DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdk5alpha and CDK5R2

DIOPT Version :9

Sequence 1:	NP_001260320.1	Gene:	Cdk5alpha / 34385	FlyBaseID:	FBgn0027491	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_003927.1	Gene:	CDK5R2 / 8941	HGNCID:	1776	Length:	367	Species:	Homo sapiens

Alignment Length:	338	Identity:	128/338 - (37%)
Similarity:	173/338 - (51%)	Gaps:	65/338 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 EKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHC 194
            |..||:.|:.|:||:||:|..:..||| :...|....|             ||:.
Human    51 ESRLKRPSVLISALTWKRLVAASAKKK-KGSKKVTPKP-------------ASTG---------- 91

  Fly   195 NRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMTGPPGKS--QNPS 257
                            |.|...|...:|. ..:.::........:.:...|.|.|...:  :.||
Human    92 ----------------PDPLVQQRNRENL-LRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPS 139

  Fly   258 ----KAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQASTSELL 318
                .|:.|.....|..                 |....|..:........||:.::||||.|||
Human   140 GGSAAAQPPGSGGGKPP-----------------PPPPPAPQVAPPVPGGSPRRVIVQASTGELL 187

  Fly   319 KCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELVSGEE- 382
            :|||.|:..||.||.....|:.|.|.|.||||||||||||.|||.|||:||||:|.||.:.|:|
Human   188 RCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDEL 252

  Fly   383 SKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKINAEPGF 447
            :..::|||:.||||||:||||||||||||||||||..||:||.|||.::.:||.:||::||:|.|
Human   253 ASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHF 317

  Fly   448 FTEVFTELKSCGQ 460
            ||:||.:||:.|:
Human   318 FTQVFQDLKNEGE 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5alpha	NP_001260320.1	CDK5_activator	107..458	CDD:281279	127/334 (38%)
CDK5R2	NP_003927.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..56		2/4 (50%)
		CDK5_activator	40..326	CDD:281279	125/332 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	72..98		9/65 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..175		7/60 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	329..367		1/2 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157423
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3932
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3382
Isobase	1	0.950	-	0	Normalized mean entropy	S4515
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1492547at2759
OrthoFinder	1	1.000	-	-		FOG0001633
OrthoInspector	1	1.000	-	-		otm40741
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23401
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1362
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.810