DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LManI and LManIV

DIOPT Version :9

Sequence 1:	NP_001260350.1	Gene:	LManI / 34436	FlyBaseID:	FBgn0032253	Length:	950	Species:	Drosophila melanogaster
Sequence 2:	NP_609251.2	Gene:	LManIV / 34204	FlyBaseID:	FBgn0032067	Length:	978	Species:	Drosophila melanogaster

Alignment Length:	951	Identity:	596/951 - (62%)
Similarity:	736/951 - (77%)	Gaps:	18/951 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MINVHLVPHSHDDVGWLKTVDQYYYGSQNKIQHAGVQYILDTVVEELLKDSSRRFIQVETFFFAK 65
            |:|:|||||||:||||||||||.|||.:|||.|||||||||:||.:||:|..||||||||.||||
  Fly    37 MVNIHLVPHSHNDVGWLKTVDQSYYGYKNKIHHAGVQYILDSVVSQLLQDPKRRFIQVETAFFAK 101

  Fly    66 WYSEQTETVQRAVKKLVAQGRLEFAGGAWSMNDEATVHYQSVVDQFNLGLRYLKDTFGDCGRPTV 130
            |::.|:|::::.|.|||.:||.||.||||||||||.|:||.|:|||.:||::|.:|||.||||.|
  Fly   102 WWNVQSESMKKVVTKLVNEGRFEFTGGAWSMNDEANVNYQGVIDQFTVGLKFLNETFGSCGRPRV 166

  Fly   131 GWQIDPFGHSREMASIFAQMAFNGEFFARMDYVDKKQRMLDLEMEMIWQSSESLKNSNIFTGMLY 195
            |||||.||||||.|:|||.|.::|:||:|||:.||..||.||.|||||.:|||:...::|:||||
  Fly   167 GWQIDTFGHSREQAAIFAHMGYDGQFFSRMDHNDKDTRMNDLTMEMIWDASESMSGVSLFSGMLY 231

  Fly   196 NHYSAPPGFCFDINCEDAPIIDGESYDNNVDARVSEFIDYVKNMSKSYRSTHIMVPMGDDFQYED 260
            |.||..|||||||.|.|.|||||:|.:|||..||.:||.|.||:|:.|.:.|||||||.||||||
  Fly   232 NFYSDTPGFCFDILCTDQPIIDGDSEENNVKQRVDDFISYAKNVSEVYITNHIMVPMGGDFQYED 296

  Fly   261 AAVNFKNMDKLIKYVNDRQSTGSQVNVFYSTPSCYLYELHQLKQTWPNKTEDFFPYSSDSHSYWT 325
            |.||:|||||||||:|:||::||:.|:|||||||||..|||..::|||||:|||||:.:.:|:||
  Fly   297 AKVNYKNMDKLIKYINERQASGSKYNIFYSTPSCYLNSLHQSLESWPNKTQDFFPYAHEKNSFWT 361

  Fly   326 GYFTSRPTQKRFHRDGNHFFQTVKQLSVLANLSGTQYSEDLDNLSQAMGIMQHHDAVTGTEKQAV 390
            |:||||||||||.|||||..|..|||||||||:..::..|||.|.|.||:||||||:||||||||
  Fly   362 GFFTSRPTQKRFERDGNHMLQVAKQLSVLANLTSEEHKIDLDYLRQVMGVMQHHDAITGTEKQAV 426

  Fly   391 ASDYDRLLFKAIVGAENSARDALRSLTNLTSGEFESCLELNISVCAFTQDTANNVIVTLVNPLAH 455
            :.||||::::|||||.|:||||||.|||:..|||||||.||||.||||:|.|:||:|||.|||||
  Fly   427 SDDYDRMMYEAIVGASNNARDALRLLTNMPYGEFESCLRLNISECAFTKDGADNVLVTLYNPLAH 491

  Fly   456 SSTQYVRVPAKNENYIVTDEKGREVFSEVVPVPWQVLALEHRPNDTQHELVFEASVDKIANFLIR 520
            |||||||:|.|.|||.|||||||.|.||||||||||||||:|.|||||||||:|:|:|::::.|:
  Fly   492 SSTQYVRIPVKEENYQVTDEKGRTVPSEVVPVPWQVLALEYRSNDTQHELVFKATVNKVSSYSIK 556

  Fly   521 VLPSP--KNIAEDQVQFPVERSQDELTVETSLVKLTFDTTTGGLKTVKMNGFTENIQQTFGIYKG 583
            .:.|.  |:.:..::. |.|.:..|..||.|:|||..|..||.||:|:|||.:|.|.|.||:||.
  Fly   557 KVESSEVKHSSIKKIN-PREDNNSETVVENSVVKLVMDNHTGRLKSVEMNGVSEKIVQNFGVYKS 620

  Fly   584 YRGNNGESKNRSSGAYVFRPYGDIEIVNNKVELSFYNGTKVKEVHQHVNEWISQVIRIYEDVNRV 648
            :          :|.||.||..||||:..|..|.:.|.|:.|||||||||:||||||||||.|:||
  Fly   621 H----------TSCAYTFRQDGDIELFENDFEFTVYEGSLVKEVHQHVNDWISQVIRIYEGVSRV 675

  Fly   649 EFEWLVGPIPTDDDVGKEIITRFSSNISSKGKFYTDSNGREILERERNQREHFTPDMS-EAISGN 712
            |.||:|||||.||.:|.|.:|.|.|.|||.|.|||||||||:::|.:::||.|..|:| :.:|||
  Fly   676 ELEWMVGPIPIDDKLGSEFVTNFKSEISSNGVFYTDSNGRELMKRVKDKREDFVSDLSRQPVSGN 740

  Fly   713 YYPVTGQISLQDDEKRITLLNDRAQGGTSLKDGELELMLHRRLLNDDAFGVGEALNETQYGTGLI 777
            :||||.:|:||||.||:.|||||:|||.||:||.||:::|||.|.:|..||||||||||||.|||
  Fly   741 FYPVTSRIALQDDTKRLVLLNDRSQGGASLEDGALEMLIHRRHLFNDGGGVGEALNETQYGKGLI 805

  Fly   778 ARGKIYLILD-AVDGKP-NQRLLQHQLDQHFWKFFSKSNGVASVNRNMIPDFFGIPESVELLSLE 840
            ||||:||||| |.||.. .:|..:.:|...|||||||:.||.......:|||..:|:||.||:||
  Fly   806 ARGKLYLILDSATDGDTVTERKTEKELFLPFWKFFSKTGGVEITPSKSLPDFNDLPQSVHLLTLE 870

  Fly   841 PYSKDQILIRLENF--NTEGNVVSFNIYPLFESLDGYQIWETTLDGNMLLEDVKRFKFAQDGTGS 903
            .:|:.:||||.|:|  .:||.|:||||..:|:||.|..|.||||||||.|.|:|||||....:|:
  Fly   871 FFSEQEILIRFEHFLDKSEGRVISFNIRDIFDSLGGLAIRETTLDGNMPLSDMKRFKFHAQESGT 935

  Fly   904 IPSSVEYYHAPHNPLTANSTMNASGFVVTLVPMQIRTFIIQ 944
            .||||||..|.|.||.|..:..||.|.|||.|||||||||:
  Fly   936 KPSSVEYSTAQHKPLEAVKSDEASLFAVTLYPMQIRTFIIK 976

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LManI	NP_001260350.1	GH38N_AMII_LAM_like	2..276	CDD:212121	185/273 (68%)
		Alpha-mann_mid	323..398	CDD:286360	53/74 (72%)
		Glyco_hydro_38C	536..941	CDD:285047	232/409 (57%)
LManIV	NP_609251.2	GH38N_AMII_LAM_like	39..312	CDD:212121	185/272 (68%)
		Alpha-mann_mid	359..434	CDD:214875	53/74 (72%)
		Glyco_hydro_38C	483..973	CDD:285047	290/500 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450122
Domainoid	1	1.000	310	1.000	Domainoid score	I311
eggNOG	1	0.900	-	-		E1_KOG1959
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	649	1.000	Inparanoid score	I170
Isobase	1	0.950	-	0	Normalized mean entropy	S4230
OMA	1	1.010	-	-		QHG55625
OrthoDB	1	1.010	-	-		D201312at2759
OrthoFinder	1	1.000	-	-		FOG0001724
OrthoInspector	1	1.000	-	-		otm24899
orthoMCL	1	0.900	-	-		OOG6_101099
Panther	1	1.100	-	-	P	PTHR11607
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1279
	13	12.760