Protein Alignment YL-1 and VPS72

DIOPT Version :10

• Sequence 1: NP_609475.1
• Gene: YL-1 / 34516
• FlyBaseID: FBgn0032321
• Length: 351
• Species: Drosophila melanogaster
• Sequence 2: NP_001258016.1
• Gene: VPS72 / 6944
• HGNCID: 11644
• Length: 375
• Species: Homo sapiens
• Alignment Length: 358
• Identity: 141/358 - (39%)
• Similarity: 190/358 - (53%)
• Gaps: 60/358 - (16%)

  Fly     1 MAASRSRRNNAGNKIAHLLNEEEEDDFYKTSYGGFQEDEEDKEYE-QKDEEEDVVDSDFSIDEND 64
            :|..|:.|..|||:::.||..||||:||:|:||||.|:..|.||: .:.:.||.|||||.|||.|
Human     3 LAGGRAPRKTAGNRLSGLLEAEEEDEFYQTTYGGFTEESGDDEYQGDQSDTEDEVDSDFDIDEGD 67

  Fly    65 EPVSDQEEAPEKKRKRGVVNTKAYKETKPAVKKETKATPALHKKRPGGGVTKRRPRPRFTVL--- 126
            ||.|| .||.|.:|||.|| ||||||...:::.....|||       |...|.|.......|
Human    68 EPSSD-GEAEEPRRKRRVV-TKAYKEPLKSLRPRKVNTPA-------GSSQKAREEKALLPLELQ 123

  Fly   127 DSG---RKSIRTSTAIKTQATKIRLKELDDARKRKKKKVRVEDYMPTQEELLEEAKITEEENTKS 188
            |.|   |||:|.|||..|:.|.:|::| ...:.|::|....|..: ||||||.|||||||.|.:|
Human   124 DDGSDSRKSMRQSTAEHTRQTFLRVQE-RQGQSRRRKGPHCERPL-TQEELLREAKITEELNLRS 186

  Fly   189 LEKFQKMELEKKKSRPTKRTFSGPTIRYHSLTMPAMRKPTRGANPAVDSKDLAG----------- 242
            ||.::::|.:|||....||...||.|.|||:|:|.:.:|    .|..::.|:.|
Human   187 LETYERLEADKKKQVHKKRKCPGPIITYHSVTVPLVGEP----GPKEENVDIEGSLCFSLSFVLR 247

  Fly   243 -----------------------KCERTFVTIENDFNDKVFQSLFRHKAPPKAS-NGICPITRLP 283
                                   :|.|||:|..   :|..|:..|....|||.. ..:||:|..|
Human   248 LDPAPSVSALTPHAGTGPVNPPARCSRTFITFS---DDATFEEWFPQGRPPKVPVREVCPVTHRP 309

  Fly   284 ARYFDPITQQPYYSIQAFKILREAYYMQLEQQG 316
            |.|.||:|..||.:.:||||:||||...:...|
Human   310 ALYRDPVTDIPYATARAFKIIREAYKKYITAHG 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YL-1	NP_609475.1	YL1	5..218	CDD:461734	101/219 (46%)
		YL1_C	276..304	CDD:198061	14/27 (52%)
VPS72	NP_001258016.1	YL1	7..216	CDD:461734	101/219 (46%)
		YL1_C	302..330	CDD:462412	14/27 (52%)