Protein Alignment LManII and Man2a2

DIOPT Version :10

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001425115.1
• Gene: Man2a2 / 308757
• RGDID: 1310238
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 297/1157 - (25%)
• Similarity: 464/1157 - (40%)
• Gaps: 282/1157 - (24%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.||:||.|:||        ....|:|::|:|..|..||.:||::.|.:||.||
  Rat   166 LQVFVVPHSHNDPGWIKTFDKYY--------TEQTQHILNSMVSKLQEDPRRRFLWAEVSFFAKW 222

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |.....:.:.||:.||..|:||...|.|.|.|||.:||.:::||...|.:.|....|  ..||.|
  Rat   223 WDNISAQKRAAVRRLVGNGQLEIATGGWVMPDEANSHYFALVDQLIEGHQWLERNLG--ATPRSG 285

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.:||||||..|..:..:.....|...|:.|..|.....|.:.|.:|..:.:.....|:|...:
  Rat   286 WAVDPFGHSSTMPYLLRRANLTSMLIQRVHYAIKKHFAATHSLEFMWRQTWDSDSSTDIFCHMMP 350

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                :.||.:|....||..:.
  Rat   351 FYSYDVPH------TCGPDPKICCQFDFKRLPGGRINCPWKVPPRAITEANVADRAALLLDQYRK 409

  Fly   286 QSQYYRTNNIIVTMGGDFTYQAAQVY---YKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :|:.:|::.::|.:|.||.|...|.:   :.|..:|..:.|.:..  .::...:.|.|.|..:|:
  Rat   410 KSRLFRSSVLLVPLGDDFRYDKPQEWDAQFFNYQRLFDFLNSKPE--FHVQAQFGTLSEYFDALY 472

  Fly   348 D-AGIT-------WPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQL------ 398
            . .|:.       :|..|.|||.||.....|||||:||||..|..:|.....|:..:.|
  Rat   473 KRTGVEPGARPPGFPVLSGDFFSYADREDHYWTGYYTSRPFYKSLDRVLETHLRGAEVLYSLALA 537

  Fly   399 ----SALAPKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
                |.|..:.|......||..|.|||:.|||||||||.||.|.:||..|:..:..:......||
  Rat   538 HARRSGLTGQYPLSDYAVLTEARRTLGLFQHHDAITGTAKEAVVVDYGVRLLRSLVSLKQVIINA 602

  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVS------------EANDRFALTLYNPLAH 512
            .:.|.:..|:.       |.|: .....|.:....||            :::.|| :.::|||..
  Rat   603 AHYLVLGDKET-------YSFD-PRAPFLQMDDSRVSHDALPERTVIRLDSSPRF-VVVFNPLEQ 658

  Fly   513 TVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVF---LATNIPALGY 574
            .....|.:.|.....|::..:|..|..|        |.::..::|.....|:   :...:||||.
  Rat   659 ERLSVVSLLVNSPRVRVLSEEGQPLSVQ--------ISVQWSSATNMVPDVYQVSVPVRLPALGL 715

  Fly   575 RTYYVE--------------------KLDSTEGNTRSKALPKRTSSVTVIGNSHIQLGFD-TNGF 618
            ....::                    ||..:...|....:....:|...|.|.::|:.|. ..|.
  Rat   716 GVLQLQPDLDGPYTLQSSVHVYLNGVKLSVSRQTTFPLRVVDSGTSDFAISNRYMQVWFSGLTGL 780

  Fly   619 LSEVTADGLTRLVSQE-------FLFYEGAVGNNAEFLNRSSGAYIFRP-NENKIHFATDQVEIE 675
            |..|      |.|.:|       .||..|...:..:     ||||:|.| ||.|.:.......:.
  Rat   781 LKSV------RRVDEEQEQQVDMKLFVYGTRTSKDK-----SGAYLFLPDNEAKPYVPKKPPVLR 834

  Fly   676 VYKGDLVHEVHQKFNDWISQVVRVYNKDSYAEFEWLVG-PIPIDDGIGKEVITRFNSDIASDGIF 739
            |.:|....|| ..:.:...||:|:||..........|. .:.|.|.:.||:..|.::||.|.|.|
  Rat   835 VTEGPFFSEV-AAYYEHFHQVIRLYNLPGVEGLSLDVSFQVDIRDYVNKELALRIHTDIDSQGTF 898

  Fly   740 RTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGS 804
            .||.||.::..||      :..|:  .:..|:||:.....::|...|:.:.|.:|.|.|||.:|.
  Rat   899 FTDLNGFQVQPRK------YLKKL--PLQANFYPMPVMAYIQDSQRRLTLHTAQALGVSSLGNGQ 955

  Fly   805 LELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLP 869
            ||:::.|||::||..|:|:.|.     |..|......|.              :||.|.:.   |
  Rat   956 LEVILDRRLMQDDNRGLGQGLK-----DNKITCNHFRLL--------------LERRTLMS---P 998

  Fly   870 TWKFFSNMED------YSAD---------EWQTAFTNIFSGI-SLVLPKPVHLLTLEPWHENQLL 918
            ...|||.:..      :|::         |..|::.::.|.: |:.|..|..:|
  Rat   999 EPGFFSKLAAMFRGLIFSSNTIRNSKVQQERSTSYPSLLSHMTSMYLNTPPLVL----------- 1052

  Fly   919 VRFEHIMENGEDASYSQPVQFNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNT 983
                             ||              ..||:|                 .|...:|:.
  Rat  1053 -----------------PV--------------AKREST-----------------SPTLHSFHP 1069

  Fly   984 YATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRI--RRETETRQEKKDEGRSSKSTE 1046
            .|: ..|.: .|||:     |.:..|::.|||    |::..|  |:..:...|.|:.|.:..:::
  Rat  1070 LAS-PLPCD-FHLLN-----LRMLPAEDTLPA----ADAALILHRKGFDCGLEAKNLGFNCTTSQ 1123

  Fly  1047 G-------------------------PYNSFKSDSSNQEYIIELSPMEIRTF 1073
            |                         |..| .|:|::    |.|.||||.||
  Rat  1124 GKLALGSLFHGLDVLFLQPTSLTLLYPLAS-PSNSTD----ISLEPMEISTF 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	241/862 (28%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	91/299 (30%)
Man2a2	NP_001425115.1	None