DRSC/TRiP Functional Genomics Resources

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Protein Alignment CtsL4 and ctsz

DIOPT Version :10

Sequence 1:NP_609387.1 Gene:CtsL4 / 34401 FlyBaseID:FBgn0032228 Length:338 Species:Drosophila melanogaster
Sequence 2:NP_001106427.1 Gene:ctsz / 100127597 XenbaseID:XB-GENE-959211 Length:296 Species:Xenopus tropicalis


Alignment Length:227 Identity:69/227 - (30%)
Similarity:105/227 - (46%) Gaps:39/227 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 MANVPESLDWRS---KGFITPPYNQ---LSCGSCYAFSIAESIMGQV-FKRTGKILS--LSKQQI 179
            ::.:|:..|||:   ..:::...||   ..||||:|.....::..:: .||.|...|  ||.|.:
 Frog    50 VSELPKVWDWRNLNGTNYVSTTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGVWPSAYLSVQHV 114

  Fly   180 VDCSVSHGNQG-CVGGSLRNTLSYLQSTGGIMRDQDYPYVARKGKCQ----------FVPDLSVV 233
            :||:    |.| |.||.......|..| .||..:....|.||..||.          |.....:.
 Frog   115 IDCA----NAGSCEGGDHGGVWEYANS-HGIPDETCNNYQARDQKCDKFNQCGTCVTFGKCFYLS 174

  Fly   234 NVTSWAI---LPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDD--PLCSSASVNHAMV 293
            |.|.|.:   ..|...:.:.|.:...||::..|.|:.| ...|:.|:|.:  |   ||.:||.:.
 Frog   175 NYTLWKVGDFGSVSGREKMMAEIYKNGPISCGIMATEK-LDAYTGGLYAEYQP---SAMINHIVS 235

  Fly   294 VIGFGKD-----YWILKNWWGQNWGENGYIRI 320
            |.|:|.|     |||::|.||:.|||.|::||
 Frog   236 VAGWGLDESGAEYWIVRNSWGEPWGERGWLRI 267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CtsL4NP_609387.1 Inhibitor_I29 36..96 CDD:462410
Peptidase_C1A 128..336 CDD:239068 69/223 (31%)
ctszNP_001106427.1 Peptidase_C1A_CathepsinX 53..294 CDD:239149 69/224 (31%)
Blue background indicates that the domain is not in the aligned region.

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