DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdfy2 and Fbxw11

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_598776.1	Gene:	Fbxw11 / 103583	MGIID:	2144023	Length:	563	Species:	Mus musculus

Alignment Length:	295	Identity:	63/295 - (21%)
Similarity:	118/295 - (40%)	Gaps:	52/295 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ENGVISVSDDKTVRVW-------LKRDSGQYWPSICQYMPSGCTAIEYVSESRHLYVGQENGTVT 101
            ::.:||...|.::::|       ||..:|.....:|         ::|  :.|.:..|..:.||.
Mouse   271 DDKIISGLRDNSIKIWDKSSLECLKVLTGHTGSVLC---------LQY--DERVIVTGSSDSTVR 324

  Fly   102 QYALSEDCNRLSFLRDYLSHQARVMAVVFSKTHKWILSAGKDKQFAY----HCTESGKRVGGYNF 162
            .:    |.|....|...:.|...|:.:.||  :..:::..||:..|.    ..|:...|......
Mouse   325 VW----DVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGH 383

  Fly   163 ETPCTALQFDALAKYAFVGDHAGQITMLRCDVQGVQLITTFNGHSAEIRCLKWVEGPQLLFSGAC 227
            ......:.||  .||  :...:|..|:........:.:.|.|||...|.||::.:  :|:.||:.
Mouse   384 RAAVNVVDFD--DKY--IVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSS 442

  Fly   228 DQSVLVWDV--GGKRGTIYELQGHSNKVSALSYANHTQQLISCGEDSVVVFWEMN-AMRKEVPGW 289
            |.::.:||:  |   ..:..|:||...|..:.:.|  ::::|...|..:..|::. |:....|.
Mouse   443 DNTIRLWDIECG---ACLRVLEGHEELVRCIRFDN--KRIVSGAYDGKIKVWDLQAALDPRAPA- 501

  Fly   290 VDTNNCQLCSRPFFWN----FRSMMDQKQLGIRQH 320
                 ..||.|....:    ||...|:.|:....|
Mouse   502 -----STLCLRTLVEHSGRVFRLQFDEFQIISSSH 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	63/295 (21%)
		WD40	24..279	CDD:295369	53/247 (21%)
		WD40 repeat	35..72	CDD:293791	7/34 (21%)
		WD40 repeat	80..117	CDD:293791	8/36 (22%)
		WD40 repeat	125..161	CDD:293791	8/39 (21%)
		WD40 repeat	166..205	CDD:293791	7/38 (18%)
		WD40 repeat	211..248	CDD:293791	10/38 (26%)
		WD40 repeat	253..283	CDD:293791	6/30 (20%)
		FYVE_WDFY1_like	287..356	CDD:277258	9/38 (24%)
		WD40 repeat	324..371	CDD:293791
Fbxw11	NP_598776.1	Beta-TrCP_D	99..137	CDD:403372
		F-box-like	141..188	CDD:403981
		WD40	261..539	CDD:238121	63/295 (21%)
		WD40 repeat	264..299	CDD:293791	6/27 (22%)
		WD40 repeat	305..339	CDD:293791	9/48 (19%)
		WD40 repeat	344..381	CDD:293791	8/38 (21%)
		WD40 repeat	388..421	CDD:293791	7/36 (19%)
		WD40 repeat	427..461	CDD:293791	10/38 (26%)
		WD40 repeat	467..510	CDD:293791	10/50 (20%)
		WD40 repeat	516..538	CDD:293791	5/16 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910