DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk1 and Pak5

DIOPT Version :9

Sequence 1:	NP_476797.1	Gene:	Cdk1 / 34411	FlyBaseID:	FBgn0004106	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	XP_006499571.1	Gene:	Pak5 / 241656	MGIID:	1920334	Length:	736	Species:	Mus musculus

Alignment Length:	285	Identity:	72/285 - (25%)
Similarity:	135/285 - (47%)	Gaps:	32/285 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 EDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVCL 66
            |..:...|||||:.|:|.....:.||:.||:||:.|.....  ......|:.::::..|:|:|.:
Mouse   464 EYLDNFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQR--RELLFNEVVIMRDYHHDNVVDM 526

  Fly    67 EDVLMEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCHRRRVLHRDLKP 131
            .:..:..:.::::.|||....   :..:.....|..|.:.:....:..|:.:.|.:.|:|||:|.
Mouse   527 YNSYLVGDELWVVMEFLEGGA---LTDIVTHTRMNEEQIATVCLSVLKALSYLHNQGVIHRDIKS 588

  Fly   132 QNLLIDKSGLIKVADFGLGRSFGIPVRIYTHEIVTLWYRAPEVLLGSPRYSCPVDIWSIGCIFAE 196
            .::|:...|.||::|||........|......:.|.::.||||:...| |...|||||:|.:..|
Mouse   589 DSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLP-YGTEVDIWSLGIMVIE 652

  Fly   197 MATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQLTNQLKNLDANGI 261
            |...:|.:..:..: |..|..|      :.:.|.|..|            :::::.|:..    :
Mouse   653 MIDGEPPYFNEPPL-QAMRRIR------DSLPPRVKDL------------HKVSSMLRGF----L 694

  Fly   262 DLIQKMLIYDPVHRISAKDILEHPY 286
            ||   ||:.:|..|.:|:::|.||:
Mouse   695 DL---MLVREPSQRATAQELLGHPF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	71/284 (25%)
Pak5	XP_006499571.1	CRIB_PAK_like	26..72	CDD:238526
Pak5	XP_006499571.1	STKc_PAK5	443..734	CDD:132989	72/285 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910