Protein Alignment piwi and hrde-1

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_497834.1
• Gene: hrde-1 / 175535
• WormBaseID: WBGene00007624
• Length: 1032
• Species: Caenorhabditis elegans
• Alignment Length: 656
• Identity: 149/656 - (22%)
• Similarity: 252/656 - (38%)
• Gaps: 157/656 - (23%)

  Fly   269 RRCSHNPARHQD----EVRVNVLDLIVLTDYN--NRTYRINDVDFGQTPKSTFSCKGRDISFVEY 327
            :||.....:..|    .::.|::.:..:.:.|  |.::.:.| |.|:          |:::..||
 Worm   391 KRCIEEALKGLDVECTHLKGNLIRVSSIAENNAENTSFMMKD-DKGE----------REVTVAEY 444

  Fly   328 YLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCRV-----------TGLNAEMRSN 380
            :|.:|||:::....||::|| |.|.......||:.:.| :..:|           ||.||.|..:
 Worm   445 FLLQYNIKLKYPRLPLVVSK-RFKHESFFPMELLRIAPGQRIKVNKMSPTVQSAMTGRNASMPQH 508

  Fly   381 FQLMRAMSSYTRMNPK-QRTDRLRAFNHRLQNT-----------PESVK---------VLRDWNM 424
            .  ::.:....|.|.| ::...:.||..:|.:|           |..:|         :.|....
 Worm   509 H--VKLVQDILRDNLKLEQNKYMDAFGIKLMSTEPIQMTAKLLPPAQIKFKGQTYMPDMSRPAFR 571

  Fly   425 ELDKNVTEVQGRIIGQQNIVFHN--GKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNS 487
            ..||.|...:.|.||  .:||.|  ....|.:..|...:|.....:|...|..| |::  .:.||
 Worm   572 TQDKFVEPARIRKIG--IVVFDNCIQMRQAEDFCDKLSNFCRDNGITVEKDSRD-WSI--RELNS 631

  Fly   488 HELRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYS 552
            .: ...:.:|.:                          :.:||  |.|   ||..:..:......
 Worm   632 SD-SVAIQNLMK--------------------------KWLDD--RVD---ILVGIAREKKPDVH 664

  Fly   553 SIKKRGYVDRAVPTQVVTL------KTTKNRSLMSIATKIAIQLNCKLGYTPWMIELP------- 604
            .|.|  |.:.::..|.:.|      |....:........:..:.|.|.|.|.:.:|:|
 Worm   665 DILK--YFEESIGLQTIQLCQQTVDKMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKA 727

  Fly   605 ------------LSGLMTIGFDI----AKSTRDRKRAY-----GALIASMDLQQNS-----TYFS 643
                        |..:..|||:|    :::..||.|:.     ..:..|..|..::     ||..
 Worm   728 VCSNNETLRKKLLEHVQFIGFEISHGASRTLFDRSRSQMDGEPSVVGVSYSLTNSTQLGGFTYLQ 792

  Fly   644 TVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLK 708
            |..|..     ...|.....|.:|.|:...:.||:|||.||.|...|:..:     ||:.:|:::
 Worm   793 TQKEYK-----LQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGNFNR-----VKEEVEEMR 847

  Fly   709 TEYARVQLSP---PQLAYIVVTRSMNTRFF---LNG-----QNPPPGTIVDDVITLPERYDFYLV 762
            ..:.::|  |   |.|..|:..|:.:.|.|   ::|     ||.|.||.|::|:|.....:|.|.
 Worm   848 RTFDKIQ--PGYRPHLVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILS 910

  Fly   763 SQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTN 827
            ||....|||.|..|.:|.:....|..::..|||.....:........||.|...|:.||.. |.|
 Worm   911 SQTPLIGTVRPCKYTILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKR-GRN 974

  Fly   828 LHSIPQ 833
            .:.|.|
 Worm   975 NYKIHQ 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	33/144 (23%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	114/516 (22%)
hrde-1	NP_497834.1	PAZ_argonaute_like	389..480	CDD:239212	24/100 (24%)
		Piwi-like	540..974	CDD:239208	108/485 (22%)