Protein Alignment piwi and ago4

DIOPT Version :10

• Sequence 1: NP_476875.1
• Gene: piwi / 34521
• FlyBaseID: FBgn0004872
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_004911629.1
• Gene: ago4 / 100495218
• XenbaseID: XB-GENE-1006882
• Length: 890
• Species: Xenopus tropicalis
• Alignment Length: 872
• Identity: 197/872 - (22%)
• Similarity: 348/872 - (39%)
• Gaps: 220/872 - (25%)

  Fly    91 GTDGVPVMLQTNFFRLKTKPEWRIVHYHVEFEPSIENPRVRMGVLSNHAN-----LLGS---GYL 147
            ||.|.|:.|..|.|:::. |:..:.||.|:.:|.....||...|:.....     :.|.   ||
 Frog    49 GTLGKPIRLLANHFQVQI-PKIDVYHYDVDIKPEKRPRRVNREVVDTMVRHFKMPIFGDRQPGY- 111

  Fly   148 FDGLQ-LFTTR-------KFEQEITVLSGKSKLDIEYKISIKFV-------------GFISCAEP 191
             ||.: ::|..       :.:.|:| |.|:.| |..:|::|::|             |.:|....
 Frog   112 -DGKRNMYTAHPLPIGRDRVDLEVT-LPGEGK-DQTFKVTIQWVSVVSLQLLLEALAGHLSEVPD 173

  Fly   192 RFLQVLNLILRRSMKGLNLELVGRNLFDP-----------RAKIEIREFKMELWPGYETSIRQHE 245
            ..:|.|::|.|. :..:....|||:.|.|           |          |:|.|:..|:|...
 Frog   174 DSVQALDVITRH-LPSMRYTPVGRSFFSPPEGYYHPLGGGR----------EVWFGFHQSVRPAM 227

  Fly   246 KDILLGTEITHKVM-RTETIYDIMRRCSHNPARHQDEVRVNVLDL-------IVLTDYN------ 296
            .:::|..:::.... |.:.:.:.|  |             .|||:       ..|||..
 Frog   228 WNMMLNIDVSATAFYRAQPVIEFM--C-------------EVLDVQNINEQTKPLTDSQRVKFTK 277

  Fly   297 ---------------NRTYRINDVDFGQTPKSTF-----SCKGRDISFVEYYLTKYNIRIRDHNQ 341
                           .|.||:.:|........||     :.:..:.:..:|:..||:::::..:.
 Frog   278 EIRGLKVEVTHCGQMKRKYRVCNVTRRPASHQTFPLQLENGQAMECTVAQYFKQKYSLQLKYPHL 342

  Fly   342 PLLISKNRDKALKTNASELVVLIP-ELCRVTGLNAEMRSNFQLM-RAMSSYTRMNPKQRTDRLRA 404
            |         .|:....:....:| |:|.:.   |..|...:|. ...|:..:...:...||...
 Frog   343 P---------CLQVGQEQKHTYLPLEVCNIV---AGQRCIKKLTDNQTSTMIKATARSAPDRQEE 395

  Fly   405 FNHRLQNTPESV----KVLRDWNMELDKNVTEVQGRIIGQQNIVFHNGKVPAGENADWQRHFRDQ 465
            .: ||..:...|    ..|:::.:.:...:||:.||:: ...::.:.|:|             ..
 Frog   396 IS-RLVKSNSMVGGPDPYLKEFGIVVHNEMTELTGRVL-PAPMLQYGGRV-------------SN 445

  Fly   466 RMLTTPSDG--------------LDRWAV--IAPQRNSHE--LRTLLDSLYRAASGMGLRIRSPQ 512
            :.:.||:.|              :..|||  .|||:...|  |::..|.|.:.:...|:.|:...
 Frog   446 KTVATPNQGVWDMRGKQFYAGIEIKVWAVACFAPQKQCREDLLKSFTDQLRKISKDAGMPIQGQP 510

  Fly   513 EFIIYDDRTG-----------TYVRAMDDCVRSDPKLILCLVPNDNAERYSSIKKRGYVDRAVPT 566
            .|..|.....           |||..         :||:.::|. ....|:.:|:.|.....:.|
 Frog   511 CFCKYAQGADSVEPMFKHLKLTYVGL---------QLIVVILPG-KTPVYAEVKRVGDTLLGMAT 565

  Fly   567 QVVTLKTTKNRSLMSIATKIAIQLNCKLG---------YTPWMIELPLSGLMTIGFDIA--KSTR 620
            |.|.:|.....|..:: :.:.:::|.|||         ..|.:.:.|   ::.:|.|:.  .:..
 Frog   566 QCVQVKNVVKTSPQTL-SNLCLKINAKLGGINNVLVPHQRPSVFQQP---VIFLGADVTHPPAGD 626

  Fly   621 DRKRAYGALIASMDLQQNSTYFSTV-TECSAFDVLANTLWP---------MIAKALRQYQHEHRK 675
            .:|.:..|::.||| ...|.|.:|| .:.|..:.....|:.         |:.:.|.|:....|.
 Frog   627 GKKPSIAAVVGSMD-GHPSRYCATVRVQTSRQETTQELLYSQEVIQDLSNMVRELLIQFYKSTRF 690

  Fly   676 LPSRIVFYRDGVSSGSLKQLFEFEVKDIIE---KLKTEYARVQLSPPQLAYIVVTRSMNTRFFL- 736
            .|:||::||.|||.|.:||:...|:..|.:   .|:.:|.      |.:.||||.:..:||.|.
 Frog   691 KPTRIIYYRGGVSEGQMKQVAWPELMAIRKACISLEEDYR------PGITYIVVQKRHHTRLFCA 749

  Fly   737 -------NGQNPPPGTIVDDVITLPERYDFYLVSQQVRQGTVSPTSYNVLYSSMGLSPEKMQKLT 794
                   ...|.|.||.||..||.|..:||||.|....|||..|:.|.||:.....:.:::|.||
 Frog   750 DKTERVGKSGNVPAGTTVDSTITHPSEFDFYLCSHAGIQGTSRPSHYQVLWDDNCFTADELQLLT 814

  Fly   795 YKMCHLYYNWSGTTRVPAVCQYAKKLA 821
            |::||.|...:.:..:||...||:.:|
 Frog   815 YQLCHTYVRCTRSVSIPAPAYYARLVA 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
piwi	NP_476875.1	PAZ	262..396	CDD:198017	26/168 (15%)
		Piwi_piwi-like_Euk	382..826	CDD:240016	124/506 (25%)
ago4	XP_004911629.1	ArgoN	53..182	CDD:465134	31/133 (23%)
		ArgoL1	193..243	CDD:462567	12/59 (20%)
		PAZ_argonaute_like	244..364	CDD:239212	22/143 (15%)
		Piwi_ago-like	411..848	CDD:240015	117/466 (25%)