DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment piwi and Ago4

DIOPT Version :9

Sequence 1:	NP_001285825.1	Gene:	piwi / 34521	FlyBaseID:	FBgn0004872	Length:	843	Species:	Drosophila melanogaster
Sequence 2:	XP_006238924.1	Gene:	Ago4 / 298533	RGDID:	1304583	Length:	861	Species:	Rattus norvegicus

Alignment Length:	910	Identity:	204/910 - (22%)
Similarity:	350/910 - (38%)	Gaps:	251/910 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 ALEEAPRREGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHV 119
            :|.:.|||.|                         .||.|.|:.|..|.|:::. |:..:.||.|
  Rat    11 SLFQPPRRPG-------------------------LGTVGKPIRLLANHFQVQI-PKIDVYHYDV 49

  Fly   120 EFEPSIENPRVRMGVLSN-----HANLLGS---GYLFDGLQ-LFTTR-------KFEQEITVLSG 168
            :.:|.....||...|:..     ...:.|.   ||  ||.: ::|..       :.:.|:| |.|
  Rat    50 DIKPEKRPRRVNREVVDTMVRHFKMQIFGDRQPGY--DGKRNMYTAHPLPIGRDRVDMEVT-LPG 111

  Fly   169 KSKLDIEYKISIKFV-------------GFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDP 220
            :.| |..:|:|:::|             |.:|......:|.|::|.|. :..:....|||:.|.|
  Rat   112 EGK-DQTFKVSVQWVSVVSLQLLLEALAGHLSEVPDDSVQALDVITRH-LPSMRYTPVGRSFFSP 174

  Fly   221 -----------RAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVM-RTETIYDIMRRCSH 273
                       |          |:|.|:..|:|.....::|..:::.... |.:.|.:.|  |
  Rat   175 PEGYYHPLGGGR----------EVWFGFHQSVRPAMWKMMLNIDVSATAFYRAQPIIEFM--C-- 225

  Fly   274 NPARHQDEVRVNVLDL-------IVLTDYN---------------------NRTYRINDVDFGQT 310
                       .|||:       ..|||..                     .|.||:.:|.....
  Rat   226 -----------EVLDIQNINEQTKPLTDSQRVKFTKEIRGLKVEVTHCGQMKRKYRVCNVTRRPA 279

  Fly   311 PKSTF-----SCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCR 369
            ...||     :.:..:.:..:|:..|||::::..:.|         .|:....:....:| |:|.
  Rat   280 SHQTFPLQLENGQAMECTVAQYFKQKYNLQLKYSHLP---------CLQVGQEQKHTYLPLEVCN 335

  Fly   370 VTG-------LNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELD 427
            :..       |.....|......|.|:..|   ::...||...|..| ..|:  ..|:::.:.:.
  Rat   336 IVAGQRCIKKLTDNQTSTMIKATARSAPDR---QEEISRLVKSNSVL-GGPD--PYLKEFGIVVH 394

  Fly   428 KNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDG--------------LDRW 478
            ..:||:.||::....:.:      .|.|          :.:.||:.|              :..|
  Rat   395 NEMTELMGRVLPAPMLQY------GGRN----------KTVATPNQGVWDMRGKQFYAGIEIKVW 443

  Fly   479 AV--IAPQRNSHE--LRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTG-----------TYVRAM 528
            ||  .|||:...|  |::..|.|.:.:...|:.|:....|..|.....           |||..
  Rat   444 AVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQPCFCKYAQGADSVEPMFKHLKMTYVGL- 507

  Fly   529 DDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATKIAIQLNCK 593
                    :||:.::|. ....|:.:|:.|.....:.||.|.:|.....|..:: :.:.:::|.|
  Rat   508 --------QLIVVILPG-KTPVYAEVKRVGDTLLGMATQCVQVKNVVKTSPQTL-SNLCLKINAK 562

  Fly   594 LG---------YTPWMIELPLSGLMTIGFDIA--KSTRDRKRAYGALIASMDLQQNSTYFSTV-T 646
            ||         ..|.:.:.|   ::.:|.|:.  .:...:|.:..|::.||| ...|.|.:|| .
  Rat   563 LGGINNVLVPHQRPSVFQQP---VIFLGADVTHPPAGDGKKPSIAAVVGSMD-GHPSRYCATVRV 623

  Fly   647 ECSAFDV---------LANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFE--- 699
            :.|..::         :...|..|..:.|.|:....|..|:||::||.|||.|.:||:...|
  Rat   624 QTSRQEIAQELLFSQEVVQDLTSMARELLIQFYKSTRFKPTRIIYYRGGVSEGQMKQVAWPELIA 688

  Fly   700 VKDIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFL--------NGQNPPPGTIVDDVITLPER 756
            ::.....|:.:|.      |.:.||||.:..:||.|.        ...|.|.||.||..||.|..
  Rat   689 IRKACISLEEDYR------PGITYIVVQKRHHTRLFCADKTERVGKSGNVPAGTTVDSTITHPSE 747

  Fly   757 YDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLA 821
            :||||.|....|||..|:.|.||:.....:.:::|.|||::||.|...:.:..:||...||:.:|
  Rat   748 FDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLTYQLCHTYVRCTRSVSIPAPAYYARLVA 812

Fly 822 821
Rat 813 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095	34/138 (25%)
		PAZ	262..396	CDD:198017	29/174 (17%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	124/501 (25%)
Ago4	XP_006238924.1	PLN03202	15..860	CDD:215631	203/906 (22%)
		ArgoN	18..155	CDD:293095	36/166 (22%)
		ArgoL1	167..216	CDD:285861	12/58 (21%)
		PAZ_argonaute_like	217..337	CDD:239212	24/143 (17%)
		Piwi_ago-like	384..819	CDD:240015	116/466 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910