Protein Alignment piwi and sago-2

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_490758.1
• Gene: sago-2 / 171653
• WormBaseID: WBGene00018921
• Length: 887
• Species: Caenorhabditis elegans
• Alignment Length: 903
• Identity: 190/903 - (21%)
• Similarity: 327/903 - (36%)
• Gaps: 266/903 - (29%)

  Fly    70 KPWGDQYDYLNTRPAELVSKKGTD---GVPVMLQTNFFRLKTKPEWRIVHYHVEF---------- 121
            ||.......|.|.|  |.:||..:   |..|.:.||..:|..||...|..|.|:.
 Worm    13 KPAAPAAQKLGTAP--LAAKKTRNEEWGTKVNIDTNIRKLTIKPNQPIYKYAVQVNYVFRKPDGT 75

  Fly   122 EPSIE------------NPRVRMGVLSNHA-----NLLGSGYLFDGLQ--LFTTRKFEQEIT--V 165
            |.:||            |.:.|...:.|.|     .|...|..|...|  |:|..|.:.|..  |
 Worm    76 EATIEMSKSAKKGTEHDNDKTRCQNVYNEAIKRYDELKTGGPFFYDRQASLYTLTKLKNESISFV 140

  Fly   166 LSGK--------------SKLDIEYKIS----IKFVGFISC---AEPRFLQVLNLILR-RSMKGL 208
            ::.|              .|:|..::.:    ||...  ||   |:...|:.:|:|:. .:.:..
 Worm   141 VTDKICKRQNFKEAQFVLKKVDQSFQSTSNDVIKTTN--SCPANADKTLLEAMNIIVSGPAFENK 203

  Fly   209 NLELVG---RNLFDPR-AKIEIREF-KMELWPGYETSIRQHEKDI--LLGTE--ITHKVMRTE-- 262
            |:..||   ..|.||. ..:..:|: :.:|:.|...|     |.:  |.||:  :....|.||
 Worm   204 NVITVGACVHYLIDPTGVDVAYKEYPEGQLYSGVGVS-----KSVKTLEGTDKKVPSLFMTTEMK 263

  Fly   263 -TIY--------DIMRRC--------SHNPARHQDEVRVNVLDLIVLTDYN-------------- 296
             |::        ::::..        :::||..:.|.....||:::  :|.
 Worm   264 TTLFHPDYAPLVELLQTFRGFSTTLKANSPAAQRIEKAFVGLDVVL--NYGVHKGLGEDGVVMKI 326

  Fly   297 NRTYRINDVDFGQTPKSTFSCKGRDISFV-EYYLTKYNIRIRDHNQPLLISKNRDKALKTNASEL 360
            .|.:........:..|||     |:.:.| :|:..||.|.::..:...:.:|.:...:...| |:
 Worm   327 RRFHTSAKETCFEVEKST-----REFTNVFDYFKKKYGITLKYPDLFTIEAKGKQGKIHFPA-EV 385

  Fly   361 VVLIPELCRVTGLNAEMRSNFQL----MRAMSSYTRMNPKQRTDRL-RAFNHRLQNTPESVKVLR 420
            ::|.|   ..|..|.:|.:|.|.    |.|...:.|   |..||.: |.......|....:||..
 Worm   386 LLLCP---NQTVTNDQMINNEQADMIKMSAAQPHIR---KTTTDTIVRNVGLASNNIYGFIKVED 444

  Fly   421 DWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGEN------ADWQR--HFRDQRMLTTPSDGLDR 477
            ..|:|         |.::.:..|.|...::....|      .|:.|  .:.|.:.||       :
 Worm   445 PVNLE---------GMVLPKPKIAFAGNRLADLANPKSRFPTDFNRAGQYYDAKELT-------K 493

  Fly   478 WAVIAPQRNSHELRTLLDSLYRAASGMGLRIRSP-QEFIIYDDRTGTYVRAMDDCVRSDPKLILC 541
            |.::..|  :.|::.|...|.......|::..:| ..|||..|....:.:|     ::....:|.
 Worm   494 WELVFVQ--NEEVQGLAKQLADEMVNNGMKCSNPTMSFIIRGDLEPIFKKA-----KAAGTQLLF 551

  Fly   542 LVPNDNAERYSSIK--KRGYVDRAVPTQVVTLKTTKN-----RSLMSIATKIAIQLNCKLGYTPW 599
            .|.......:..||  ::.|   .|.||.:..:|.:.     ::.::|..|    .|.|||...:
 Worm   552 FVVKSRYNYHQQIKALEQKY---DVLTQEIRAETAEKVFRQPQTRLNIINK----TNMKLGGLNY 609

  Fly   600 MI-------------------------ELPLSGLMTIGF--DIAKS-----------TRDRKRAY 626
            .|                         :.|:|    :||  ::.|.           .|||. .:
 Worm   610 AIGSEAFNKPNRLIVGFVTSQRVGGNPDYPIS----VGFAANMLKHHQKFAGGYVYVHRDRD-VF 669

  Fly   627 GALIASMDLQQNSTYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGS 691
            |::|....|    |.|.|.|                         |.|..|..|:.|.:|||.|.
 Worm   670 GSIIKDTLL----TIFKTCT-------------------------EQRGRPDDILLYFNGVSEGQ 705

  Fly   692 LKQL---FEFEVKD---IIEKLKTEYARVQLSPPQLAYIVVTRSMNTRFFLNGQ----NPPPGTI 746
            ...:   |...||:   ..:|..|...|     |.:..|..:::.|.|.:.:.:    |..|||:
 Worm   706 FSMINEEFSARVKEACMAFQKEGTPPFR-----PHITIIASSKAHNERLYKSDKGRIVNLEPGTV 765

  Fly   747 VDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPE-----KMQKLTYKMCH 799
            ||..|......::|..|...||||...|.:.:::::.. .|:     .:::||..:|:
 Worm   766 VDHTIVSNVYTEWYHASAVARQGTAKATKFTLIFTTKA-GPQAEPLWHLEQLTNDLCY 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	31/171 (18%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	102/492 (21%)
sago-2	NP_490758.1	PAZ_argonaute_like	272..389	CDD:239212	19/124 (15%)
		Piwi-like	444..849	CDD:239208	91/449 (20%)