Protein Alignment da and Tcf12

DIOPT Version :10

• Sequence 1: NP_001356956.1
• Gene: da / 34413
• FlyBaseID: FBgn0267821
• Length: 775
• Species: Drosophila melanogaster
• Sequence 2: NP_037308.1
• Gene: Tcf12 / 25720
• RGDID: 3829
• Length: 707
• Species: Rattus norvegicus
• Alignment Length: 757
• Identity: 230/757 - (30%)
• Similarity: 319/757 - (42%)
• Gaps: 238/757 - (31%)

  Fly    26 QPTGTVGADRGGGGGYHSPYGS-------LGVENGMYPSDFNSMHDTVNGGNNRYANASTVDQYF 83
            ||:.:..:.|   |...||:.|       ||...|:.|:.|  |:..:.|..:...:.|...:
  Rat    65 QPSPSYDSSR---GFTDSPHYSDHLNDSRLGTHEGLSPTPF--MNSNLIGKTSERGSFSLYSR-- 122

  Fly    84 DSAAAGSGGAWCQPQMSSANSYMGQSAYQNSGPLSG------HSIDQQQQQVHQADGLGMGGGGG 142
            ||..:|     ||..:...:..:|..|..:|....|      .:...:::.:|.:
  Rat   123 DSGLSG-----CQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDS---------- 172

  Fly   143 GGVGADGMHC----PVTTGL-------------------------PPISSFRPT----------- 167
              |..|.:..    .|..||                         ||.|.|..|
  Rat   173 --VALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSS 235

  Fly   168 -----SGGIGGPGAGQQAPVNVNVNPPAVFNSPQAHNHNHTVQAQHSALSTAGPL-GHHSLNHTP 226
                 |.|:..||.|            .:..:..:|         .|..|:.|.| .|..|::.|
  Rat   236 DLWSSSNGMSQPGFG------------GILGTSTSH---------MSQSSSYGSLHSHDRLSYPP 279

  Fly   227 HAHSHT-----LPLPHALPHGHTLPHPHHSQQNSPAVQSSDAFSGA-GASVKVAGAGNSSAAALR 285
            |:.|.|     ||...:...|.|...|:.:..::|.:..||:..|. |.:...:..|::...||
  Rat   280 HSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKAL- 343

  Fly   286 QQMYMPADQSISSFGSNPSTPVNSPPPLTQSVVGGGGEPSVSGGSGWGHSVLNGG--PSS-SYAS 347
            ..:|.| |.:.|||.|||||||.||.|||            :|.|.|..:   ||  ||| ||.
  Rat   344 ASIYSP-DHTSSSFPSNPSTPVGSPSPLT------------AGTSQWPRA---GGQAPSSPSYE- 391

  Fly   348 EMVPVSSLHTMAS-------------------VFQGVRME---ERLDDALNVLRNHCEPEMLAGV 390
                 :|||::.:                   |.:..|||   :|||||::|||||.     .|.
  Rat   392 -----NSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLRNHA-----VGP 446

  Fly   391 NQSL-ASIDNIDALTSFVPNSP-SHLGSG-GNSGSVSNTSNAALV-------------HEVLALG 439
            :.|| .|..:|.:|.....|:| .:|.|. |.|..|:|:.:|::|             |.||:..
  Rat   447 STSLPTSHSDIHSLLGPSHNAPIGNLNSNYGGSSLVTNSRSASMVGTHREDSVSLNGNHSVLSST 511

  Fly   440 AAAA-------------AGTSGQSVGGAGSLASLKLDRSASTSLPKQTKKRKEHTAISNSVPAGV 491
            .||:             .|...||    ||:        ..|.:..:.|::.|:.   :..|:.
  Rat   512 VAASNTELNHKTPESFRGGVQNQS----GSV--------VPTEIKTENKEKDENL---HEPPSS- 560

  Fly   492 STTSSLTSLDISDTKPTSSIESSNSGLQQHSQGKGTKRPRRYCSSADEDDDAEPAVKAIREKERR 556
                       .|.|  |..|||...::..|:|:        .||.:||:|..|..|..||||||
  Rat   561 -----------DDMK--SDDESSQKDIKVSSRGR--------TSSTNEDEDLNPEQKIEREKERR 604

  Fly   557 QANNARERIRIRDINEALKELGRMCMTHLKSDKPQTKLGILNMAVEVIMTLEQQVRERNLNPKAA 621
            .|||||||:|:||||||.|||||||..||||:||||||.||:.||.||::|||||||||||||||
  Rat   605 MANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAA 669

  Fly   622 CLKRREEEKAEDGPKLSAQHHMIPQPQQVGGT-PGSSYHSQP 662
            |||||||||..   ..||:     .|..:.|| ||.|..:.|
  Rat   670 CLKRREEEKVS---AASAE-----PPTTLPGTHPGLSETTNP 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
da	NP_001356956.1	bHLH_E-protein_Da_like	554..623	CDD:381473	55/68 (81%)
Tcf12	NP_037308.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	25..109		13/48 (27%)
		Leucine-zipper	119..140		5/27 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	140..222		13/93 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..313		17/84 (20%)
		CytochromB561_N	275..>411	CDD:480696	49/158 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	349..393		27/65 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	521..605		29/120 (24%)
		bHLH_E-protein_TCF4_E2-2	596..680	CDD:381515	68/83 (82%)
		Class A specific domain	657..680		22/22 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	675..707		13/37 (35%)