Protein Alignment piwi and ago2

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_009292643.1
• Gene: ago2 / 570630
• ZFINID: ZDB-GENE-110606-6
• Length: 898
• Species: Danio rerio
• Alignment Length: 907
• Identity: 204/907 - (22%)
• Similarity: 359/907 - (39%)
• Gaps: 257/907 - (28%)

  Fly    83 PAELVSKK------GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSN---- 137
            |.|.|.|.      ||.|..:.||.|||.::. |:..:.||.::.:|.....||...::.:
Zfish    32 PQEYVFKPPQRPDFGTMGRTIKLQANFFEMEI-PKLEVYHYEIDIKPEKCPRRVNREIVEHMVQH 95

  Fly   138 -HANLLGSGY-LFDGLQ-LFTTR-------KFEQEITVLSGKSKLDIEYKISIKFVGFISCAE-- 190
             ...:.|... ::||.: |:|..       |.|.|:|: .|:.| |..:|::||::..:|...
Zfish    96 FKTQIFGDRKPVYDGRKNLYTAMPLPIGRDKVELEVTI-PGEGK-DRSFKVAIKWMSCVSLQALH 158

  Fly   191 -------PRF----LQVLNLILRRSMKGLNLELVGRNLFDP-----------RAKIEIREFKMEL 233
                   |..    :|.|::::|. :..:....|||:.|.|           |          |:
Zfish   159 EALSGRLPNIPFETIQALDVVMRH-LPSMRYTPVGRSFFTPSEGCSNPLGGGR----------EV 212

  Fly   234 WPGYETSIR-------------------------------------QHEKDIL------------ 249
            |.|:..|:|                                     :.:|.:.
Zfish   213 WFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEFMCEVLDFKSIEEQQKPLTDSQRVKFTKEIK 277

  Fly   250 -LGTEITH--KVMRTETIYDIMRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTP 311
             |..||||  ::.|...:.::.||    ||.||                   |:.:.. :.|||.
Zfish   278 GLKVEITHCGQMKRKYRVCNVTRR----PASHQ-------------------TFPLQQ-ENGQTI 318

  Fly   312 KSTFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCRVTGLNA 375
            :.|.:         :|:..||.:.:|..:.|         .|:....:....:| |:|.:.   |
Zfish   319 ECTVA---------QYFKDKYKLVLRYPHLP---------CLQVGQEQKHTYLPLEVCNIV---A 362

  Fly   376 EMRSNFQLM-RAMSSYTRMNPKQRTDR-------LRAFNHRLQNTPESVKVLRDWNMELDKNVTE 432
            ..|...:|. ...|:..|...:...||       :|:.|.   ||...|   |::.:.:..::||
Zfish   363 GQRCIKKLTDNQTSTMIRATARSAPDRQDEISKLMRSANF---NTDPYV---REFGVMVRDDMTE 421

  Fly   433 VQGRIIGQQNIVFHNGKV--PAGENADWQRH---------FRDQRMLTTPSDG------------ 474
            |.||:: |...:.:.|:|  .:.:.:.|...         |:: :.:.||..|
Zfish   422 VNGRVL-QAPSILYGGRVRISSAQLSIWLNPCLIWSCLWLFQN-KAIATPVQGVWDMRNKQFHTG 484

  Fly   475 --LDRWAV--IAPQRNSHE--LRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVR 533
              :..||:  .||||...|  |:...|.|.:.:...|:.|:....|.       .|.:..|..
Zfish   485 IEIKVWAIACFAPQRQCTELLLKAFTDQLRKISRDAGMPIQGQPCFC-------KYAQGADSV-- 540

  Fly   534 SDP------------KLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKI 586
             :|            :|::.::|. ....|:.:|:.|.....:.||.|.:|..:..:..:: :.:
Zfish   541 -EPMFKHLKYTYQGLQLVVVILPG-KTPVYAEVKRVGDTVLGMATQCVQVKNVQKTTPQTL-SNL 602

  Fly   587 AIQLNCKLGYT---------PWMIELPLSGLMTIGFDIA--KSTRDRKRAYGALIASMDLQQNST 640
            .:::|.|||..         |.:.:.|   ::.:|.|:.  .:...:|.:..|::.|||... |.
Zfish   603 CLKINVKLGGVNNILLPQGRPLVFQQP---VIFLGADVTHPPAGDGKKPSIAAVVGSMDAHP-SR 663

  Fly   641 YFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIE 705
            |.:||........:...|..|:.:.|.|:....|..|:||::||||:|.|...|:.:.|:..|.|
Zfish   664 YCATVRVQQHRQDIIQDLATMVRELLIQFYKSTRFKPTRIIYYRDGISEGQFNQVLQHELLAIRE 728

  Fly   706 ---KLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNGQNP--------PPGTIVDDVITLPERYDF 759
               ||:.:|      .|.:.::||.:..:||.|...:|.        |.||.||..||.|..:||
Zfish   729 ACIKLEKDY------QPGITFVVVQKRHHTRLFCMDRNERVGKSGNIPAGTTVDTKITHPFEFDF 787

  Fly   760 YLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLA 821
            ||.|....|||..|:.|:||:.....:.:::|.|||::||.|...:.:..:||...||..:|
Zfish   788 YLCSHAGIQGTSRPSHYHVLWDDNHFTSDELQVLTYQLCHTYVRCTRSVSIPAPAYYAHLVA 849

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	25/135 (19%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	126/511 (25%)
ago2	XP_009292643.1	ArgoN	106..180	CDD:465134	18/75 (24%)
		ArgoL1	190..240	CDD:462567	11/59 (19%)
		PAZ_argonaute_like	241..361	CDD:239212	27/161 (17%)
		Piwi_ago-like	406..856	CDD:240015	117/471 (25%)