Protein Alignment piwi and ppw-1

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_491323.2
• Gene: ppw-1 / 172013
• WormBaseID: WBGene00004093
• Length: 887
• Species: Caenorhabditis elegans
• Alignment Length: 898
• Identity: 186/898 - (20%)
• Similarity: 329/898 - (36%)
• Gaps: 248/898 - (27%)

  Fly    62 REGGPTERKPWGDQYDYLNTRPAELVSKKGTD---GVPVMLQTNFFRLKTKPEWRIVHYHVEF-- 121
            |...|..:|        |.|.|  |.:||..:   |..|.:.||..:|..||...|..|.|:.
 Worm    13 RPAAPAAQK--------LGTAP--LAAKKTRNVERGTKVNIDTNIRKLTIKPNQPIYKYAVQVNY 67

  Fly   122 --------EPSIE------------NPRVRMGVLSNHA-----NLLGSGYLFDGLQ--LFTTRKF 159
                    |.:||            |.:.|...:.|.|     .|...|..|...|  |:|..|.
 Worm    68 VFRKPDGTEATIEMSKSAKKGTEHDNDKTRCQKVYNEAIKRYDELKTGGPFFYDRQASLYTLTKL 132

  Fly   160 EQEIT--VLSGK--------------SKLDIEYKIS----IKFVGFISC---AEPRFLQVLNLIL 201
            :.|..  |::.|              .|:|..::.:    |:...  ||   |:...|:.:|:|:
 Worm   133 KNESISFVVTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIRTTN--SCPANADKTLLEAMNIIV 195

  Fly   202 R-RSMKGLNLELVG---RNLFDPR-AKIEIREF-KMELWPGYETSIRQHEKDI--LLGTE--ITH 256
            . .:.:..|:..||   ..|.||. ..:..:|: :.:|:.|...|     |.:  |.||:  :..
 Worm   196 SGPAFENKNVITVGACVHYLIDPTVVDVAYKEYAEGQLYSGVGAS-----KSVKTLEGTDKKVPS 255

  Fly   257 KVMRTE---TIY--------DIMRRC--------SHNPARHQDEVRVNVLDLIVLTDYN------ 296
            ..|.||   |::        ::::..        :::||..:.|.....||:::  :|.
 Worm   256 LFMTTEMKTTLFHPDYAPLVELLQTFRGFSTTLKANSPAAQRIEKAFVGLDVVL--NYGVHKGLG 318

  Fly   297 --------NRTYRINDVDFGQTPKSTFSCKGRDISFV-EYYLTKYNIRIRDHNQPLLISKNRDKA 352
                    .|.:........:..|||     |:.:.| :|:..||.|.::..:...:.:|.:...
 Worm   319 EDGVVMKIRRFHTSAKETCFEVEKST-----REFTNVFDYFKKKYGITLKYPDLFTIEAKGKQGK 378

  Fly   353 LKTNASELVVLIPELCRVTGLNAEMRSNFQL----MRAMSSYTRMNPKQRTDRL-RAFNHRLQNT 412
            :...| |:::|.|   ..|..|.:|.:|.|.    |.|...:.|   |..||.: |.......|.
 Worm   379 IHFPA-EVLLLCP---NQTVTNDQMINNEQADMIKMSAAQPHIR---KTTTDTIVRNVGLASNNI 436

  Fly   413 PESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGEN------ADWQR--HFRDQRMLT 469
            ...:||....|:|         |.::.:..|.|...::....|      .|:.|  .:.|.:.||
 Worm   437 YGFIKVEDPVNLE---------GMVLPKPKIAFAGNQLADLANPKSRFPTDFNRAGQYYDAKELT 492

  Fly   470 TPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSP-QEFIIYDDRTGTYVRAMDDCVR 533
                   :|.::..|  :.|::.|...|.......|::..:| ..|||..|....:.:|     :
 Worm   493 -------KWELVFVQ--NEEVQGLAKQLADEMVNNGMKCSNPTMSFIIRGDLEPIFKKA-----K 543

  Fly   534 SDPKLILCLVPNDNAERYSSIK--KRGYVDRAVPTQVVTLKTTKN-----RSLMSIATKIAIQLN 591
            :....:|..|.......:..||  ::.|   .|.||.:..:|.:.     ::.::|..|    .|
 Worm   544 AAGTQLLFFVVKSRYNYHQQIKALEQKY---DVLTQEIRAETAEKVFRQPQTRLNIINK----TN 601

  Fly   592 CKLGYTPWMI-------------------------ELPLSGLMTIGFDIAKSTRDRKRAYGALIA 631
            .|||...:.|                         :.|:|    :||........:|.|.|.:..
 Worm   602 MKLGGLNYAIGSEAFNKPNRLIVGFVTSQRVGGNPDYPIS----VGFAANMLKHHQKFAGGYVYV 662

  Fly   632 SMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQL- 695
            ..|    ...|.:        ::.:||     .|:.:...|.|..|..|:.|.:|||.|....:
 Worm   663 HRD----RDVFGS--------IIKDTL-----LAIFKTCTEQRGRPDDILLYFNGVSEGQFSMIN 710

  Fly   696 --FEFEVKDIIEKLKTEYARVQLSP---PQLAYIVVTRSMNTRFFLNGQ----NPPPGTIVDDVI 751
              |...||:.....:.|.     :|   |.:..|..:::.|.|.:.:.:    |..|||:||..|
 Worm   711 EEFSARVKEACMAFQKEG-----TPPFRPHITIIASSKAHNERLYKSDKGRIVNLEPGTVVDHTI 770

  Fly   752 TLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPE-----KMQKLTYKMCH 799
            ......::|..|...||||...|.:.:::::.. .|:     .:::||..:|:
 Worm   771 VSNVYTEWYHASAVARQGTAKATKFTLIFTTKA-GPQAEPLWHLEQLTNDLCY 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	31/171 (18%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	98/479 (20%)
ppw-1	NP_491323.2	PAZ_argonaute_like	272..389	CDD:239212	19/124 (15%)
		Piwi-like	444..849	CDD:239208	87/436 (20%)