Protein Alignment LManII and Man2a1

DIOPT Version :10

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_037111.2
• Gene: Man2a1 / 25478
• RGDID: 3038
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1131
• Identity: 287/1131 - (25%)
• Similarity: 469/1131 - (41%)
• Gaps: 258/1131 - (22%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.|||||.:.|:        :...|||.:::|..|..|..::||:.|.::..||
  Rat   165 LQVFVVPHSHNDPGWLKTFNDYF--------RDKTQYIFNNMVLKLKEDSSRKFIWSEISYLAKW 221

  Fly   112 WK-EQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRV 175
            |. ...|| :||||.|::.|:||.:.|.|.|.|||||||.::|||...|.:.|....|.  :||.
  Rat   222 WDIIDNPK-KEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLGV--KPRS 283

  Fly   176 GWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL 240
            ||.|||||||..|..:..:.||..|...|:.|..|....:.|..|..|..:.:||...|:....:
  Rat   284 GWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMM 348

  Fly   241 -YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAK 284
             :.:|..|.      .|...|.|    |.|..|                ..||:.|....||..:
  Rat   349 PFYSYDIPH------TCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYR 407

  Fly   285 TQSQYYRTNNIIVTMGGDF---TYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSL 346
            .:|:.:||..::..:|.||   .|....:.|:|.::|..|.|.:.  ...:.:.:.|.|.|..:|
  Rat   408 KKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQP--HLKVKIQFGTLSDYFDAL 470

  Fly   347 HDA--------GITWPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALAP 403
            ..:        ...:|..|.|||.||.....||:|||||||..||.:|.....|:..:.|..||.
  Rat   471 EKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLAL 535

  Fly   404 KKPEEF-------DPH---LTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRN 458
            |:.:::       .||   ||..|..||:.|||||||||.|:.|.:||..|:..:..:......:
  Rat   536 KQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGD 600

  Fly   459 ALNQLTVQSKDNVKDTSAKYVFEFKT-----CALLNITSCPVSEANDRFALTLYNPLAHTVNEYV 518
            :...|.::.|...:...:|...|..|     .:|.......:|....|: |.:|||.....:..|
  Rat   601 SAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRY-LVVYNPFEQERHSVV 664

  Fly   519 RIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVEKLD 583
            .:.|..:..:::.:.|..:|   |.:..|..|:: ..|.|.||:.||| ::|.||.:.|.:.:..
  Rat   665 SVRVNSATVKVLSDLGKAVE---VQVSAVWKDMR-TTSQAAYEVAFLA-HLPPLGLKVYKILESQ 724

  Fly   584 ST------------EGNTRS-----KALPKRTSSVTVIGNSHIQLGFDTNGFLSEV--TADGLTR 629
            |:            :|...|     |.:.....::| |.||.:.||||.:|.:.:|  ..|...:
  Rat   725 SSSSHLADYFLYNNDGQAESGIFHMKNMVDSGDAIT-IENSFLTLGFDRSGLMEKVRRKEDNKQQ 788

  Fly   630 LVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPN-ENKIHFATDQVEIEVYKGDLVHEVHQKFNDWI 693
            .:..:||:|  ...|..:    .||||:|.|: :.:.:.:.....:.|.:|.:..:| ..|.:.:
  Rat   789 ELKVQFLWY--GTTNKRD----KSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDV-TCFLEHV 846

  Fly   694 SQVVRVYNKDSYAEFEWLVGP-------IPIDDGIGKEVITRFNSDIASDGIFRTDSNGREMIKR 751
            :..||:|:      .:.:.|.       :.|.....:|::.|.:|.|.:...:.||.||.::..|
  Rat   847 THKVRLYH------IQGIEGQSMEVSNIVDIRSVHNREIVMRISSKINNQNRYYTDLNGYQIQPR 905

  Fly   752 KINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGGSSLKDGSLELMVHRRLLKD 816
            :.      ..|:  .:..|.||::|...::|...|:.:|:.::.|.||:..|.:|:.:.|||::|
  Rat   906 RT------MAKL--PLQANVYPMSTMAYIQDAAHRLTLLSAQSLGASSMASGQIEVFMDRRLMQD 962

  Fly   817 DAFGVGEALNETEYGDGLIARGKHHLFFGKSTDREGVSLKGIERLTQLEKLLPTW--KFFSNMED 879
            |..|:|:.::     |..|......:...|   |.|:::       :.:|..|..  ...|:|
  Rat   963 DNRGLGQGVH-----DNKITANLFRILLEK---RNGMNM-------EEDKKSPVSYPSLLSHM-- 1010

  Fly   880 YSADEWQTAFTN------IFSGISLVLPKPVHLLTLEPWHENQLLVRFEHIMENGEDASYSQPVQ 938
                  .:||.|      :.||   .||.|...|
  Rat  1011 ------TSAFLNHPFLPMVLSG---QLPSPAIEL------------------------------- 1035

  Fly   939 FNVKNVLSAFDVEGIRETTLDGNAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAE--K 1001
                                     |.|.|.||               .|.|.: :||::..  :
  Rat  1036 -------------------------LSEFRLLQ---------------SSLPCD-IHLVNLRTIQ 1059

  Fly  1002 PMLGVKYADEALPAGQLGAESNRIRRETETRQEKKDEGRSSKSTEGP------YNSFKSDS---- 1056
            ..:|..|:|||.....        |:..:.:...:..|....:|:|.      :|:|..:|
  Rat  1060 SKVGKGYSDEAALILH--------RKVFDCQLSSRAMGLPCSTTQGKMSIPKLFNNFAVESFIPS 1116

  Fly  1057 ----------SNQEYIIELSPMEIRT 1072
                      :.....:.||||||.|
  Rat  1117 SLSLMHSPPDAQNTSEVSLSPMEIST 1142

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	240/850 (28%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	98/300 (33%)
Man2a1	NP_037111.2	PLN02701	127..1148	CDD:178304	287/1131 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1121..1148		7/22 (32%)