Protein Alignment LManII and man2b2

DIOPT Version :10

• Sequence 1: NP_609408.1
• Gene: LManII / 34437
• FlyBaseID: FBgn0027611
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: XP_021333425.1
• Gene: man2b2 / 100003570
• ZFINID: ZDB-GENE-140106-166
• Length: 1006
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 297/1156 - (25%)
• Similarity: 473/1156 - (40%)
• Gaps: 299/1156 - (25%)

  Fly    47 LNVHLVAHTHDDVGWLKTVDQ--YYYGSETKIQKAGVQYIIDSVVEALLRDPEKRFIYVESAFFF 109
            :...::.|:|.||||:.||.:  :.|.|.          :..:|||.|.|...::||.||..||.
Zfish    23 IQAFVIPHSHMDVGWVYTVQESMHAYASN----------VYSTVVEELTRVKNRKFIAVEQEFFR 77

  Fly   110 KWW--------KEQKPKVQEAVKMLVEQGRLEFIGGAWSMNDEATTHYQSVIDQFSWGLRLLNDT 166
            .||        |:|       |:.|:.:||||||.|...|:|||.|.....|.|.:.|...|.:|
Zfish    78 LWWTNVASDWHKKQ-------VRQLLLEGRLEFIIGGQVMHDEAVTDVDDAILQLTEGHGFLYET 135

  Fly   167 FGECGRPRVGWQIDPFGHSREMASMFAQMGFDGMFFGRLDYQDKDERLMTKNAEMIWHGSANLGE 231
            ||.  |||..|.:||||.|.....:||..|||.....|:||..||:....|..:.:|.||..|.|
Zfish   136 FGV--RPRFAWHVDPFGASATTPVLFALAGFDAHLISRIDYDLKDDMQKNKKLQFVWRGSPTLKE 198

  Fly   232 EADLFSGAL---------YNNYQAPDGFCFD--ILCNDAPIIDGKHSPDNNV---KERID----T 278
            :.::|:..:         |..:....||.::  .|..|.| .|||: |:.::   ||.::    |
Zfish   199 KQEIFTHTMDQFSYCTPSYIPFSNRSGFYWNGVALFPDPP-KDGKY-PNMSLPVTKETVELYAQT 261

  Fly   279 FLDFAKTQSQYYRTNNIIVTMGGDFTYQAAQVYYKNLDKLIRYGNERQANGSNINLLYSTPSCYL 343
            .:|..:.::|::|:::::...|.|..:..|.|.:.|:|.|:.|.| ..::...:.:.|:|...|.
Zfish   262 MVDNIRLRAQWFRSSHVLWPWGCDKQFYNASVQFSNMDVLMNYIN-THSDQYGVTVQYATLKDYF 325

  Fly   344 KSLHDAGITWPTK-SDDFFPYASDPHAYWTGYFTSRPTLKRFERDGNHFLQVCKQLSAL------ 401
            ::||...::|..: :.||.||:::|...|||::.||..||...|..:..|...:.|...
Zfish   326 QTLHQTNLSWDVRGNQDFLPYSTEPFQAWTGFYGSRNVLKGVARRASSLLYASESLFTRYHISYP 390

  Fly   402 -APKKPEEFDPHLTFMRETLGIMQHHDAITGTEKEKVALDY----------AKRMSVAFRACGAT 455
             .|.:.|.....|..:|..:..:||||.|||||..|||..|          |:.:..|......|
Zfish   391 DGPVQREWALSKLKALRWAVSEVQHHDGITGTESPKVADMYMEHLLQGMMGAEELLAAIFLLPQT 455

  Fly   456 TRNALNQLTVQSKDNVKDTSAKYVFEFKTCALLNITSCPVSEANDRFALTLYNPLAHTVNEYVRI 520
            ..|.:       .|.:|:|        .|.|..:..:.|...      :.:|||||..::.||.:
Zfish   456 LSNDI-------YDQIKNT--------PTTARTDSENVPEQH------IFVYNPLAWNISTYVNV 499

  Fly   521 PVPYSNYRIIDNKGVTLESQAVPIPQVLIDIKHRNSTAKYEIVFLATNIPALGYRTYYVE----- 580
            .|.|:...::|:.|..:.:|..|         ...|:..|:: |....:..|.||.|.|:
Zfish   500 SVQYAMAVVLDDDGKAVPAQIQP---------SMESSTVYDL-FFVVELGGLQYRKYTVQFPQSP 554

  Fly   581 ----------------KLDSTE----GNTRSKALPKRTSSVTVIGNSHIQLGFDTNGFLSEVTAD 625
                            |.:.|.    ..|..|.||        :.|...:|.||....|.....|
Zfish   555 CDTGSACGATHVAKVVKFNKTNVRQWKKTGRKLLP--------VLNECYKLMFDQETNLLHSITD 611

  Fly   626 GLTRL---VSQEFLFYE-------GAVGNNAEFLNRSSGAYIFRPNENKIHFATDQVEIEVYKGD 680
            ...::   |.|:|..|:       |.:.:|          |||..|.:.:. |...|.:|:..|.
Zfish   612 RSKKIRVRVQQDFWEYKANGDVQSGPISDN----------YIFTANGSAVP-AYKSVVMEIVPGK 665

  Fly   681 LVHEVHQKF-------NDWISQVVRV----YNKDSYAEFE--WLVGPIPIDDGIGKEVITRFNSD 732
            ::.|:.|.|       |...|.|.||    ..:.|....|  :.|||:.::    :|.:.|..:.
Zfish   666 VISEIRQYFYREEEDANHTYSVVTRVPVGFKGRLSCFRLEQSYKVGPLEVN----RETVFRTRTS 726

  Fly   733 IASDGIFRTDSNGREMIKRKINHRDTWSVKINEAVAGNYYPITTKIDVEDDTARMAILTDRAQGG 797
            :.::....||:||.:|:||      |:....|..||.||||:.....:||:::|:..|::||.|.
Zfish   727 LQNNRTLFTDNNGYQMMKR------TYKGYANNTVARNYYPMVRVAYMEDESSRVVFLSERAHGV 785

  Fly   798 SSLKDGSLELMVHRRLLKDDAFGVGEALNETEYGDGLIARGKHHLFFGKSTD-------REGVSL 855
            :||..|.||:|:||||..:..:..|..|.   ..|..:.|....:..| |.|       :|.|.|
Zfish   786 ASLSQGQLEVMLHRRLWNNQEWNQGYNLT---LNDSSVVRPVLWMMLG-SPDSLSSIYQQEAVEL 846

  Fly   856 KG---IERLTQLEKLLPTWKFFSNMEDYSADEWQTAFTNIFSGIS---LVLPKPVHLLTL----- 909
            :.   :..:.|.:|||       |..:            .|||.|   :|||:.:|:.:|
Zfish   847 QHRPVVMAIDQPQKLL-------NQRE------------TFSGPSVHPVVLPQNLHMQSLSIPGW 892

  Fly   910 --EPWHE-----------NQLLVRFEHIMENGEDASYSQPVQFNVKNVLSAF-DVEGIRETTLDG 960
              .|.|.           :::|:|..|:.|.||....|||...|:|.|:... .|..::|.:|.|
Zfish   893 NYSPEHSSGGDEKSEVNFDRILLRITHLYEEGESPVLSQPTTINLKEVMQGIGKVSKVQECSLTG 957

  Fly   961 NAWLDESRRLQFAPDPEEAAFNTYATFSQPAESVHLLSAEKPMLGVKYADEALPAGQLGAESNRI 1025
            ...:.:.:|..:..|
Zfish   958 TWNISDLQRWNWKTD-------------------------------------------------- 972

  Fly  1026 RRETETRQEKKDEGRSSKSTEGPYNSFKSDSSNQEYIIELSPMEIRTFIVY 1076
                ||.|:....|.|..:              |::.:.:||.|||||.:|
Zfish   973 ----ETMQKTDKSGFSGVT--------------QDFNVTISPKEIRTFFIY 1005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LManII	NP_609408.1	PLN02701	47..823	CDD:178304	239/869 (28%)
		GH38N_AMII_LAM_like	47..323	CDD:212121	96/303 (32%)
man2b2	XP_021333425.1	PLN02701	20..1002	CDD:178304	294/1151 (26%)
		GH38-57_N_LamB_YdjC_SF	23..348	CDD:483946	107/346 (31%)