Protein Alignment Myo31DF and MYO9A

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_011519915.1
• Gene: MYO9A / 4649
• HGNCID: 7608
• Length: 2638
• Species: Homo sapiens
• Alignment Length: 1298
• Identity: 314/1298 - (24%)
• Similarity: 539/1298 - (41%)
• Gaps: 390/1298 - (30%)

  Fly    11 DFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFENAPH 75
            |...|..::.:..::|||.||::..||||:|.:.:.:||::.:.||.|:.::.|...:|.:..||
Human   150 DLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPH 214

  Fly    76 LFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTN---AQGQNEIERVKNVLI 137
            ::|:||.||..:.||:::.||:||||||:|||:::..::.::.|::.   |.|      |:.:::
Human   215 IYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASG------VEQIIL 273

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            .:..:||.||||||..|:|||||||::.:.:......:|..:..|||||||:|.|:..|||:|.|
Human   274 GAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVF 338

  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQGSMDILTE---------------------KSDYKGT 246
            |.||.||:::|...:.| |:..:||||||.:...|.:                     :.|::..
Human   339 YYLLAGASEDERSAFHL-KQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERL 402

  Fly   247 CNAFKTLGFSTDEVQTIWRTIAAVLHLGNVEF--QTIEDELV-ISNKQHLKSTAKLLQVTETELS 308
            ..|.:.:||.....:.|:..::|:|||||:.:  :|..|:.: |.|.:.|...::||:|.|..|.
Human   403 QLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLF 467

  Fly   309 TALTKRVIAAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI-----LFRGSKTQA 368
            .||..|.....|..:...:...:|...::::||::|..||.||:.|||.|:     |...:||.:
Human   468 EALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLS 532

  Fly   369 RFNSVIGVLDIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNN 433
                 ||||||:|||.:::|||||||||:.||:||..|.:.:.|.|||||:.|||.|.||:|.:|
Human   533 -----IGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDN 592

  Fly   434 KIICDLVEQPHKGIIAIMDEACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLK-PTDKELKHRED 497
            ....:|:.:...|::.::||.. :..:.|:.|||   ||  .||.|..:..:: |...|    ..
Human   593 TCCINLISKKPTGLLHLLDEES-NFPQATNQTLL---DK--FKHQHEDNSYIEFPAVME----PA 647

  Fly   498 FRITHYAGDVIYNINGFIEKNKDTLYQDFKRLLHNSKDANLSEM----------W---------- 542
            |.|.||||.|.|.:..|.|||.|.:..|...||.:||:|.:|.|          |
Human   648 FIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAM 712

  Fly   543 ----PEGAQDIKKTT-------------------------------------------------- 553
                ..|.::|.:.|
Human   713 VAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTP 777

  Fly   554 ----------------------------------------------------------------- 553
                                                                             
Human   778 LSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTR 842

  Fly   554 ------------------------------------------KRPLTAGTLFQRSMADLVVTLLK 576
                                                      |:|.:....||.|::.|:.||.:
Human   843 NKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQ 907

  Fly   577 KEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYT 641
            .||::|:||:.|..|....|.:..|..|:||.|:||.:|:|::|:..:..:..|:..:.::..
Human   908 AEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLP-- 970

  Fly   642 WPNFRAGSDRDGVRVLIEEKKFAQD-----------VKYGHTKIFIRSP--RTLFALEHQRNEMI 693
                         |.:|..|...||           .:.|.|.:|::..  :.|..|.||  |::
Human   971 -------------RNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQ--EVL 1020

  Fly   694 PHIVTLLQKRVRGWIVRRNFKKMKAAITIVRAYKAYKLRSYVQELANRLRKAKQMRDYGKSIQWP 758
            ..|: |||:..|..:.|::|..::.|..|::.:    .|:|:.:        ||:||  .::|
Human  1021 RRII-LLQRWFRVLLCRQHFLHLRQASVIIQRF----WRNYLNQ--------KQVRD--AAVQ-- 1068

  Fly   759 QPPLAGRKVEAKLHRMFDFWRANMILHKY---------PRSEW-PQLRLQIIAATALAGRRPYWG 813
            :.........|.|...   |||::...:|         .:.:| ...|.:.:||..:..|...:.
Human  1069 KDAFVMASAAALLQAS---WRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYR 1130

  Fly   814 QARRW---------------------------------------------VGDYLANSQENSGYE 833
            :::|:                                             .|.......:.||:|
Human  1131 ESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWE 1195

  Fly   834 --AYNGSIKNIRNHPADGETFQQVLFSSFVKKFNHF-------NKQANRAFIVSDSTIHKLDGIK 889
              :::..||.|       |..:.|:.|:.:.:.:..       |||..||        ....|:
Human  1196 DCSFDNRIKAI-------EECKSVIESNRISRESSVDCLKESPNKQQERA--------QSQSGV- 1244

  Fly   890 NKFKDMKRTIKIRE-------LTSISVSPGRDQLIVFHSSKNKDL---VFSLESEYTPLKEDRIG 944
                |::..:.:||       |....|...:.:     |.:.::|   :||||.    ||...:|
Human  1245 ----DLQEDVLVRERPRSLEDLHQKKVGRAKRE-----SRRMRELEQAIFSLEL----LKVRSLG 1296

  Fly   945 EVVGIVCKKYH-DLTGTELRVNVTTNISCRLDGKARIITVEAASNVEVPNFRPKEGNIIFEVP 1006
            .:.....:::. :|....|:....|..|....|...:::.|.:...::.:....||::.|..|
Human  1297 GISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSP 1359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	239/880 (27%)
		Myosin_TH1	801..977	CDD:461801	38/240 (16%)
MYO9A	XP_011519915.1	RA_Myosin-IXa	15..110	CDD:340736
		MYSc_Myo9	160..1004	CDD:276836	239/880 (27%)
		C1_Myosin-IXa	2067..2124	CDD:410433
		RhoGAP_myosin_IX	2133..2318	CDD:239842