Protein Alignment Myo31DF and MYO19

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_011523588.1
• Gene: MYO19 / 80179
• HGNCID: 26234
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 937
• Identity: 263/937 - (28%)
• Similarity: 422/937 - (45%)
• Gaps: 187/937 - (19%)

  Fly     9 VQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQM-NIYGPETIRKY-------- 64
            :.|...::.|::|..:..|:.|:...:.||..|...|::||::.: .:|.||.:|:|
Human    37 LDDLTRVNPVTLETVLRCLQARYMADTFYTNAGCTLVALNPFKPVPQLYSPELMREYHAAPQPQQ 101

  Fly    65 ---------------KGRELFEN---------APHLFAIADSAYRVLKQ--RQQDTCILISGESG 103
                           .||.|...         .||:|.:.:..||.:|.  ...:..|::|||||
Human   102 CGHSESASATACPIGAGRILNHEELTTGQKKLKPHVFTVGEQTYRNVKSLIEPVNQSIVVSGESG 166

  Fly   104 AGKTEASKIIMKYIAAVTNAQGQNE----IERVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYM 164
            ||||..|:.:||:.|.|..:....|    .||::..::.||.::|.||||.|.||:|||||||::
Human   167 AGKTWTSRCLMKFYAVVATSPASWESHKIAERIEQRILNSNPVMEAFGNACTLRNNNSSRFGKFI 231

  Fly   165 DIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYL 229
            .::.:......|..:..|||||:||..|...|||||.|||:.:||:::|..|:.| .|...:.:|
Human   232 QLQLNRAQQMTGAAVQTYLLEKTRVACQASSERNFHIFYQICKGASEDERLQWHL-PEGAAFSWL 295

  Fly   230 NQGSMDILTEKSDYKGTCNAFKTLGFSTDEVQTIWRT---------------------------- 266
            ......:  |:..::.|..|...||..|.....|::|
Human   296 PNPERSL--EEDCFEVTREAMLHLGIDTPTQNNIFKTAPEQQEGIDRMAWQSRKGGHFREVAMQW 358

  Fly   267 ----------------IAAVLHLGNVEFQTIEDELV-------ISNKQHLKSTAKLLQVTETELS 308
                            :|.:|||||::|...|||..       ...:..:::.|.||.:.|..|.
Human   359 KVTLTSRWGLLRHCQVLAGLLHLGNIQFAASEDEAQPCQPMDDAKCEDSVRTAASLLGLPEDVLL 423

  Fly   309 TALTKRVIAAG--GNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFN 371
            ..:..|.|.||  ..|.:|.....:.:..:|.|||.||.|||.|::|.||.:|.   :.|.: :.
Human   424 EMVQIRTIRAGRQQQVFRKPCARAECDTRRDCLAKLIYARLFDWLVSVINSSIC---ADTDS-WT 484

  Fly   372 SVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKII 436
            :.||:||:||||.|..||.||.||||.||||||.|:...|:.:||||..||:||:.|.|.:|:..
Human   485 TFIGLLDVYGFESFPDNSLEQLCINYANEKLQQHFVAHYLRAQQEEYAVEGLEWSFINYQDNQPC 549

  Fly   437 CDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHP---HYTSRQLKPTDKELKHREDF 498
            .||:|.....|.::::|.|......:...|...::..|:..|   |          .:|.....|
Human   550 LDLIEGSPISICSLINEECRLNRPSSAAQLQTRIETALAGSPCLGH----------NKLSREPSF 604

  Fly   499 RITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRP------- 556
            .:.||||.|.|:..|.:|||||.:..:..|||..|:|..|..::|...::  ||.:.|
Human   605 IVVHYAGPVRYHTAGLVEKNKDPIPPELTRLLQQSQDPLLMGLFPTNPKE--KTQEEPPGQSRAP 667

  Fly   557 -LTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAG 620
             ||..:.|:.|:..|:..|....|.|:||||||....:..|.:|.|..|:...||:|.:.:..||
Human   668 VLTVVSKFKASLEQLLQVLHSTTPHYIRCIKPNSQGQAQTFLQEEVLSQLEACGLVETIHISAAG 732

  Fly   621 FVHRQRYDKFLLRYKMI------------SQYT---WPNFRAGSDRDGVRVLIEE---------- 660
            |..|..:..|:.|||::            |.|.   .|.:...|:...:..||::
Human   733 FPIRVSHRNFVERYKLLRRLHPCTSSGPDSPYPAKGLPEWCPHSEEATLEPLIQDILHTLPVLTQ 797

  Fly   661 ---------KKFAQDVKYGHTKIFIRSPRTLFALE----------------------HQRNEMIP 694
                     :.....:..|.||:|: :...|..||                      |:..|...
Human   798 AAAITGDSAEAMPAPMHCGRTKVFM-TDSMLELLECGRARVLEQCARCIQGGWRRHRHREQERQW 861

  Fly   695 HIVTLLQKRVRGWIVRRNFKKMKAAITIV-RAYKAYKLRSYVQELANRLRKAKQMRDYGKS-IQW 757
            ..|.|:|..:|.|:.|::.:::.||.|:: ||::.:::|  :..||.:.....:.:.:.:: ...
Human   862 RAVMLIQAAIRSWLTRKHIQRLHAAATVIKRAWQKWRIR--MACLAAKELDGVEEKHFSQAPCSL 924

  Fly   758 PQPPLAGRKVEAKLHRMFDFWRANMIL 784
            ...||..|.:||    :...|...::|
Human   925 STSPLQTRLLEA----IIRLWPLGLVL 947

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	235/792 (30%)
		Myosin_TH1	801..977	CDD:461801
MYO19	XP_011523588.1	MYSc_Myo19	49..823	CDD:276846	235/793 (30%)