Protein Alignment piwi and csr-1

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001040938.1
• Gene: csr-1 / 177591
• WormBaseID: WBGene00017641
• Length: 1030
• Species: Caenorhabditis elegans
• Alignment Length: 1029
• Identity: 196/1029 - (19%)
• Similarity: 353/1029 - (34%)
• Gaps: 329/1029 - (31%)

  Fly     6 GRG---RRRPLNEDDSST--------SRGSGDGPRVKVFRGSSSG------------DPR----- 42
            |||   |||   :|:.|.        :||:..|.    :||.:.|            ||:
 Worm    91 GRGGYDRRR---DDEESKAENRFGGYNRGANGGN----YRGRTGGSGRGGSTQTTTVDPKYNGLI 148

  Fly    43 ----ADPRIEASRERRALEEAPR------------------------------------------ 61
                |:|:::........::.||
 Worm   149 LENSAEPKLKGLNSDMNQKQNPRLALNIFGLELSERTIFRHVVQMKLIDRQHNKEYILTTMSARG 213

  Fly    62 REGGPTERKPWGDQYDYLNTRPAELVSKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIE 126
            |....|::|   |.:..|:....:..:|||...:|.........|.|. |...:...::.|.::|
 Worm   214 RGNRATKQK---DNFILLDILLKQWAAKKGQQNLPAFAYDGAQSLFTL-EGISLMVDIKKEDALE 274

  Fly   127 NPRVRMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISC--- 188
            .|.:             |.:|.|            .|:.|||  .|:|..:..::...|:..
 Worm   275 IPEL-------------SNFLKD------------SISFLSG--DLEISCEPDLEKPSFVQTELN 312

  Fly   189 --AEPRFLQVLNLILRRS----------MKGL-----NLE------------------LVGRN-- 216
              ::|||...|:::..:|          .|||     :||                  :||.|
 Worm   313 EWSDPRFYAYLDIVTSQSAIRSERYLSQSKGLYVHTQSLEELRVKWAVAAKGIHKGCRIVGANGP 377

  Fly   217 ----LFDPR-----AKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVMRTETIYDIMRRCS 272
                ..||:     |.|.:.:.....:|      |....:.::...:  |:.|...:  :::...
 Worm   378 LPILELDPQSTQYYASIPLSQMLQYAFP------RDFPPNRIVNPNM--KLQRAVKL--LLKDLK 432

  Fly   273 HNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCKGRDISFVEYYLTKYNIRIR 337
            .||  :.|:.::          :...|..::|||:.......|..|..::.|
 Worm   433 CNP--YYDDKQI----------WATNTITVSDVDYNAPKDPEFRQKYPNLKF------------- 472

  Fly   338 DHNQPLLISKNRDKALKTNASELVVLIP-ELCRV---TGLNAEMRSNFQLM-RAMSSYTRMNPKQ 397
                |:|      .|::........|:| |..:|   ..::..:...|:|. ||.:...|.:..|
 Worm   473 ----PML------PAVQCGTGPHKRLMPLEYLKVLPYQSIDRRVLEEFELTPRANAPNERWSTLQ 527

  Fly   398 RTDRLRAFNHRLQNTPESVKVLRDWNMEL----DKNVTEVQGRIIGQQNIVFHNGKVPAGENADW 458
            :......||.         :|::|:.:::    ..||:|:.|..:...::.:.:......|..||
 Worm   528 KHYDQFGFND---------QVMKDFGVQICNDPFNNVSEIDGERVLAPSVAYADPVHVDDEKRDW 583

  Fly   459 QRHFRDQRMLTTPSDGLDRWAVIAPQRNSHE-----LRTLLDSLYRAASGMGLRI---------- 508
            :.  :|::.:|..:.....:.::|....:.:     .:.:..:..:.....|:.|
 Worm   584 KA--QDKKFVTPATIDHLMFVLVAGYTRTWDADCDATKFVAKAFMQRCKDKGMHIGSYSMDQHNG 646

  Fly   509 -RSPQEFII-----------YDDRTGT-YVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYV 560
             |..:.|:.           |.|.:.| :|..:.|.|   |.:..||   ...||.|.|
 Worm   647 ERGSENFLTSVFKNLVTHPNYRDSSFTPFVLFISDDV---PNIHECL---KFEERMSDI------ 699

  Fly   561 DRAVPTQVVTLKTTK-------------NRSLMSIATKIAIQLNCKLGYTPWMIELPLS------ 606
                |||.|.||..|             .|:.......|.::.|.|.|...:..::|..
 Worm   700 ----PTQHVLLKNVKKMRDNIEKKSQGGRRAYDLTLDNIVMKANIKCGGLNYTADIPRDLACWNE 760

  Fly   607 -GLMTIGFDIAKSTRDRKRAYGALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAK-----A 665
             ....||.|:|...|:..|........:........:|.:.:....|.....:...|.:     :
 Worm   761 VSTFVIGMDVAHPDRNAAREGNPSTVGLSCNSAENPYSFIGDFLYTDPRREAIQDEILRKFTDQS 825

  Fly   666 LRQYQHEHRKLPSRIVFYRDGVSSG----SLKQLFEFEVKDIIEKLKT--------EYARVQLSP 718
            :|.:. |.|..|.:::.:|||||.|    :||     ||:.|.:.:||        :||
 Worm   826 VRNFA-EIRGFPKKVIIFRDGVSFGEETAALK-----EVEIIEQTIKTAAKSMGHSDYA------ 878

  Fly   719 PQLAYIVVTRSMNTRFFLNGQ-------NPPPGTIV-DDVITLPERYDFYLVSQQVRQGTVSPTS 775
            |::..|||.:..:|||:..|.       ||.|.|.| .|:....:|..|....:.| |||....|
 Worm   879 PKVLAIVVKKRHHTRFYAKGGHHGNMPINPLPDTSVGGDIAEYGKRQIFIQAFRPV-QGTAKVPS 942

  Fly   776 YNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLH 829
            :.|:.....:|.|.:.|:...:|.|:...:..|.:|.....|.:||.. ||.|:
 Worm   943 FLVIRDDEEVSDEHVAKMVCAVCSLHQLVNSPTSIPTPVYVAHELAKR-GTGLY 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	22/138 (16%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	109/521 (21%)
csr-1	NP_001040938.1	PAZ_argonaute_like	361..497	CDD:239212	27/180 (15%)
		Piwi-like	555..993	CDD:239208	100/469 (21%)