DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdfy2 and KATNB1

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_005877.2	Gene:	KATNB1 / 10300	HGNCID:	6217	Length:	655	Species:	Homo sapiens

Alignment Length:	188	Identity:	43/188 - (22%)
Similarity:	86/188 - (45%)	Gaps:	27/188 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 LRDYLSHQARVMAVVFSKTHKWILSAGKDKQFAYHCTESGKRVGGYNFE------------TPCT 167
            |::.::|.:.|.::|..|....:|:.|.|     .|     ||..::..            :|..
Human    13 LQEIVAHASNVSSLVLGKASGRLLATGGD-----DC-----RVNLWSINKPNCIMSLTGHTSPVE 67

  Fly   168 ALQFDALAKYAFVGDHAGQITMLRCDVQGVQLITTFNGHSAEIRCLKWVEGPQLLFSGACDQSVL 232
            :::.:...:....|..:|.|.:  .|::..:::.|..||.|.|..|.:....:.:.||:.|.::.
Human    68 SVRLNTPEELIVAGSQSGSIRV--WDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130

  Fly   233 VWDVGGKRGTIYELQGHSNKVSALSYANHTQQLISCGEDSVVVFWEMNA--MRKEVPG 288
            :||: .::|.::..:|||..|..|.::...:.|.|..:|..|..|::.|  |..|.||
Human   131 LWDI-RRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	43/188 (23%)
		WD40	24..279	CDD:295369	38/175 (22%)
		WD40 repeat	35..72	CDD:293791
		WD40 repeat	80..117	CDD:293791	1/1 (100%)
		WD40 repeat	125..161	CDD:293791	9/35 (26%)
		WD40 repeat	166..205	CDD:293791	5/38 (13%)
		WD40 repeat	211..248	CDD:293791	7/36 (19%)
		WD40 repeat	253..283	CDD:293791	8/31 (26%)
		FYVE_WDFY1_like	287..356	CDD:277258	2/2 (100%)
		WD40 repeat	324..371	CDD:293791
KATNB1	NP_005877.2	Interaction with centrosomes	1..300		43/188 (23%)
		Interaction with dynein. /evidence=ECO:0000250	1..284		43/188 (23%)
		WD40	7..257	CDD:238121	43/188 (23%)
		WD40 repeat	67..103	CDD:293791	5/37 (14%)
		WD40 repeat	108..144	CDD:293791	8/36 (22%)
		WD40 repeat	151..186	CDD:293791	9/34 (26%)
		WD40 repeat	192..228	CDD:293791
		WD40 repeat	234..261	CDD:293791
		Interaction with PAFAH1B1. /evidence=ECO:0000250	285..434
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..422
		DNA_pol3_gamma3	<386..>494	CDD:331207
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000250	433..655
		Katanin_con80	497..648	CDD:316447
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910