DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment piwi and Ago2

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_038936150.1	Gene:	Ago2 / 59117	RGDID:	621255	Length:	860	Species:	Rattus norvegicus

Alignment Length:	868	Identity:	199/868 - (22%)
Similarity:	344/868 - (39%)	Gaps:	226/868 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSN-----HANLLGSGY-LFD 149
            ||.|..:.||.|||.:.. |:..|.||.::.:|.....||...::.:     ...:.|... :||
  Rat    33 GTTGRTIKLQANFFEMDI-PKIDIYHYELDIKPEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFD 96

  Fly   150 GLQ-LFTTR-------KFEQEITVLSGKSKLDIEYKISIKFVGFISC------------AEP-RF 193
            |.: |:|..       |.|.|:| |.|:.| |..:|:|||:|..:|.            :.| ..
  Rat    97 GRKNLYTAMPLPIGRDKVELEVT-LPGEGK-DRIFKVSIKWVSCVSLQALHDALSGRLPSVPFET 159

  Fly   194 LQVLNLILRRSMKGLNLELVGRNLF-------DPRAKIEIREFKMELWPGYETSIR--------- 242
            :|.|::::|. :..:....|||:.|       :|...      ..|:|.|:..|:|
  Rat   160 IQALDVVMRH-LPSMRYTPVGRSFFTASEGCSNPLGG------GREVWFGFHQSVRPSLWKMMLN 217

  Fly   243 ----------------------------QHEKDIL-------------LGTEITH--KVMRTETI 264
                                        :.:|.:.             |..||||  ::.|...:
  Rat   218 IDVSATAFYKAQPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHCGQMKRKYRV 282

  Fly   265 YDIMRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCKGRDISFVEYYL 329
            .::.||    ||.||                   |:.:.. :.|||.:.|.:         :|:.
  Rat   283 CNVTRR----PASHQ-------------------TFPLQQ-ESGQTVECTVA---------QYFK 314

  Fly   330 TKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCRVTG-------LNAEMRSNFQLMRA 386
            .::.:.:|..:.|         .|:....:....:| |:|.:..       |.....|......|
  Rat   315 DRHKLVLRYPHLP---------CLQVGQEQKHTYLPLEVCNIVAGQRCIKKLTDNQTSTMIRATA 370

  Fly   387 MSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVP 451
            .|:..|.....:..|..:||        :...:|::.:.:...:|:|.||::...:|::
  Rat   371 RSAPDRQEEISKLMRSASFN--------TDPYVREFGIMVKDEMTDVTGRVLQPPSILY------ 421

  Fly   452 AGENADWQRHFRDQRMLTTPSDG--------------LDRWAV--IAPQRNSHE--LRTLLDSLY 498
            .|.|          :.:.||..|              :..||:  .||||...|  |::..:.|.
  Rat   422 GGRN----------KAIATPVQGVWDMRNKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLR 476

  Fly   499 RAASGMGLRIRSPQEFIIY---DDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYV 560
            :.:...|:.|:....|..|   .|......|.:.: ..:..:|::.::|. ....|:.:|:.|..
  Rat   477 KISRDAGMPIQGQPCFCKYAQGADSVEPMFRHLKN-TYAGLQLVVVILPG-KTPVYAEVKRVGDT 539

  Fly   561 DRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLGYT---------PWMIELPLSGLMTIGFDIA 616
            ...:.||.|.:|..: |:.....:.:.:::|.|||..         |.:.:.|   ::.:|.|:.
  Rat   540 VLGMATQCVQMKNVQ-RTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQQP---VIFLGADVT 600

  Fly   617 --KSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSR 679
              .:...:|.:..|::.|||...| .|.:||........:...|..|:.:.|.|:....|..|:|
  Rat   601 HPPAGDGKKPSIAAVVGSMDAHPN-RYCATVRVQQHRQEIIQDLAAMVRELLIQFYKSTRFKPTR 664

  Fly   680 IVFYRDGVSSGSLKQLFEFEVKDIIE---KLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNGQNP 741
            |:|||||||.|..:|:...|:..|.|   ||:.:|      .|.:.:|||.:..:||.|...:|.
  Rat   665 IIFYRDGVSEGQFQQVLHHELLAIREACIKLEKDY------QPGITFIVVQKRHHTRLFCTDKNE 723

  Fly   742 --------PPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMC 798
                    |.||.||..||.|..:||||.|....|||..|:.|:||:.....|.:::|.|||::|
  Rat   724 RVGKSGNIPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLC 788

  Fly   799 HLYYNWSGTTRVPAVCQYAKKLA 821
            |.|...:.:..:||...||..:|
  Rat   789 HTYVRCTRSVSIPAPAYYAHLVA 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	38/136 (28%)
		PAZ	262..396	CDD:198017	23/141 (16%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	123/483 (25%)
Ago2	XP_038936150.1	PLN03202	7..859	CDD:215631	199/868 (23%)
Ago2	XP_038936150.1	Piwi_ago-like	393..818	CDD:240015	117/448 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910