Protein Alignment piwi and Piwil4

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001423492.1
• Gene: Piwil4 / 689972
• RGDID: 1311015
• Length: 848
• Species: Rattus norvegicus
• Alignment Length: 872
• Identity: 288/872 - (33%)
• Similarity: 455/872 - (52%)
• Gaps: 60/872 - (6%)

  Fly     6 GRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPR-----------IEASRERRALEEA 59
            ||.|.|........::|.....||..:....|.||..|..|           :.:...||.|.|
  Rat     3 GRARVRARGITTGHSAREVERAPRDLMVTSVSPGDNEASSRTSVISQPHELGVSSGDGRRTLVE- 66

  Fly    60 PRREGGPTERKPWGDQYDYLN----TRPAELV----SKKGTDGVPVMLQTNFFRLKTKPEWRIVH 116
             :|..|         :.|:::    || .:|.    ||.|:.|:||.|.||.|.|....:|::..
  Rat    67 -KRGNG---------RQDFVDLGVCTR-EKLTHVKDSKTGSSGIPVQLATNLFHLDLPQDWQLYQ 120

  Fly   117 YHVEFEPSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIK 181
            |||.:.|.:.:.|:|..:|.||:.|......|||..||.:.|.:.::|.|:.:::.....||::.
  Rat   121 YHVTYSPDLASRRLRTALLYNHSILSDKAKAFDGTSLFLSEKLDHKVTELTSETQRGETVKITLT 185

  Fly   182 FVGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEK 246
            ....:....|..:|..|:|.|:..|.|::..:|||.:.|...:||.::|:.||||:..|:.:.|.
  Rat   186 LTSELFPNSPMCIQFFNVIFRKIFKKLSMYQIGRNYYKPSEPVEIPQYKLSLWPGFAISVSRFES 250

  Fly   247 DILLGTEITHKVMRTETIYDIM--------RRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRIN 303
            .:|...::.:||:|.||:.:.|        ..|.......|      ::.|||||.|||:||||:
  Rat   251 KLLFNADVNYKVLRNETVLEFMTDLCLRTDMSCFTETCHKQ------LVGLIVLTRYNNKTYRID 309

  Fly   304 DVDFGQTPKSTFSCK-GRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPEL 367
            |:|:...|...|..: |.:.::|:||..:|:|.:.|.|||:|:|..:.:....:..::|.|||||
  Rat   310 DIDWSVKPTHAFQKRDGSETTYVDYYKQQYDITLSDLNQPVLVSLLKRRRNDNSEPQMVHLIPEL 374

  Fly   368 CRVTGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTE 432
            |.:|||.::..|:|:||:|::..||::|..|..:|......:|....:...|..|.:.....::
  Rat   375 CFLTGLTSQATSDFRLMKAVAEETRLSPMGRQQQLARLADDIQRNQVTRFELETWGLHFGSQLS- 438

  Fly   433 VQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSL 497
            :.||::..:.|:..:........|||.:..|..::|:  |:.|:.|.::...|..|.:.:.|..|
  Rat   439 LTGRVVPSEKILLQDHTCQPAFAADWSKDMRSCKVLS--SEPLNTWLIVCCSRAEHLIESFLSCL 501

  Fly   498 YRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDR 562
            .|.....|..:..| :.|..|:....::||:...|..|.:|::|::|::....|.|||:....|.
  Rat   502 RRVGGSTGFSVGHP-KIIKVDENPAAFLRAIQLHVNPDVQLVMCILPSNQKNYYDSIKRYLSSDC 565

  Fly   563 AVPTQVVTLKTTKNRSLM-SIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAY 626
            .||:|.|..:|...:.:| |:|||||:|:.||||...|.:|:||..||.:|.||.:....:..|.
  Rat   566 PVPSQCVLTRTLNKQGMMLSVATKIAMQMTCKLGGELWAVEIPLKSLMVVGIDICRDALSKDVAV 630

  Fly   627 GALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQ-YQHEHRKLPSRIVFYRDGVSSG 690
            ...:||::.:....:...|.:.:|.|: |:.|...:..||.: |:|.| .||:||:.|||||.:|
  Rat   631 VGFVASINSRITRWFSRCVLQRTAADI-ADCLKVCMTGALNKWYKHNH-DLPARIIAYRDGVGNG 693

  Fly   691 SLKQLFEFEVKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNG----QNPPPGTIVDDVI 751
            .||.:.|:||..::..: ||......| .:|:.:||.:....|.|...    ||||.||:||...
  Rat   694 QLKAVLEYEVPQLLSSV-TECGSDARS-CRLSVVVVRKRCLLRLFAESGHTLQNPPLGTVVDSEA 756

  Fly   752 TLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQY 816
            |.||.|||||.||...:||||||.|||:|....|.|:.||:||:|:|||||||.|...|||.|||
  Rat   757 TRPEWYDFYLTSQTANRGTVSPTYYNVIYDDNALKPDHMQRLTFKLCHLYYNWQGVISVPAPCQY 821

  Fly   817 AKKLATLVGTNLHSIPQNALEKKFYYL 843
            |.||..||..::|..|...|..|.:||
  Rat   822 AHKLTFLVAQSIHKEPSLELANKLFYL 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	50/142 (35%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	159/449 (35%)
Piwil4	NP_001423492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/16 (25%)
		PAZ_piwi_like	265..381	CDD:239211	42/121 (35%)
		Piwi_piwi-like_Euk	389..831	CDD:240016	159/449 (35%)