTGGGSPEAWSTNSDSPTPTNSVAERPWAQDTLWQGLLGDEHRQLL 235
                 |.||..:.|                    |.:|.:||.:.|.|    |...:.|:.|
Mouse   244 -----SVSSLNSTG--------------------SLSPKHSVKQPPVA----WVVPVADKMR--- 276

  Fly   236 GTEEESSDRHSSDDDDNESELVTIYQITPEQREYYNKQFRTVQRDPHGLLSGQAARNFFEKSRIP 300
                                              :::.|.....|..|.:|||..:..|..|.:.
Mouse   277 ----------------------------------FDEIFLKTDLDLDGYVSGQEVKEIFMHSGLT 307

  Fly   301 VEELRHIWQLCDVTRDGALSLSEFTAAMHLVVLRRNNIPLPTSLPHCLHPNVL------------ 353
            ...|.|||.|.|..:.|.||..:|..||:.:   :..:......|..|.|:::
Mouse   308 QNLLAHIWALADTRQTGKLSKEQFALAMYFI---QQKVSKGIDPPQVLSPDMVPPSERGTPIPDS 369

  Fly   354 -QAAASGSGQGVTS-----------------------SSSAALPQEPPEADLLHLNDDDEDDHTD 394
             ...|||...||..                       ....|:.|:..|...|. ||.|.:
Mouse   370 SSTLASGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQ-NDLDRE---- 429

  Fly   395 NTIIAGNLSGSSTTSKPR-----------PNVPSD------KNIMNLSSISTSSQASNSSKREAT 442
             |.....|......::.|           .::.||      .....:||:.|..|:..|..:...
Mouse   430 -TSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQTISSLKTQIQSQESDLKSQE 493

  Fly   443 PQNSLGK---NRSISNSPNVEKPVSG------TV--SSTASAVDSTNVSSQWTKFSESPTTSAVS 496
            ...:..|   ||.......:|:.:..      |:  |...:..|.....|:.::..||...:..|
Mouse   494 DDLNRAKSELNRLQQEETQLEQSIQAGRAQLETILRSLKCTQDDINQARSKLSQLQESHLEAHRS 558

  Fly   497 VQSTTGAAPVVAAGAAASGASSPGL------------------------KPVLFDMKRSAQDVVS 537
            ::........|      ||.|.|.|                        |.:||.         :
Mouse   559 LEQYDQVPDGV------SGTSLPDLATLNEGILLAERGGFGAMDDPFKNKALLFS---------N 608

  Fly   538 NPQILHPVPLRVTPIGTAIASSAESSNENESAVAQREDSPKAISSTTVNNQSSAVVPGISGVAGS 602
            |.|.|||.|.:        |.....|:..:.|...:.|..:  |......|::|..|    ..|.
Mouse   609 NSQELHPDPFQ--------AEDPFKSDPFKGADPFKGDPFQ--SDPFSEQQTAATDP----FGGD 659

  Fly   603 SHRDSSDLRAIQRPQAKKLPAKNSALPPPP-QREPSIGS-TGPSESQEPQAAYVASSLASKKEPP 665
            ..::|....:.......|...||......| .:.||:.| ..|.||.:|   :.:||::||...|
Mouse   660 PFKESDPFHSSSSDDFFKKQTKNDPFTSDPFTKNPSLPSKLDPFESSDP---FSSSSISSKGSDP 721

  Fly   666 PLPPPRPHRHARSSSLDLNKFKIGATGGAQQAEITAQASFDMQTSTGFADF-------------- 716
                        ..:||                  ...|....::.|||||
Mouse   722 ------------FGTLD------------------PFGSSSFSSAEGFADFSQMSKPPPSGPFSS 756

  Fly   717 ----THFADEGAANVVDEQQLHSLPPAAP-PPQAAVVPPTRITLQQAQQRVSAFEVY------RK 770
                |.|:|:...:   :|...:|||..| ||:..  ||:     :|........||      ..
Mouse   757 SLGGTGFSDDPFKS---KQDTPALPPKKPAPPRPK--PPS-----EAAAGEKGTVVYTLLGGQST 811

  Fly   771 PQTPRGSQSPPQQPPPPAPAVGLTTQ-------------TGQLPSAESFEKR--VTAISDSLRHV 820
            |.:..||...|:.|.|..| :|..:.             :|:.|.|.|...:  .|:.|......
Mouse   812 PVSQLGSSDFPESPDPFQP-LGADSGDPFQNKKGFGDPFSGKDPFAPSSSAKPPKTSSSGFADFT 875

  Fly   821 SF-----------KQGQANTTEVLQRLREQNNSLLHLCNDLS 851
            ||           ::.:....|.|.|||.|....|.|...||
Mouse   876 SFGNEEQQLAWAKRESEKAEQERLARLRRQEQEDLELAIALS 917

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Reps	NP_609487.2	EH	262..345	CDD:197477	20/82 (24%)
Eps15l1	XP_006509607.1	EH	13..103	CDD:197477	4/8 (50%)
		EH	121..200	CDD:197477	14/91 (15%)
		EH	266..362	CDD:197477	27/139 (19%)
		COG4372	363..>594	CDD:443500	39/242 (16%)