Protein Alignment Myo31DF and MYO7A

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: XP_011543348.2
• Gene: MYO7A / 4647
• HGNCID: 7606
• Length: 2258
• Species: Homo sapiens
• Alignment Length: 825
• Identity: 297/825 - (36%)
• Similarity: 465/825 - (56%)
• Gaps: 60/825 - (7%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFEN 72
            ||:|.:.|..::....:.||..|:::..||||.|.:.|::|||:.::||.||.||:|..:::.|.
Human    96 GVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEM 160

  Fly    73 APHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIERVKNVLI 137
            .||:|||||:.|..:|:..:|.|.:|||||||||||::|:|::::||::   ||:  ..::..::
Human   161 PPHIFAIADNCYFNMKRNSRDQCCIISGESGAGKTESTKLILQFLAAIS---GQH--SWIEQQVL 220

  Fly   138 QSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERNFHSF 202
            ::..|||.||||||.|||||||||||:||.|:.:....|..|..||||||||.:|...|||:|.|
Human   221 EATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQALDERNYHVF 285

  Fly   203 YQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEVQTIW 264
            |.:|.|.::::.::..| .:...|:||..|   :.:...:..:|....:|.|.|.|:..|...|.
Human   286 YCMLEGMSEDQKKKLGL-GQASDYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEIS 349

  Fly   265 RTIAAVLHLGNVEFQ--TIED----ELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVM 323
            :.:||:|||||::::  |.|:    |::.|  ..|.:.|.||:|...:|.:.||.|.:...|..:
Human   350 KLLAAILHLGNLQYEARTFENLDACEVLFS--PSLATAASLLEVNPPDLMSCLTSRTLITRGETV 412

  Fly   324 QKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQARFNSVIGVLDIYGFEIFDSN 388
            ....:..||...:||..|.||.|||.||:.:||.||....|:........||:|||:|||.|..|
Human   413 STPLSREQALDVRDAFVKGIYGRLFVWIVDKINAAIYKPPSQDVKNSRRSIGLLDIFGFENFAVN 477

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            ||||.|||:.||.|||.|:..|.|.|||||..|.|:|.:||:.:|:...|::......||:::||
Human   478 SFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQDALDMIANKPMNIISLIDE 542

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQLKPTDKELKHREDFRITHYAGDVIYNINGFIEKN 518
            .. ...|.||.|:|..::.....:.:|    :.|.:   .|...|.|.|:||.|.|...||:|||
Human   543 ES-KFPKGTDTTMLHKLNSQHKLNANY----IPPKN---NHETQFGINHFAGIVYYETQGFLEKN 599

  Fly   519 KDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFYVR 583
            :|||:.|..:|:|:|::..:.:::........:|.||..|..:.|:||:..|:.||...:||:||
Human   600 RDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVR 664

  Fly   584 CIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFRAG 648
            |||||:.|...:||......|:||.|::|.:|:||||:..|..:.:|:.||:::.....|.::.|
Human   665 CIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRRAGYPIRYSFVEFVERYRVLLPGVKPAYKQG 729

  Fly   649 SDRDGVRVLIEEKKFA-QDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRN 712
            ..|...:.:.|..... .|.:.|.||||::....:. ||.:|::.|...|.||||.:||:..|.|
Human   730 DLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDML-LEVERDKAITDRVILLQKVIRGFKDRSN 793

  Fly   713 FKKMKAAITIV-RAYKAYKLR-SY---------VQELANRLRKAKQMRDYGKSIQWPQPPLAGRK 766
            |.|:|.|.|:: |.::.:..| :|         :|.| :|.||..|           |..||.::
Human   794 FLKLKNAATLIQRHWRGHNCRKNYGLMRLGFLRLQAL-HRSRKLHQ-----------QYRLARQR 846

  Fly   767 V---EAKLHRMFDFWRANMILHKYPRSEWPQLRLQIIAATALAGR 808
            :   :|:.       ||.::...:....|..|.:|..|...:|.|
Human   847 IIQFQARC-------RAYLVRKAFRHRLWAVLTVQAYARGMIARR 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	254/665 (38%)
		Myosin_TH1	801..977	CDD:461801	3/8 (38%)
MYO7A	XP_011543348.2	MYSc_Myo7	109..759	CDD:276832	254/665 (38%)
		CBD_MYO6-like	<796..>839	CDD:409646	13/54 (24%)
		tolA	<826..>996	CDD:236545	18/78 (23%)
		MAP7	<887..963	CDD:461709
		MyTH4	1047..1283	CDD:214535
		FERM1_F1_Myosin-VII	1287..1385	CDD:340612
		B41	1289..1504	CDD:214604
		FERM_C1_MyoVII	1498..1634	CDD:270019
		SH3	1635..1699	CDD:473055
		MyTH4	1793..1926	CDD:214535
		FERM2_F1_Myosin-VII	1931..2028	CDD:340613
		B41	1933..2145	CDD:214604