DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk1 and Cdk12

DIOPT Version :9

Sequence 1:	NP_476797.1	Gene:	Cdk1 / 34411	FlyBaseID:	FBgn0004106	Length:	297	Species:	Drosophila melanogaster
Sequence 2:	NP_001029039.1	Gene:	Cdk12 / 192350	RGDID:	621111	Length:	1484	Species:	Rattus norvegicus

Alignment Length:	301	Identity:	114/301 - (37%)
Similarity:	188/301 - (62%)	Gaps:	20/301 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEDFEKIEKIGEGTYGVVYKGRNRLTGQIVAMKKIRLESDDEGVPSTAIREISLLKELKHENIVC 65
            ::.|:.|..|||||||.|||.:::.||::||:||:||:::.||.|.||||||.:|::|.|:::|.
  Rat   720 VDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVN 784

  Fly    66 LEDVL----------MEENRIYLIFEFLSMDLKKYMDSLPVDKHMESELVRSYLYQITSAILFCH 120
            :::::          .::...||:||::..||...::|..|  |...:.::|::.|:...:.:||
  Rat   785 MKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLV--HFSEDHIKSFMKQLMEGLDYCH 847

  Fly   121 RRRVLHRDLKPQNLLIDKSGLIKVADFGLGRSFGI-PVRIYTHEIVTLWYRAPEVLLGSPRYSCP 184
            ::..||||:|..|:|::.||.||:|||||.|.:.. ..|.||::::|||||.||:|||..||:..
  Rat   848 KKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPA 912

  Fly   185 VDIWSIGCIFAEMATRKPLFQGDSEIDQLFRMFRILKTPTEDIWPGVTSLPDYKNTFPCWSTNQL 249
            :|:||.|||..|:.|:||:||.:.|:.||..:.|:..:|...:||.|..|| |.||..  ...|.
  Rat   913 IDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLP-YFNTMK--PKKQY 974

  Fly   250 TNQLKN----LDANGIDLIQKMLIYDPVHRISAKDILEHPY 286
            ..:|:.    :.:..:||:..||..||..|.:|:..|:..:
  Rat   975 RRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDF 1015

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk1	NP_476797.1	STKc_CDK1_euk	3..287	CDD:270845	114/299 (38%)
Cdk12	NP_001029039.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..462
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	485..603
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	616..699
		STKc_CDK12	715..1016	CDD:270847	114/301 (38%)
		S_TKc	723..1016	CDD:214567	114/298 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1046..1101
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1156..1199
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1218..1356
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1484
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910