Protein Alignment piwi and Ago3

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001258122.1
• Gene: Ago3 / 313593
• RGDID: 1309163
• Length: 860
• Species: Rattus norvegicus
• Alignment Length: 882
• Identity: 202/882 - (22%)
• Similarity: 350/882 - (39%)
• Gaps: 218/882 - (24%)

  Fly    79 LNTRPAELVSKK---GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSN--- 137
            :..:|..:|.::   ||.|.|:.|..|.|:::. |:..:..|.|:.:|.....||...|:.:
  Rat     9 IGAQPLLIVPRRPGYGTMGKPIKLLANCFQVEI-PKIDVYLYEVDIKPDKCPRRVNREVVDSMVQ 72

  Fly   138 HANLLGSG---YLFDGLQ-LFT-------TRKFEQEITVLSGKSKLDIEYKISIKFVGFIS---- 187
            |..:...|   .::||.: |:|       |...:.::| |.|:...|..:|:|:|||..:|
  Rat    73 HFKVTIFGDRRPVYDGKRSLYTANPLPVATTGVDLDVT-LPGEGGKDRPFKVSVKFVSRVSWHLL 136

  Fly   188 --------CAEPRFL---------QVLNLILRRSMKGLNLELVGRNLFD-PRAKIEIREFKMELW 234
                    ..||..|         ..::::||. :..:....|||:.|. |...........|:|
  Rat   137 HEVLTGRTLPEPLELDKPISTNPVHAVDVVLRH-LPSMKYTPVGRSFFSAPEGYDHPLGGGREVW 200

  Fly   235 PGYETSIRQHEKDILLGTEI---------------------------------THKVMRTETIYD 266
            .|:..|:|.....::|..::                                 :|:|..|:.|..
  Rat   201 FGFHQSVRPAMWKMMLNIDVSATAFYKAQPVIQFMCEVLDIHNIDEQPRPLTDSHRVKFTKEIKG 265

  Fly   267 I---------MRR----C--SHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFS 316
            :         |||    |  :..||.||                   |:.: .::.|||.:.|.:
  Rat   266 LKVEVTHCGTMRRKYRVCNVTRRPASHQ-------------------TFPL-QLENGQTVERTVA 310

  Fly   317 CKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCRVTGLNAEMRSN 380
                     :|:..||.::::..:.|         .|:....:....:| |:|.:
  Rat   311 ---------QYFREKYTLQLKYPHLP---------CLQVGQEQKHTYLPLEVCNI---------- 347

  Fly   381 FQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESV-KVLRDWNMELDKNVTEVQGRIIGQQNIV 444
               :.......::...|.:..::|......:..|.: :::|..|.|.|..|.|.|.::  :..:.
  Rat   348 ---VAGQRCIKKLTDNQTSTMIKATARSAPDRQEEISRLVRSANYETDPFVQEFQFKV--RDEMA 407

  Fly   445 FHNGKV-PA------GENADWQRHFRDQRMLTTPSDG--------------LDRWAV--IAPQRN 486
            ...|:| ||      |.|          |.:.|||.|              :..||:  .|.||.
  Rat   408 HVTGRVLPAPMLQYGGRN----------RTVATPSHGVWDMRGKQFHTGVEIKMWAIACFATQRQ 462

  Fly   487 SHE--LRTLLDSLYRAASGMGLRIRSPQEFIIY---DDRTGTYVRAMDDCVRSDPKLILCLVPND 546
            ..|  |:...|.|.:.:...|:.|:....|..|   .|......|.:.: ..|..:||:.::|.
  Rat   463 CREEILKGFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFRHLKN-TYSGLQLIIVILPG- 525

  Fly   547 NAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCKLG---------YTPWMIE 602
            ....|:.:|:.|.....:.||.|.:|.....|..:: :.:.:::|.|||         ..|.:.:
  Rat   526 KTPVYAEVKRVGDTLLGMATQCVQVKNVIKTSPQTL-SNLCLKINVKLGGINNILVPHQRPSVFQ 589

  Fly   603 LPLSGLMTIGFDIA--KSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKA 665
            .|   ::.:|.|:.  .:...:|.:..|::.|||... |.|.:||........:...|..|:.:.
  Rat   590 QP---VIFLGADVTHPPAGDGKKPSIAAVVGSMDAHP-SRYCATVRVQRPRQEIIQDLASMVREL 650

  Fly   666 LRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIE---KLKTEYARVQLSPPQLAYIVVT 727
            |.|:....|..|:||:|||||||.|..:|:..:|:..|.|   .|:.:|      .|.:.||||.
  Rat   651 LIQFYKSTRFKPTRIIFYRDGVSEGQFRQVLYYELLAIREACISLEKDY------QPGITYIVVQ 709

  Fly   728 RSMNTRFFL--------NGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMG 784
            :..:||.|.        ...|.|.||.||..||.|..:||||.|....|||..|:.|:||:....
  Rat   710 KRHHTRLFCADRTERVGRSGNIPAGTTVDTDITHPYEFDFYLCSHAGIQGTSRPSHYHVLWDDNC 774

  Fly   785 LSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLA 821
            .:.:::|.|||::||.|...:.:..:||...||..:|
  Rat   775 FTADELQLLTYQLCHTYVRCTRSVSIPAPAYYAHLVA 811

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	22/149 (15%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	128/491 (26%)
Ago3	NP_001258122.1	ArgoN	73..167	CDD:465134	20/94 (21%)
		ArgoL1	177..227	CDD:462567	11/49 (22%)
		PAZ_argonaute_like	228..348	CDD:239212	25/170 (15%)
		Piwi_ago-like	393..818	CDD:240015	121/444 (27%)