Protein Alignment LManII and man2a2

DIOPT Version :10

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_009296075.2
• Gene: man2a2 / 100333987
• ZFINID: ZDB-GENE-110331-1
• Length: 1177
• Species: Danio rerio
• Alignment Length: 889
• Identity: 250/889 - (28%)
• Similarity: 388/889 - (43%)
• Gaps: 180/889 - (20%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQYYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFFKW 111
            |.|.:|.|:|:|.||:||.|: ||..:|       |:|::::|..:..||.::||:.|.::|.||
Zfish   166 LQVFVVPHSHNDPGWIKTFDK-YYNDQT-------QHILNNMVTKMAEDPRRKFIWSEISYFAKW 222

  Fly   112 WKEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDTFGECGRPRVG 176
            |:......||.::.|:..|:||.:.|.|.|.|||..||.::|||...|.:.|....|.  .||.|
Zfish   223 WESADVHKQEVMRKLILSGQLEMVTGGWVMTDEANAHYFAMIDQLIEGHQWLERNLGV--TPRSG 285

  Fly   177 WQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGEEADLFSGAL- 240
            |.:||||||..|..:..:.....|...|:.|..|.....|::.|.:|..:.::....|:|...:
Zfish   286 WAVDPFGHSATMPYLLKRANISSMLIQRVHYSIKKHFAATRSLEFMWRQAWDIESSTDMFCHMMP 350

  Fly   241 YNNYQAPDGFCFDILCNDAPII----DGKHSP----------------DNNVKERIDTFLDFAKT 285
            :.:|..|.      .|...|.|    |.|..|                |.||.||....||..:.
Zfish   351 FYSYDVPH------TCGPDPKICCQFDFKRLPGSRVNCPWKVPPRAINDANVAERAGVLLDQYRK 409

  Fly   286 QSQYYRTNNIIVTMGGDFTYQAAQVY---YKNLDKLIRYGNERQANGSNINLLYSTPSCYLKSLH 347
            :|:.:|:..::|.:|.||.|..|..:   |.|..||..|.|....  .::...::|.|.|..:::
Zfish   410 KSKLFRSKVLLVPLGDDFRYDKALEWDQQYLNYQKLFDYMNSHPE--MHVKAQFATLSDYFDAVY 472

  Fly   348 DA-GIT-------WPTKSDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSALA-- 402
            .| |:|       :|..|.|||.||.....||:||:||||..|..:|.....|:..:.|.:||
Zfish   473 KANGVTSGARPPDYPVLSGDFFAYADREDHYWSGYYTSRPFYKNLDRILESHLRGAEILYSLAVA 537

  Fly   403 --------PKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDYAKRMSVAFRACGATTRNA 459
                    .:.|......||..|..:|:.|||||||||.||.|.:||..|:..:.........||
Zfish   538 HARHAGVEGRYPVSDYSLLTDARRNIGLFQHHDAITGTAKEAVVIDYGNRLLRSLVGLKRVIINA 602

  Fly   460 LNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDRFA-------------------LT 505
            .:.|.:::||         ::.|       ..:.|..|.:||.|                   |.
Zfish   603 AHFLIIKNKD---------IYRF-------YQTEPFLETDDRRATQDSLPQRTLIELESSPRYLV 651

  Fly   506 LYNPLAHTVNEYVRIPVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAK----YEIVFLA 566
            |:||:.......|.:.|..:..|::...|.||..|        :..:..::|..    |:..|:|
Zfish   652 LFNPVEQERLCLVTVLVNSARVRVLTEDGQTLPVQ--------LSAQWMSATEMSGEVYQASFMA 708

  Fly   567 TNIPALGYRTYYVEKLDSTEGNTRSKAL---PKRTSSV-----------TVIGNS-HIQ-----L 611
             .:||||...:::.....:....||:.|   |.|..|:           ||.|.. :||     |
Zfish   709 -RLPALGLAVFHLYDSADSPMTLRSETLLRVPGRGQSIRGLDPLPVRSQTVDGQPFYIQTQSLTL 772

  Fly   612 GFD-TNGFLSEVTA--DGLTRLVSQEFLFYEGAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVE 673
            ||. ..|.|..:..  |.....|..:||.|......:      .||||:|.|:.|...::..:..
Zfish   773 GFSGATGLLESIRRKDDPQEVRVQIQFLTYGTRPSKD------KSGAYLFLPDGNAKPYSQRETP 831

  Fly   674 I-EVYKGDLVHEV---HQKFNDWISQVVRVYNKDSYAEFEWLVGPIPIDDGI------------- 721
            | .|.:|.|..||   :|.|    .|.||::|             :|..||:
Zfish   832 IVRVVEGPLFAEVVAHYQHF----QQTVRIHN-------------VPGVDGLSLDITTMVDIRDQ 879

  Fly   722 -GKEVITRFNSDIASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTA 785
             .||:..||.:||.|...|.||.||.::..|:      :..|:  .:..|:||:.:...::|...
Zfish   880 NNKELAMRFVTDIQSGDTFYTDLNGFQIQPRR------YFQKL--PLQANFYPMPSTAYIQDSQY 936

  Fly   786 RMAILTDRAQGGSSLKDGSLELMVHRRLLKDDAFGVGEALNETE 829
            |:.:.|.:|.|.:||..|.||:::.|||::||..|:|:.|.:.:
Zfish   937 RLTLHTAQALGVTSLASGQLEVILDRRLMQDDNRGLGQGLKDNK 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	248/881 (28%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	94/299 (31%)
man2a2	XP_009296075.2	None