Protein Alignment piwi and AGO3

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001036627.2
• Gene: AGO3 / 3355150
• FlyBaseID: FBgn0250816
• Length: 867
• Species: Drosophila melanogaster
• Alignment Length: 862
• Identity: 274/862 - (31%)
• Similarity: 445/862 - (51%)
• Gaps: 85/862 - (9%)

  Fly     6 GRGRRR---PLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPT 67
            ||||.|   .|..||.::::          |..|.|                 .|...::..||
  Fly    67 GRGRARLIDTLKTDDHTSNQ----------FITSES-----------------KENITKKTKGP- 103

  Fly    68 ERKPWGDQYDYLNTRPAELVSKK----------GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFE 122
                           .:|.::.:          |:.|..|.:..|:.:|.|.....:.:|.|.|.
  Fly   104 ---------------ESEAIASENGLFFPDLIYGSKGSSVNIYCNYLKLTTDESKGVFNYEVRFF 153

  Fly   123 PSIENPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISI---KFVG 184
            |.|::..:|:..|::|.:.||....|||..|:.......::||...|:: |:|.:|.|   |...
  Fly   154 PPIDSVHLRIKYLNDHKDKLGGTKTFDGNTLYLPILLPNKMTVFISKAE-DVELQIRILYKKKEE 217

  Fly   185 FISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDP-RAKIEIREFKMELWPGYETSIRQHEKDI 248
            ..:|.     |:.|::..|.||.||.....|..||| |.|| |...|:|:||||.|::.:::..:
  Fly   218 MRNCT-----QLYNILFDRVMKVLNYVKFDRKQFDPSRPKI-IPLAKLEVWPGYVTAVDEYKGGL 276

  Fly   249 LLGTEITHKVMRTETIYD-IMRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPK 312
            :|..:::|:::..:|:.: ::.....|...:|:..|..::..||||.||||||:|||:.|.|.|.
  Fly   277 MLCCDVSHRILCQKTVLEMLVDLYQQNVEHYQESARKMLVGNIVLTRYNNRTYKINDICFDQNPT 341

  Fly   313 STFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASEL-VVLIPELCRVTGLNAE 376
            ..|..|....|:||||...:||.|:|.||||:.|..:.:.:......| ..||||||.:|||..|
  Fly   342 CQFEIKTGCTSYVEYYKQYHNINIKDVNQPLIYSIKKSRGIPAERENLQFCLIPELCYLTGLRDE 406

  Fly   377 MRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQ 441
            :||:.:|||.::::||::|.||...|..|...:.|||.:.::|..|.:.|..|..::.||.:..:
  Fly   407 VRSDNKLMREIATFTRVSPNQRQMALNKFYENVSNTPAAQEILNSWGLSLTNNSNKISGRQMDIE 471

  Fly   442 NIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGL 506
            .|.|....|.||.:|::.:|.....||....  |.:|.:|..:.......:|||::.:|...:|:
  Fly   472 QIYFSKISVSAGRSAEFSKHAVTNEMLKVVH--LSKWIIIHLRNYRQAATSLLDNMKQACESLGM 534

  Fly   507 RIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTL 571
            .|.:|....:..||...|::|:...:..:.::::|:..|...:||::|||....:..:|:||:..
  Fly   535 NISNPTMISLDHDRIDAYIQALRRNITMNTQMVVCICHNRRDDRYAAIKKICCSEIPIPSQVINA 599

  Fly   572 KTTKN-RSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDL 635
            ||.:| ..:.|:..||.:|:|||||.:.|.:::|...:|..|.|......:|..:..|.:||::.
  Fly   600 KTLQNDLKIRSVVQKIVLQMNCKLGGSLWTVKIPFKNVMICGIDSYHDPSNRGNSVAAFVASINS 664

  Fly   636 QQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEV 700
            ..:..|...|.:....::: |.|......||:.|:..:.|||:.|:.||||:..|.|.....:|:
  Fly   665 SYSQWYSKAVVQTKREEIV-NGLSASFEIALKMYRKRNGKLPTNIIIYRDGIGDGQLYTCLNYEI 728

  Fly   701 KDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFF----LNGQNPPPGTIVDDVITLPERYDFYL 761
                    .::..|..:..:::||||.:.:|||.|    ::.:||.|||:||..||....|||:|
  Fly   729 --------PQFEMVCGNRIKISYIVVQKRINTRIFSGSGIHLENPLPGTVVDQHITKSNMYDFFL 785

  Fly   762 VSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGT 826
            |||.||||||:||.|.||.......|:.:|||:||:|.|||||:||.|:||.|.||.|||.|:|.
  Fly   786 VSQLVRQGTVTPTHYVVLRDDCNYGPDIIQKLSYKLCFLYYNWAGTVRIPACCMYAHKLAYLIGQ 850

  Fly   827 NLHSIPQNALEKKFYYL 843
            ::......||.:|.:||
  Fly   851 SIQRDVAEALSEKLFYL 867

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	54/135 (40%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	151/448 (34%)
AGO3	NP_001036627.2	PAZ	291..425	CDD:198017	54/133 (41%)
		Piwi_piwi-like_Euk	412..850	CDD:240016	151/448 (34%)