Protein Alignment piwi and piwil3

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_031752134.1
• Gene: piwil3 / 100496286
• XenbaseID: XB-GENE-6469412
• Length: 869
• Species: Xenopus tropicalis
• Alignment Length: 861
• Identity: 319/861 - (37%)
• Similarity: 481/861 - (55%)
• Gaps: 69/861 - (8%)

  Fly     6 GRGRRRPLNEDDSSTSRGSGDGPRVKVFRGSSSGDPRA-DPRIEASRERRALEEAPRREGGPTER 69
            ||||:|               |......|      ||| ||..|.|   ...:|....|.|...|
 Frog    55 GRGRQR---------------GAAAAAVR------PRAEDPVQEIS---AGFQEVTISERGGRRR 95

  Fly    70 KPWGDQYDY-LNTRPA-ELV--SKKGTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRV 130
                |.:|. :|||.. |.|  ||.|..|..:.|.||..:|.::|:|.:..||:::.|.:|:.|:
 Frog    96 ----DFHDLGVNTRQTIEHVKESKTGVSGSTIQLSTNHIKLVSRPQWVLYQYHIDYNPQMESRRL 156

  Fly   131 RMGVLSNHANLLGSGYLFDGLQLFTTRKFEQEITVLSGKSKLDIEYKISIKFVGFISCAEPRFLQ 195
            |..:|..|..|:|....|||..||..::..:...|.| :::.....||:|.....:....|...|
 Frog   157 RTALLYQHEELIGKARAFDGTMLFAPKRLNKATEVFS-QTRNGENVKITITLTNELPPTSPTCFQ 220

  Fly   196 VLNLILRRSMKGLNLELVGRNLFDPRAKIEIREFKMELWPGYETSIRQHEKDILLGTEITHKVMR 260
            ..|:|.||.:|.:|::.:|||.::|...|||.:..:.:|||:.|||.|:|..|:|..:::|||:|
 Frog   221 FYNIIFRRLLKMMNMKQIGRNYYNPSDPIEISQHNLTIWPGFTTSILQYETSIMLSLDVSHKVLR 285

  Fly   261 TETIYDIMRRC--SHNPARHQDEVRVNVLDLIVLTDYNNRTYRINDVDFGQTPKSTF-SCKGRDI 322
            :||:.|:|.:.  .|......|.|...:|..||||.|||:||||:::.:..||:||| ...|.||
 Frog   286 SETVLDVMTKLYRMHGDRDFADAVTKELLGQIVLTKYNNKTYRIDEICWNMTPQSTFKKSDGSDI 350

  Fly   323 SFVEYYLTKYNIRIRDHNQPLLISKNRDKALKTNASELVVLIPELCRVTGLNAEMRSNFQLMRAM 387
            |||:||..:||..|||..|.|:.:..| :......:..:||:||||.:|||...||::|.:||.:
 Frog   351 SFVDYYRMQYNKEIRDLRQALIANIPR-RVRPGGDTGPIVLVPELCNLTGLTDRMRNDFGVMRDL 414

  Fly   388 SSYTRMNPKQRTDRLRAFNHRLQNTPESVKVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPA 452
            :.:||:.|.||..::..|.:.:.......|.||||.:..||.:....||:...:.|      :.|
 Frog   415 AVHTRLPPDQREKQVARFLNYIHKDENVQKELRDWGLNFDKQLLPFVGRVSPPERI------LQA 473

  Fly   453 GEN-------ADWQRHFRDQRMLTTPSDGLDRWAVIAPQRNSHELRTLLDSLYRAASGMGLRIRS 510
            |..       |||.|..|.|.:::...  ||.|.::.|:|.....:||:.:|.:.|..:|:|:.:
 Frog   474 GRTADYNPQFADWSREMRGQTLISVRH--LDNWMLLYPRRCYDAAQTLVQTLNKVAQQIGMRMNN 536

  Fly   511 PQEFIIYDDRTGTYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPTQVVTLKT-T 574
            .:.|.: |||..:|::.::..|..|.::::|::.:.:.|:|.||||...:....|:|.|..:| :
 Frog   537 VRMFEV-DDRANSYIQVLNAEVNPDTQMVVCVLSSIHKEKYDSIKKYLCLQIPTPSQCVVARTLS 600

  Fly   575 KNRSLMSIATKIAIQLNCKLGYTPWMIELPLSGLMTIGFDIAKSTRDRKRAYGALIASMDLQQNS 639
            |.::::|:|||||:|:|||:|...|.:|:||..:|.||.|....|...||:....:|||:.....
 Frog   601 KPQTVLSVATKIAMQMNCKMGGELWSVEIPLGEMMVIGIDCYHDTLSGKRSIAGFVASMNRNLTR 665

  Fly   640 TYFSTVTECSAFDVLANTLWPMIAKALRQYQHEHRKLPSRIVFYRDGVSSGSLKQLFEFEVKDII 704
            .|...|.:....::: :.|...:..:|..:.:.::.|||||:.|||||..|.||.|..:|:...:
 Frog   666 WYSRCVLQDQKQEIV-DGLKVCLQASLHAWFNCNKNLPSRILIYRDGVGDGQLKTLVNYEIPQFL 729

  Fly   705 EKLKT---EYARVQLSPPQLAYIVVTRSMNTRFF--LNG--QNPPPGTIVDDVITLPERYDFYLV 762
            :.:|:   :|.      |:|:.|||.:.:|.|||  |.|  |||||||:||..:|.||.|||::|
 Frog   730 DCIKSAGRDYC------PKLSIIVVKKRINARFFAHLGGRIQNPPPGTVVDVEVTRPEWYDFFIV 788

  Fly   763 SQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLTYKMCHLYYNWSGTTRVPAVCQYAKKLATLVGTN 827
            ||.|||||||||.|||:|.|.||.|:.||:||||:|||||||.|..||||.||||.|||.|||.:
 Frog   789 SQSVRQGTVSPTHYNVVYDSSGLKPDYMQRLTYKLCHLYYNWPGVIRVPAPCQYAHKLAFLVGQS 853

  Fly   828 LHSIPQNALEKKFYYL 843
            :|..|..||..:.|||
 Frog   854 IHKEPHLALSNRLYYL 869

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	56/136 (41%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	175/458 (38%)
piwil3	XP_031752134.1	GAGE	<75..117	CDD:461753	15/48 (31%)
		PAZ	287..423	CDD:198017	56/136 (41%)
		Piwi_piwi-like_Euk	410..852	CDD:240016	175/457 (38%)