Protein Alignment piwi and hrde-1

DIOPT Version :9

• Sequence 1: NP_001285825.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_497834.1
• Gene: hrde-1 / 175535
• WormBaseID: WBGene00007624
• Length: 1032
• Species: Caenorhabditis elegans
• Alignment Length: 655
• Identity: 147/655 - (22%)
• Similarity: 246/655 - (37%)
• Gaps: 155/655 - (23%)

  Fly   269 RRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTFSCKG----RDISFVEYYL 329
            :||.....:..|         :..|.......|::.:.......::|..|.    |:::..||:|
 Worm   391 KRCIEEALKGLD---------VECTHLKGNLIRVSSIAENNAENTSFMMKDDKGEREVTVAEYFL 446

  Fly   330 TKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIP-ELCRV-----------TGLNAEMRSNFQ 382
            .:|||:::....||::|| |.|.......||:.:.| :..:|           ||.||.|..:.
 Worm   447 LQYNIKLKYPRLPLVVSK-RFKHESFFPMELLRIAPGQRIKVNKMSPTVQSAMTGRNASMPQHH- 509

  Fly   383 LMRAMSSYTRMNPK-QRTDRLRAFNHRLQNT-----------PESVK---------VLRDWNMEL 426
             ::.:....|.|.| ::...:.||..:|.:|           |..:|         :.|......
 Worm   510 -VKLVQDILRDNLKLEQNKYMDAFGIKLMSTEPIQMTAKLLPPAQIKFKGQTYMPDMSRPAFRTQ 573

  Fly   427 DKNVTEVQGRIIGQQNIVFHN--GKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHE 489
            ||.|...:.|.||  .:||.|  ....|.:..|...:|.....:|...|..| |::  .:.||.:
 Worm   574 DKFVEPARIRKIG--IVVFDNCIQMRQAEDFCDKLSNFCRDNGITVEKDSRD-WSI--RELNSSD 633

  Fly   490 LRTLLDSLYRAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSI 554
             ...:.:|.:                          :.:||  |.|   ||..:..:.......|
 Worm   634 -SVAIQNLMK--------------------------KWLDD--RVD---ILVGIAREKKPDVHDI 666

  Fly   555 KKRGYVDRAVPTQVVTL------KTTKNRSLMSIATKIAIQLNCKLGYTPWMIELP--------- 604
            .|  |.:.::..|.:.|      |....:........:..:.|.|.|.|.:.:|:|
 Worm   667 LK--YFEESIGLQTIQLCQQTVDKMMGGQGGRQTIDNVMRKFNLKCGGTNFFVEIPNAVRGKAVC 729

  Fly   605 ----------LSGLMTIGFDI----AKSTRDRKRAYGALIASMDLQQN----STYFSTVTECSAF 651
                      |..:..|||:|    :::..||.|      :.||.:.:    |...:..|:...|
 Worm   730 SNNETLRKKLLEHVQFIGFEISHGASRTLFDRSR------SQMDGEPSVVGVSYSLTNSTQLGGF 788

  Fly   652 DVL-------ANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDIIEKLKT 709
            ..|       ...|.....|.:|.|:...:.||:|||.||.|...|:..:     ||:.:|:::.
 Worm   789 TYLQTQKEYKLQKLDEFFPKCVRSYKEHSKTLPTRIVIYRVGAGEGNFNR-----VKEEVEEMRR 848

  Fly   710 EYARVQLSP---PQLAYIVVTRSMNTRFF---LNG-----QNPPPGTIVDDVITLPERYDFYLVS 763
            .:.::|  |   |.|..|:..|:.:.|.|   ::|     ||.|.||.|::|:|.....:|.|.|
 Worm   849 TFDKIQ--PGYRPHLVVIIAQRASHARVFPSCISGNRATDQNIPSGTCVENVLTSYGYDEFILSS 911

  Fly   764 QQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTNL 828
            |....|||.|..|.:|.:....|..::..|||.....:........||.|...|:.||.. |.|.
 Worm   912 QTPLIGTVRPCKYTILVNDAKWSKNELMHLTYFRAFGHQVSYQPPSVPDVLYAAENLAKR-GRNN 975

  Fly   829 HSIPQ 833
            :.|.|
 Worm   976 YKIHQ 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_001285825.1	ArgoN	91..201	CDD:293095
		PAZ	262..396	CDD:198017	31/142 (22%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	114/517 (22%)
hrde-1	NP_497834.1	DUF1777	315..>379	CDD:285811
		PAZ_argonaute_like	389..480	CDD:239212	22/98 (22%)
		ArgoL2	517..556	CDD:293097	8/38 (21%)
		Piwi-like	540..974	CDD:239208	108/486 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910