DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RluA-2 and RIB2

DIOPT Version :9

Sequence 1:	NP_001188782.2	Gene:	RluA-2 / 34440	FlyBaseID:	FBgn0032256	Length:	547	Species:	Drosophila melanogaster
Sequence 2:	NP_014575.1	Gene:	RIB2 / 854088	SGDID:	S000005427	Length:	591	Species:	Saccharomyces cerevisiae

Alignment Length:	512	Identity:	179/512 - (34%)
Similarity:	262/512 - (51%)	Gaps:	122/512 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SEEKSETQSKEVLSEK---------RKASSTDDEGHVKKVK------LEANSLKTKRPGFSDERY 122
            |::.:...:||:.|.|         |..:..::...||...      ::.:..|||:   :|..|
Yeast     9 SDDFNNLLNKEIESAKEVKLRKFANRNNNRNENSSKVKDASGFRLRVIQTDGHKTKK---TDPDY 70

  Fly   123 DETSYYFENGLRKVYPYFFTFTTFAKGRWVDEKILDVFVREFRAAPPEEYERSLEAGKLTVNSEK 187
            :.|   .:..|||:.|||||:.||.|.||.|.|::||||.|||...|..|.:::..||:.:|.|.
Yeast    71 EVT---IDGPLRKIEPYFFTYKTFCKERWRDRKLVDVFVSEFRDREPSYYSKTIAEGKVYLNDEP 132

  Fly   188 VPKDYKIKHNDLLANVVHRHEVPVTSQPIKIVYMDKDIVVVNKPASIPVHPCGRYRHNTVVFILA 252
            ...|..|:..||:.:.|||||.||||:||.||:.|:||:|::||:||||||.||||.||:..:|.
Yeast   133 ANLDTIIRDGDLITHKVHRHEPPVTSKPIDIVFEDEDILVIDKPSSIPVHPTGRYRFNTITKMLE 197

  Fly   253 KEHNLKNLRTIHRLDRLTSGLLLFGRTAEKARELELQIRTRQVQKEYVCRVEGRFPDGIVECNEK 317
            ::... ::...:|||:.||||:...:|...|..:..|::.|:|.||||.||:|.||.||||.::.
Yeast   198 RQLGY-SVHPCNRLDKPTSGLMFLAKTPLGADRMGDQMKAREVTKEYVARVKGEFPIGIVEVDKP 261

  Fly   318 IDVVSYKI---GVCKVSPK-GKDCKTTFKRIGEVGSDSIVLCKPLTGRMHQIRVHLQFLGYPISN 378
            :..|:.|:   .||::|.: .|..||.|:|:...|..|||.|||||||.||||||||:||:||:|
Yeast   262 VRSVNPKVALNAVCEMSDENAKHAKTVFQRVSYDGQTSIVKCKPLTGRTHQIRVHLQYLGFPIAN 326

  Fly   379 DPLY-NHEVFGPLKGRGG-----DIGGITEEQLISNLISI---HNAENWL--GLEGDQIVSGEIK 432
            ||:| |.:::||..||||     ||        :..|.:|   :.||:|:  ..||:.::.
Yeast   327 DPIYSNPDIWGPDLGRGGLQNYDDI--------VLKLDAIGKTNPAESWIHPHSEGEYLLG---- 379

  Fly   433 DVAASTSVVEAPSVVQAPINSETEKPVISKNLEPSNDATAQIATQTCYEEPDRSFDSKKTTSDPQ 497
                                                                           .|
Yeast   380 ---------------------------------------------------------------RQ 381

  Fly   498 CSECKIN-YRDPGTKDLIMYLHAWKYKGVG---------WEYETELPEWACNSNIDY 544
            |.||:.. |.||||.||.::|||::|:.:.         |.|.|:.||||...:..|
Yeast   382 CEECEAEMYTDPGTNDLDLWLHAFRYESLERNSDTQKPLWSYRTKYPEWALEPHRRY 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RluA-2	NP_001188782.2	S4	157..229	CDD:238095	34/71 (48%)
RluA-2	NP_001188782.2	PseudoU_synth_ScRIB2	202..386	CDD:211331	95/188 (51%)
RIB2	NP_014575.1	rluA_subfam	94..406	CDD:161659	145/387 (37%)
RIB2	NP_014575.1	Inv-AAD	459..580	CDD:408556
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345458
Domainoid	1	1.000	142	1.000	Domainoid score	I1006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	307	1.000	Inparanoid score	I482
Isobase	1	0.950	-	0	Normalized mean entropy	S1507
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002443
OrthoInspector	1	1.000	-	-		mtm9246
orthoMCL	1	0.900	-	-		OOG6_100211
Panther	1	1.100	-	-	O	PTHR21600
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1681
SonicParanoid	1	1.000	-	-		X1265
TreeFam	0	0.000	Not matched by this tool.
	12	11.870