Protein Alignment piwi and alg-4

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_499191.1
• Gene: alg-4 / 176400
• WormBaseID: WBGene00006449
• Length: 1040
• Species: Caenorhabditis elegans
• Alignment Length: 1042
• Identity: 213/1042 - (20%)
• Similarity: 378/1042 - (36%)
• Gaps: 313/1042 - (30%)

  Fly     9 RRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGGPTERKPWG 73
            ||...:..|::|...||       ..||.|..|....|..:.      :.:|....|......:.
 Worm     3 RRNATSFVDNNTLTSSG-------ISGSGSMSPPITSRPASG------QASPLTSNGSLSPPQYA 54

  Fly    74 D-----QYDY----------------LNTRPAELVSKK--GTDGVPVMLQTNFFRLKTK-PEWRI 114
            |     .|:.                ||.|  |:|::.  ||.|..:.:::|||.:..| |:..:
 Worm    55 DDQGSVSYNLDSPRDLSPLLLSELACLNMR--EVVARPGLGTIGRQIPVKSNFFAMDLKNPKMVV 117

  Fly   115 VHYHVEFEPSIENPRVR------MGVL-----SNHANLLGSGY--LFDGL-QLFTTRKFEQEITV 165
            :.||||    |.:|..|      |.::     |:|.|:..:.:  .:||. ||:|..:.  |...
 Worm   118 IQYHVE----IHHPGCRKLDKDEMRIIFWKAVSDHPNIFHNKFALAYDGAHQLYTVARL--EFPD 176

  Fly   166 LSGKSKLDIEYK------------ISIKFVGFISCAEPRF------------LQVLNLILRRSM- 205
            ..|..:||.|..            |||:.||.:.....|.            :|:|::|.|:|:
 Worm   177 DQGSVRLDCEASLPKDNRDRTRCAISIQNVGPVLLEMQRTRTNNLDERVLTPIQILDIICRQSLT 241

  Fly   206 -----------------------KGLNLELVGRNLFDPRAKIEIREFKMELWPGYETS--IRQHE 245
                                   .|..|:|.|..               |:|.|:.:|  |..:.
 Worm   242 CPLLKNSANFYTWKSSCYRIPTAAGQALDLEGGK---------------EMWTGFFSSAHIASNY 291

  Fly   246 KDILLGTEITH------KVMRTETIYDIMRRCSHNPARH-------------------------- 278
            :. ||..::.|      ::...:.:.|::...:..|.|:
 Worm   292 RP-LLNIDVAHTAFYKTRITVLQFMCDVLNERTSKPNRNNPRGPGGPGGPGGYRGGRGGGRGGSY 355

  Fly   279 -------------QDEVRVNVLDLIV--------LTDYNN---------------------RTYR 301
                         :|:...|.|...:        |:.:..                     |.|:
 Worm   356 GNFGNRGPPGANVRDDFGGNGLTFTMDTLSRDTQLSSFETRIFGDAIRGMKIRAAHRPNAIRVYK 420

  Fly   302 INDVDFGQTPKSTFSCKGRD-------ISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASE 359
            :|.:   |.|......:|.|       .|..:|:..||.        ||...|.  ..|......
 Worm   421 VNSL---QLPADKLMFQGIDEEGRQVVCSVADYFSEKYG--------PLKYPKL--PCLHVGPPT 472

  Fly   360 LVVLIP-ELCRVTGLNAEMRSNFQLMRAMSS----YTRMNPKQRTDRLRAFNHRLQNTPESVKVL 419
            ..:.:| |.|.:   ::..:.|.::....:|    ...::..||.||::..  ..|.:..:...|
 Worm   473 RNIFLPMEHCLI---DSPQKYNKKMSEKQTSAIIKAAAVDATQREDRIKQL--AAQASFGTDPFL 532

  Fly   420 RDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDG---LDRWAVI 481
            :::.:.:...:.:...|:|....|:|      .|.|       |....:..|.||   :|...:.
 Worm   533 KEFGVAVSSQMIQTTARVIQPPPIMF------GGNN-------RSVNPVVFPKDGSWTMDNQTLY 584

  Fly   482 AP-------------QRNSHELRTLLDSLYRAASGMGLRIRSPQEFIIY----DDRTGTYVRAMD 529
            .|             .|:...|:|...||...|:.||:......:.:.|    :|....:....|
 Worm   585 MPATCRSYSMIALVDPRDQTSLQTFCQSLTMKATAMGMNFPRWPDLVKYGRSKEDVCTLFTEIAD 649

  Fly   530 ---------DCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKTTKNRSLMSIATK 585
                     ||       |:.::.:.|::.|.::|::..:...:.:|.|.:|.. :|...:....
 Worm   650 EYRVTNTVCDC-------IIVVLQSKNSDIYMTVKEQSDIVHGIMSQCVLMKNV-SRPTPATCAN 706

  Fly   586 IAIQLNCKLG-----------YTPWMIELPLSGLMTIGFDIAKSTRDRKR----AYGALIASMDL 635
            |.::||.|:|           ...::::.|   .|.:|.|:...|:...|    :..|::|::||
 Worm   707 IVLKLNMKMGGINSRIVADKITNKYLVDQP---TMVVGIDVTHPTQAEMRMNMPSVAAIVANVDL 768

  Fly   636 QQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEV 700
            ...|...:...:....:.:...|..:..:.:..|:|..:| |:||:.||||||.|...::    :
 Worm   769 LPQSYGANVKVQKKCRESVVYLLDAIRERIITFYRHTKQK-PARIIVYRDGVSEGQFSEV----L 828

  Fly   701 KDIIEKLKTEYARV--QLSPPQLAYIVVTRSMNTRFFLNGQNP--------PPGTIVDDVITLPE 755
            ::.|:.::|....:  ...|| :.||||.:..:.|.|...||.        ||||.||..|..||
 Worm   829 REEIQSIRTACLAIAEDFRPP-ITYIVVQKRHHARIFCKYQNDMVGKAKNVPPGTTVDTGIVSPE 892

  Fly   756 RYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKL 820
            .:||||.|....|||..|..|:||......:.:::|.:||.|||.|...:.:..:|....||..:
 Worm   893 GFDFYLCSHYGVQGTSRPARYHVLLDECKFTADEIQSITYGMCHTYGRCTRSVSIPTPVYYADLV 957

  Fly   821 AT 822
            ||
 Worm   958 AT 959

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	27/213 (13%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	115/499 (23%)
alg-4	NP_499191.1	ArgoN	154..235	CDD:465134	18/82 (22%)
		ArgoL1	262..306	CDD:462567	12/59 (20%)
		PAZ_argonaute_like	374..484	CDD:239212	21/122 (17%)
		Piwi_ago-like	530..964	CDD:240015	109/460 (24%)