Protein Alignment Myo31DF and MYO1C

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001074248.1
• Gene: MYO1C / 4641
• HGNCID: 7597
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1064
• Identity: 422/1064 - (39%)
• Similarity: 597/1064 - (56%)
• Gaps: 117/1064 - (10%)

  Fly     8 GVQDFVLLDQVSME-KFMDNLRKRFQNGSIYTYIGEVCVSMNPYRQMNIYGPETIRKYKGRELFE 71
            ||||||||:..:.| .|::|||:||:...||||||.|.||:||||.:.||..:.:.:|:|...:|
Human    47 GVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYE 111

  Fly    72 NAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAVTNAQGQNEIER---VK 133
            ..|||||:||:.||.|:..::|..::||||||||||||:|.::::.|....|.     ||   |:
Human   112 VPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAP-----ERGGAVR 171

  Fly   134 NVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADPVGGIITNYLLEKSRVVQQQPGERN 198
            :.|:|||.:||.||||||.|||||||||||||::||:|..||||.|.:|||||||||.|..||||
Human   172 DRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERN 236

  Fly   199 FHSFYQLLRGANDNELRQYELQKETGKYHYLNQG---SMDILTEKSDYKGTCNAFKTLGFSTDEV 260
            ||.|||||.|..:..||:..|::....|.||.:|   .:..:.:|||:|....|...:.|:.|||
Human   237 FHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEV 301

  Fly   261 QTIWRTIAAVLHLGNVEFQTIED-ELVISNKQHLKSTAKLLQVTETELSTALTKRVIAAGGNVMQ 324
            :.:...:|:||||||:.|...|: ...::.:..||...:||.|..:.|..|||.|.|.|.|..:.
Human   302 EDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELL 366

  Fly   325 KDHNATQAEYGKDALAKAIYDRLFTWIISRINRAILFRGSKTQA-RFNSVIGVLDIYGFEIFDSN 388
            ...|..||.|.:||||||:|.|.|||::.:|||::..:..::.: |..:|:|:|||||||:|..|
Human   367 SPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHN 431

  Fly   389 SFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQPHKGIIAIMDE 453
            |||||||||||||||||||||.||.|||||:.|||.|..::||||||||||||:..||||:|:||
Human   432 SFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDE 496

  Fly   454 ACLSVGKVTDDTLLGAMDKNLSKHPHYTSRQL--KPTDKELKHREDFRITHYAGDVIYNINGFIE 516
            .||..|:.||.|.|..::..:..|||:.:.:|  :.|.|.| .|.:||:.||||:|.|::.||::
Human   497 ECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSL-GRGEFRLLHYAGEVTYSVTGFLD 560

  Fly   517 KNKDTLYQDFKRLLHNSKDANLSEMWPEGAQDIKKTTKRPLTAGTLFQRSMADLVVTLLKKEPFY 581
            ||.|.|:::.|..:.:||:..:|:.:.......|   |||.|..|.|:.|:..||..|..|||.|
Human   561 KNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDK---KRPETVATQFKMSLLQLVEILQSKEPAY 622

  Fly   582 VRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAGFVHRQRYDKFLLRYKMISQYTWPNFR 646
            ||||||||.|....|||..:.|||:|||||||||||||||.:|::|:.||.|||.:...|||.:
Human   623 VRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTW- 686

  Fly   647 AGSDRDGVRVLIEEKKF-AQDVKYGHTKIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVR 710
            ||..:|||.||:....: .::.|.|.||||||.|:||||.|.........:.|.:|...||:..|
Human   687 AGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWR 751

  Fly   711 RNFKKMKAAITIVRAY--------KAYK-----------LRSYVQELANR--------------- 741
            :.|.::|.:...::::        ||.|           :|.:|...|.|
Human   752 QKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSF 816

  Fly   742 -LRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHKYPRS---EW-PQLRLQIIA 801
             |...:|:........||.||.|.|:....|.   :....||: .||.||   || .||:.:.:|
Human   817 LLNLRRQLPQNVLDTSWPTPPPALREASELLR---ELCIKNMV-WKYCRSISPEWKQQLQQKAVA 877

  Fly   802 ATALAGRRPYWGQA--RRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGETFQQVLFSSFVKKF 864
            :....|::..:.|:  |.::...|...:.:.......||              :.:.::..|.|:
Human   878 SEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGS--------------EPIQYAVPVVKY 928

  Fly   865 NHFN-KQANRAFIVSDSTIHKLDGIKNKFKDMKRTIKIRELTSISVSPGRDQLIVFH----SSKN 924
            :... |..:|..:::.:.:..::..|     :|:.|....||.||||...|.|.|.|    .:|.
Human   929 DRKGYKPRSRQLLLTPNAVVIVEDAK-----VKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQ 988

  Fly   925 K-DLVFSLESEYTPLKEDRIGEVVGIVCKKYHDLTGTELRVNVTTNISCR------LDGKARIIT 982
            | |:|         |:.|.:.|.          ||.|.|..|...:|:..      ..|..|..|
Human   989 KGDVV---------LQSDHVIET----------LTKTALSANRVNSININQGSITFAGGPGRDGT 1034

  Fly   983 VEAASNVEVPNFRPKEGNIIFEVP 1006
            ::.....|:...:.|.|::....|
Human  1035 IDFTPGSELLITKAKNGHLAVVAP 1058

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	329/667 (49%)
		Myosin_TH1	801..977	CDD:461801	37/189 (20%)
MYO1C	NP_001074248.1	MYSc_Myo1	62..718	CDD:276829	328/665 (49%)
		Actin-binding. /evidence=ECO:0000255|PROSITE-ProRule:PRU00782	608..630		13/21 (62%)
		IQCG	751..781	CDD:467744	6/29 (21%)
		Myosin_TH1	874..1055	CDD:461801	43/218 (20%)