Protein Alignment Myo31DF and hum-2

DIOPT Version :10

• Sequence 1: NP_523538.1
• Gene: Myo31DF / 34445
• FlyBaseID: FBgn0086347
• Length: 1011
• Species: Drosophila melanogaster
• Sequence 2: NP_001317742.1
• Gene: hum-2 / 179321
• WormBaseID: WBGene00002036
• Length: 1811
• Species: Caenorhabditis elegans
• Alignment Length: 1011
• Identity: 331/1011 - (32%)
• Similarity: 500/1011 - (49%)
• Gaps: 175/1011 - (17%)

  Fly     8 GVQDFVLLDQVSMEKFMDNLRKRFQNG-SIYTYIGEVCVSMNPYRQ-MNIYGPETIRKYK--GRE 68
            |..|..||..:.....:.||:.||..| |||||.|.|.|::|||.. .:|||.|.|:.|:  |:.
 Worm    80 GKDDLTLLSYLHEPAVLHNLQVRFVKGSSIYTYCGIVLVAINPYADCSHIYGEEIIQVYRGAGKS 144

  Fly    69 LFENAPHLFAIADSAYRVLKQRQQDTCILISGESGAGKTEASKIIMKYIAAV----TNAQGQNEI 129
            ..|..||:||:|:.|:..:....:...|::|||||||||.::|.:|:|:|:|    |...|...|
 Worm   145 AREMDPHIFAVAEEAHFDMGAFGKSQSIIVSGESGAGKTVSAKFVMRYLASVAASKTRNGGTTSI 209

  Fly   130 E-RVKNVLIQSNAILETFGNAKTNRNDNSSRFGKYMDIEFDYKADP-VGGIITNYLLEKSRVVQQ 192
            | ||    :.||.|:|:.|||||.||||||||||::.|.|..:... ||..:..|||||||:|.|
 Worm   210 EARV----LASNPIMESIGNAKTIRNDNSSRFGKFIQINFCERGRRIVGAEMKTYLLEKSRLVFQ 270

  Fly   193 QPGERNFHSFYQLLRGANDNELRQYELQKETGKYHYLNQGS---MDILTEKSDYKGTCNAFKTLG 254
            .|||||:|.||||....|...|:...| .....|.||.||.   :..:.:|:|::....|.:.||
 Worm   271 APGERNYHIFYQLCAARNHQVLKDLHL-GPCESYSYLTQGGDSRIPGVDDKADFEALLKALQLLG 334

  Fly   255 FSTDEVQTIWRTIAAVLHLGNVEFQTIEDELVI--SNKQHLKSTAK-LLQVTETELSTALTKRVI 316
            |...::..::|.:|.:|.||||.|:..|....:  |:.|.:....: ..:::|::|...||:|.|
 Worm   335 FDEKQMSDVFRLLAGLLLLGNVHFENGEGSSAVSASSCQEISRLCREFWKISESDLRIWLTRREI 399

  Fly   317 AAGGNVMQKDHNATQAEYGKDALAKAIYDRLFTWIISRINRAI----LFRGSKTQARFNSVIGVL 377
            .|...::.|.....:|...:|||.|.:|..||.|::.:||.|:    ...|:..:.|.:..||||
 Worm   400 RAVNEIVTKPLTKNEAVRSRDALTKMLYSHLFGWLVDKINEALNEKDKLDGTNQKKRPDRFIGVL 464

  Fly   378 DIYGFEIFDSNSFEQFCINYCNEKLQQLFIELVLKQEQEEYQREGIEWTNIEYFNNKIICDLVEQ 442
            ||||||.||.||||||.|||.||||||.|.:.|.|.|||||.||.|||..:::.:|:...||:|.
 Worm   465 DIYGFETFDVNSFEQFSINYANEKLQQQFNQHVFKLEQEEYIREEIEWVRVDFHDNQPAIDLIEG 529

  Fly   443 PHKGIIAIMDEACLSVGKVTDDTLLGAMDK-NLSKHPHYTSRQLKPTDKELKHREDFRITHYAGD 506
            | .|:|.::||.|..:.....|.|....:. .|.::|.....:::        ..||.:.|:|.|
 Worm   530 P-VGMINLLDEQCKRLNGSDADWLSQLQNSTELKRNPQLAFPKVR--------SNDFIVRHFAAD 585

  Fly   507 VIYNINGFIEKNKDTLYQDFKRLLHNSK----------------DANLSEMWPEGAQDIKKTTKR 555
            |.|:.:||:|||:|.:.:....::..||                .::.|...| |.:.|||
 Worm   586 VTYSTDGFVEKNRDAIGEQLLDVVVASKFPFIRTVIGSTAPTSVSSSSSSSTP-GKRTIKK---- 645

  Fly   556 PLTAGTLFQRSMADLVVTLLKKEPFYVRCIKPNDLKSSTVFDEERVEHQVRYLGLLENLRVRRAG 620
              |..:.|:.|:.:|:..|....|.|||||||||.|.|..|:.:|...|:|..|:||.:|:..||
 Worm   646 --TVASQFRDSLKELMSVLCSTRPHYVRCIKPNDSKISFDFEPKRAIQQLRACGVLETVRISAAG 708

  Fly   621 FVHRQRYDKFLLRYKMISQYT-----WPNFRAGSDRD--------GVRVLIEEKKFAQDVKYGHT 672
            |..|..|::|..||::|  ||     |        ||        ..:..:||.|:|    .|.|
 Worm   709 FPSRYPYEEFARRYRVI--YTKEAALW--------RDKPKQFAELACQQCLEEGKYA----VGKT 759

  Fly   673 KIFIRSPRTLFALEHQRNEMIPHIVTLLQKRVRGWIVRRNFKKMKAAITIV----RAYKAYKLRS 733
            |||:|:.: :..||..|.:.:....|::||..:|::.||.::.|:.::.||    :|:.|::...
 Worm   760 KIFLRTGQ-VAVLERVRLDTLAAAATVIQKMWKGFLARRKYETMRRSLLIVQASLKAFLAFRRIK 823

  Fly   734 YVQ--------ELANR----LRKAKQMRDYGKSIQWPQPPLAGRKVEAKLHRMFDFWRANMILHK 786
            |:|        :.|.|    .||.:|:||....||                .||   :||.:
 Worm   824 YLQMHRAVIVMQSAVRGYLERRKYEQIRDSIIGIQ----------------AMF---KANRV--- 866

  Fly   787 YPRSEWPQLRLQIIAATALAGRRPYWGQARRWVGDYLANSQENSGYEAYNGSIKNIRNHPADGET 851
              |....:||.:..|.|..|..|.|  .|||   :.:||.:
 Worm   867 --RRYVEKLRYEKSAITIQAAWRGY--LARR---EQIANRK------------------------ 900

  Fly   852 FQQVLFSSFVKKFNHFNKQANRAFIVSDSTIHKLD----GIKNKFKDMKRTIKIRELTSISVSPG 912
             :.|:....|:|:  ..|:..|...:...::..|.    |::||..:::..:.|....:
 Worm   901 -KVVMVQCAVRKW--LAKRRLRELKIEARSVGHLQKLNTGLENKIIELQMRLDIANART------ 956

  Fly   913 RDQLIVF-HSSKN-----KDLVFSLESEYTPLKEDR 942
            :::...| .:|||     .||.. :|:|...|.|.|
 Worm   957 KEEAEKFATASKNLQKTKADLAM-MEAERLTLLEAR 991

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo31DF	NP_523538.1	MYSc_Myo1	21..677	CDD:276829	263/705 (37%)
		Myosin_TH1	801..977	CDD:461801	31/152 (20%)
hum-2	NP_001317742.1	MYSc_Myo5	93..764	CDD:276831	263/705 (37%)
		IQ	779..799	CDD:197470	6/19 (32%)
		IQ	826..847	CDD:197470	4/20 (20%)
		CCDC158	<864..1473	CDD:464943	35/172 (20%)
		Myo5_CBD	1429..1803	CDD:271254