Protein Alignment piwi and prg-1

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_492121.1
• Gene: prg-1 / 172515
• WormBaseID: WBGene00004178
• Length: 824
• Species: Caenorhabditis elegans
• Alignment Length: 892
• Identity: 268/892 - (30%)
• Similarity: 437/892 - (48%)
• Gaps: 117/892 - (13%)

  Fly     1 MADDQGRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRADPRIEASRERRALEEAPRREGG 65
            ||...||||           .||||         .::||
 Worm     1 MASGSGRGR-----------GRGSG---------SNNSG-------------------------- 19

  Fly    66 PTERKPWGDQYDYLNTRPAELV------SKKGTDGVPVMLQTNFFRLK-TKPEWRIVHYHVEFEP 123
                   |....||.|...:|.      ||.|:.|.|.....||..:: |:.::.|..|||||||
 Worm    20 -------GKDQKYLGTIQPDLFIRQQGQSKTGSSGQPQKCFANFIPIEMTQSDYSIYQYHVEFEP 77

  Fly   124 SIENPRVRMGVL--SNHANLLGSGYLFDGLQLFTTRKFEQ----EITVLSGKSKLDIEYKISIKF 182
            ::::...|..:|  :|..:.:|..::|||:.|:...::||    |:.....:|.:.|.:|.:.:|
 Worm    78 TVDSKANREKMLRDNNVTDEIGHHFVFDGMILYLKEEWEQNQMIEVQHPIDRSLICIRFKQTNRF 142

  Fly   183 VGFISCAEPRFLQVLNLILRRSMKGLNLELVGRNLF---DPRAKIEIREFKMELWPGYETSIRQH 244
            :    ..:|:.:.:.|.|:|||...|.|..:|||.|   |.||   :.::.|.:.|||||:||.:
 Worm   143 L----VDDPQTINIFNTIIRRSFDALQLTQLGRNYFNWGDSRA---VPDYNMSILPGYETAIRMY 200

  Fly   245 EKDILLGTEITHKVMRTETIYDI----MRRCSHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDV 305
            |::.:|..|...|::|.|::|.:    :|.|.:||.|.|:::........::|.|||:.:|...:
 Worm   201 EENFMLCVENRFKMVREESMYILFHKELRSCQNNPQRVQEKMNEMYGGTTIITRYNNKLHRYTRL 265

  Fly   306 DFGQTPKSTFSCKGRDISFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRV 370
            |:..:|.|.|...|:.|:..||:..:|.|.|...:||::||:.:.|. .....::..::||||..
 Worm   266 DYSISPLSEFVKDGQSITLKEYFKNQYGIEITVDDQPIIISEGKPKQ-PGEPPQVSYIVPELCFP 329

  Fly   371 TGLNAEMRSNFQLMRAMSSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQG 435
            |||..|||.:|::|:.::.:|||:|:||....|.....|....:.::..:.|.:.|.:::..||.
 Worm   330 TGLTDEMRKDFKMMKEIAKHTRMSPQQRLVESRKLIVDLSKNEKVMECFKYWGISLGQDLANVQA 394

  Fly   436 RIIGQQNIVFHNGKVPAGENADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHEL--RTLLDSLY 498
            |::..:.:  ...|...|:.|:|.|..::..:..  ...:..|.||.|...:..|  :..::...
 Worm   395 RVLKSEPL--QGKKTYEGKQAEWARGVKECGIYR--GSNMTNWIVIGPGSGNSGLLSQKFIEEAR 455

  Fly   499 RAASGMGLRIRSPQEFIIYDDRTGTYVRAMDDCVR----SDPKLILCLVPNDNAERYSSIKKRGY 559
            |....:.:::..|....|.......|:..:...::    .|..:::.::.:||..||.|:||...
 Worm   456 RLGKILQVQLGEPMCVPIRGISPNDYLEGVKGAIKQVDGEDIHMLVVMLADDNKTRYDSLKKFLC 520

  Fly   560 VDRAVPTQVVTLKTT--------KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIA 616
            |:..:|.|.|.|:|.        :|::|.||..||.:|:.||.|...|.:.:||...|.:|:|:.
 Worm   521 VECPIPNQCVNLRTLAGKSKDGGENKNLGSIVLKIVLQMICKTGGALWKVNIPLKNTMIVGYDLY 585

  Fly   617 KSTRDRKRAYGALIA--SMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEH-RKLPS 678
            ..:..:.:..||.::  |.|..|   ::|..........|.|.|...:.|||:||...: :.|||
 Worm   586 HDSTLKGKTVGACVSTTSNDFTQ---FYSQTRPHENPTQLGNNLTHFVRKALKQYYDSNDQTLPS 647

  Fly   679 RIVFYRDGVSSGSLKQLFEFEVK------DIIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLN 737
            |::.||||...|.:..:...|||      |.:.....|.:.......:||:|:||:.:|.|....
 Worm   648 RLILYRDGAGDGQIPYIKNTEVKLVRDACDAVTDKAAELSNKVQEKIKLAFIIVTKRVNMRILKQ 712

  Fly   738 GQ------NPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYK 796
            |.      ||.|||:||..:|.|||.|||||.|.|.||||:|.|||:::....|.|:|.|:|.:|
 Worm   713 GSSLDNAINPQPGTVVDTTVTRPERMDFYLVPQFVNQGTVTPVSYNIIHDDTDLGPDKHQQLAFK 777

  Fly   797 MCHLYYNWSGTTRVPAVCQYAKKLATLVGTNLHSIPQNALEKKFYYL 843
            :|||||||.||.||||.||||.|||.|...:||......|..|.::|
 Worm   778 LCHLYYNWQGTVRVPAPCQYAHKLAFLTAQSLHDDANGCLRDKLFFL 824

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	44/137 (32%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	147/472 (31%)
prg-1	NP_492121.1	PAZ	218..354	CDD:198017	44/136 (32%)
		Piwi_piwi-like_Euk	341..807	CDD:240016	147/472 (31%)