DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Wdfy2 and TOM1L1

DIOPT Version :9

Sequence 1:	NP_001188779.1	Gene:	Wdfy2 / 34425	FlyBaseID:	FBgn0032246	Length:	408	Species:	Drosophila melanogaster
Sequence 2:	NP_005477.2	Gene:	TOM1L1 / 10040	HGNCID:	11983	Length:	476	Species:	Homo sapiens

Alignment Length:	128	Identity:	28/128 - (21%)
Similarity:	46/128 - (35%)	Gaps:	31/128 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GENGVISVSDDKTVRVWLKRDSGQYWPS-------------ICQYMPSGCTAIEYVSESRHLYVG 94
            |..|.:.||:.|.|.:.|.:...|:.||             |....|:.......:|.    .:.
Human   129 GFPGGVDVSEVKEVYLDLVKKGVQFPPSEAEAETARQETAQISSNPPTSVPTAPALSS----VIA 189

  Fly    95 QENGTVTQYALSEDCNRLSFLRDYLSHQARVMAVVF------SKTHKWI------LSAGKDKQ 145
            .:|.|||  .:.|...:|....|.:....|||:.:.      |:.|:.|      ...|::.|
Human   190 PKNSTVT--LVPEQIGKLHSELDMVKMNVRVMSAILMENTPGSENHEDIELLQKLYKTGREMQ 250

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Wdfy2	NP_001188779.1	WD40	4..405	CDD:225201	28/128 (22%)
		WD40	24..279	CDD:295369	28/128 (22%)
		WD40 repeat	35..72	CDD:293791	10/41 (24%)
		WD40 repeat	80..117	CDD:293791	7/36 (19%)
		WD40 repeat	125..161	CDD:293791	7/33 (21%)
		WD40 repeat	166..205	CDD:293791
		WD40 repeat	211..248	CDD:293791
		WD40 repeat	253..283	CDD:293791
		FYVE_WDFY1_like	287..356	CDD:277258
		WD40 repeat	324..371	CDD:293791
TOM1L1	NP_005477.2	VHS_Tom1	14..154	CDD:239623	8/24 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	155..179		4/23 (17%)
		GAT_TM1L1	199..290	CDD:260095	11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..327
		Interaction with GRB2. /evidence=ECO:0000250	392..395
		SH3-binding. /evidence=ECO:0000250	421..425
		Interaction with PIK3R1. /evidence=ECO:0000250	442..445
		SH2-binding. /evidence=ECO:0000250	460..463
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141212
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930