Protein Alignment piwi and sago-1

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_504610.1
• Gene: sago-1 / 179016
• WormBaseID: WBGene00019666
• Length: 881
• Species: Caenorhabditis elegans
• Alignment Length: 873
• Identity: 171/873 - (19%)
• Similarity: 319/873 - (36%)
• Gaps: 228/873 - (26%)

  Fly    17 DSSTSRGSG-DGPR-----VKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPTERKPWGDQ 75
            :.|.|.||| |..|     ::|:|             :|:::.:.|     :.|||......|..
 Worm    83 EKSKSVGSGCDHERSKSHCLRVYR-------------KAAKQCQEL-----KSGGPFCYDSQGCL 129

  Fly    76 YDYLNTRPAELVSK-KGTD--GVPVMLQTNFFRLKTKPEWRI----VHYHVEFEPSIENPRVRMG 133
            |.:...:..|..:. .|:|  ..|..|:..|...|.:..::.    |...|...|:::...:...
 Worm   130 YSFSKLKNDEFSTNITGSDISNNPKFLRVEFKLAKVQESFQTTTNDVAKSVNCRPALQEKTILEA 194

  Fly   134 ---VLS----NHANLLGSG----YLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKI--SIKFVGF 185
               ::|    ||.|:|..|    ||:|...:..     :.||...|||......|.  :::..|.
 Worm   195 MNQIVSTAPINHPNVLTIGNCVHYLYDDTNIDI-----RSITGEGGKSSAVGASKSVRTLEGTGK 254

  Fly   186 ISCAEPRFLQVLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQH------ 244
            ..|          |.:...:|        ..||.|.....::.| |: :.|:..|::.:
 Worm   255 TPC----------LYMATELK--------TTLFHPDNCSLLKVF-MD-YRGFNGSLKANSPFVLK 299

  Fly   245 EKDILLGTEITHKVMRTETIYDIMRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQ 309
            .|:..:|.          ..|....:||                     |:.:....|...|||.
 Worm   300 NKNAFIGL----------WCYTTHGKCS---------------------DWKDDRPMIKIKDFGL 333

  Fly   310 TPK-STFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGL 373
            :.| :||....:.||...|:..|||:.::..:...::::.:|    .....:.|...:||....:
 Worm   334 SAKETTFERDNKKISVFNYFQVKYNMTLKYPDLFTVVARGKD----GKNQHIPVECLDLCNSQTV 394

  Fly   374 NAEM-----RSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTE- 432
            ..|.     :::...:.|...:.|   |:.||.: ..:..|.:.|:.:         :.....|
 Worm   395 RTEQMVGTEQADLIKLAAAKPHDR---KKITDTV-VNSIGLASEPKGI---------ISVGAPES 446

  Fly   433 VQGRIIGQQNIVFHNGK----------------VPAGENADWQRHFRDQRMLTTPSDGLDRWAVI 481
            |.|.::.:.:|.|..||                :|||             ....|:. |..|.|:
 Worm   447 VTGLVLPKPDIYFSGGKKVFWNDPKKRGPATDFMPAG-------------TFIKPTK-LTNWEVV 497

  Fly   482 APQRNSHELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAM-DDCVRSDPKLILCLVPN 545
            ..  |..:|...:..|......:|:.:.:|...:|    ...|:|:: ::...::.:||:.:..:
 Worm   498 FD--NGVQLVDCIQHLTSTMRQLGMEVSNPTVSLI----NRGYLRSIFENAKAANRQLIMFITKS 556

  Fly   546 DNAERYSSIKKRGYVDRAVPTQVVTLKT-TKNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGL- 608
            .|  .|.:..|....:..:.||.:..:| .|.....:....|..:.|.|||...:.:.   ||:
 Worm   557 MN--NYHTEIKCLEQEFDLLTQDIRFETAVKLAQQQNTRKNIIYKTNMKLGGLNYELR---SGVF 616

  Fly   609 -----MTIGFDIAKSTRDRKRAYGALIA---SMDLQQNSTYFS---TVTECSAFD---VLANTLW 659
                 :.|||:    |..|.....|.||   :.::..:|..|:   ...:.||.:   |:...|.
 Worm   617 SNSKRLIIGFE----TSQRGGLGDAPIAIGFAANMMSHSQQFAGGYMFVKKSADNYGPVIPEILL 677

  Fly   660 PMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYARVQLSP------ 718
            .::.:|.....::.   |..::.|..|||.|.             ..|..||...|:..
 Worm   678 TILKQAKANRPNDR---PDELLIYFSGVSEGQ-------------HALVNEYYANQVKAACGLFN 726

  Fly   719 ----PQLAYIVVTRSMNTRFFL--NGQ---NPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPT 774
                |.:..|:.::..|||.:.  ||.   |..|||::|..|..|...::|......||||....
 Worm   727 ESFRPHITLILASKVHNTRVYKSENGGGVCNVEPGTVIDHTIVSPVLSEWYHAGSLARQGTSKLV 791

  Fly   775 SYNVLYSSMGLSPEKM---QKLTYKMCH 799
            .|::::::.  ..||:   ::||.::|:
 Worm   792 KYSLIFNTK--KNEKLSVYERLTNELCY 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	24/139 (17%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	95/470 (20%)
sago-1	NP_504610.1	PAZ	281..412	CDD:198017	27/166 (16%)
		Piwi-like	443..844	CDD:239208	88/422 (21%)