Protein Alignment piwi and wago-10

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_503177.1
• Gene: wago-10 / 178560
• WormBaseID: WBGene00020707
• Length: 990
• Species: Caenorhabditis elegans
• Alignment Length: 939
• Identity: 198/939 - (21%)
• Similarity: 338/939 - (35%)
• Gaps: 255/939 - (27%)

  Fly    51 RERRALE---EAPRREGGP---TERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTK 109
            |.||:.|   .|.:|...|   :...|..|.:..:.||..:|               |.|.|...
 Worm    24 RTRRSSEVDVPATKRPAPPLTSSTSLPTRDSFSIIETRDVQL---------------NMFALNIS 73

  Fly   110 --PEWRIVHYHVEFEPSIENPR---VRMGVLSN-------------HA----------NLLGSG- 145
              |. :|..:||:.....:|.:   |..|||:|             ||          .|.|..
 Worm    74 GMPR-KIQRFHVDTLIKGKNGKIFNVNHGVLANSGDINSHNKRLAQHALMQKFHKKRRELFGQHD 137

  Fly   146 ------------YLFDGLQL--------FTTRKFEQEITVLSGK--SKLDIEYKISIKFVGFISC 188
                        ||.||:.|        |.:..|..|...::.|  .|.|..|.:.|:..|||..
 Worm   138 YHILAYDCANTLYLPDGVYLGRNEEECTFKSDDFSPEQWNITSKLSRKKDYTYVMKIRPSGFIYT 202

  Fly   189 AEPRFLQVLN---------LILRRSMKGLNLELVGRNLFDPRAK--------------------- 223
            :.....:|.|         ::..:.:...:....|.:.|..||:
 Worm   203 SGEEASEVANRMELTRCVEIVTSQKLNNSDYCQFGNDTFSFRAQPVSEPDATSEIRSGFAKVSRI 267

  Fly   224 IEIREFKMELWPGYETSIRQHEKDILLGTEITHKVM--RTETIYDIMRRCSHNPAR--------- 277
            :|.|..|.|:....:|......|...:...:..|.:  |..:..|...|..:|..:
 Worm   268 VEGRNGKNEMLMAIDTKASPFYKSTSVLNFVCGKYLEKRGSSRNDYRGRGDYNRKKTGGGSTDAP 332

  Fly   278 -HQDEVRV----------------------------NVLDLIVLTDYNNRTYRINDVDFGQTPKS 313
             |||...|                            |..:||:::       |:.:.: .:|.|.
 Worm   333 DHQDVAEVERSLEYRENRQQIEEALKGLLVSAAHLKNSTNLIMIS-------RVAETN-SETTKF 389

  Fly   314 TFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKN-RDKALKTNASELVVLIPELCRVTGLNAEM 377
            ..:...|:||..::||..||.|::....||::||. ||:..  ...||:.:.|.. |:.  :.:|
 Worm   390 MTNNGEREISVADHYLEAYNYRLKYPKMPLVVSKRFRDECF--YPMELLQVAPGQ-RIK--DHKM 449

  Fly   378 RSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKN------------- 429
            .:..|:  ||.......|::..|.::   |.|..           |::||:|
 Worm   450 SAAVQM--AMKGQKSTLPQKHVDLVK---HVLSR-----------NLKLDRNLYMDAFGIKLESA 498

  Fly   430 -VTEVQGRIIGQQNIVFHNG-KVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQR--NSHEL 490
             :.::|.:|:....|.|.:. .:|...|.    .||.......|:| ::..|::...|  :..:.
 Worm   499 ELVKLQSKILPPPQIKFKDEVYMPKMGNP----VFRTNGRFVDPAD-INAVAIVVFDRAIDMRQA 558

  Fly   491 RTLLD--SLYRAASGMGLRIRSPQEFIIYDDRTGTYV---RAMDDCVRSDPKLILCLVPNDNAER 550
            ....|  |.|...:|:.:: :|.:::.|.:..:...|   .||:........:::.:......:.
 Worm   559 ENFCDRLSCYCRENGITVK-KSSRDWPIREINSEDSVAIKNAMEKWFSKGVNILVAIAKEKKPDV 622

  Fly   551 YSSIKKRGYVDRAVPTQVVTL-KTTKNRSLMS----IATKIAIQLNCKLGYTPWMIELPLS---- 606
            :..:|   |.:.:|..|.:.: |.|.:..|.|    .|..:..:.|.|.|.|.:.:::|.|
 Worm   623 HDVLK---YYEASVGLQTIQVCKQTVDMMLSSGGRQTADNVMRKFNLKCGGTNFFVQIPRSVNGR 684

  Fly   607 ---------------GLMTIGFDIAKSTRDR--KRAYGALIASMDLQQNSTYFSTVTECSAF--- 651
                           .:..|||||:......  .|:.|.:...:.:...|...|..|....|
 Worm   685 TVCADAHLLNEKLFERVQFIGFDISHGASRTLFDRSTGKMDGEVSIVGVSYSLSHSTHLGGFAYM 749

  Fly   652 ----DVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKTEYA 712
                :.....|..:..|.:..|::...:|||:||.||.|...|..|:     ||:.::|::..:.
 Worm   750 QTQKEYKLQKLDEVFPKCVDSYRNHTGRLPSKIVIYRIGAGEGDFKR-----VKEEVDKIRGTFN 809

  Fly   713 RVQLSP---PQLAYIVVTRSMNTRFF---LNG-----QNPPPGTIVDDVITLPERYDFYLVSQQV 766
            |:|  |   |||..|:..|..:.|.|   :.|     ||...||.||.|||.....:|.|.||..
 Worm   810 RIQ--PDYRPQLVVIIAQRDSHVRVFPAHITGSKAGQQNVTSGTCVDSVITSLGHQEFILSSQMP 872

  Fly   767 RQGTVSPTSYNVLYSSMGLSPEKMQKLTY 795
            ..|||.|..|.:|.:....:..::..|||
 Worm   873 LLGTVRPCKYTILTNDPNWTKTEITHLTY 901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	35/172 (20%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	107/480 (22%)
wago-10	NP_503177.1	PAZ_argonaute_like	347..439	CDD:239212	22/101 (22%)
		ArgoL2	<478..515	CDD:465136	7/47 (15%)
		Piwi-like	499..932	CDD:239208	96/419 (23%)