Protein Alignment Cdk5alpha and CDK5R2

DIOPT Version :8

• Sequence 1: NP_001260320.1
• Gene: Cdk5alpha / 34385
• FlyBaseID: FBgn0027491
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_003927.1
• Gene: CDK5R2 / 8941
• HGNCID: 1776
• Length: 367
• Species: Homo sapiens
• Alignment Length: 338
• Identity: 128/339 (38%)
• Similarity: 173/339 (51%)
• Gaps: 65/339 (19%)

  Fly   130 EKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHC 194
            |..||:.|:.|:||:||:|..:..||| :...|....|             ||:.
Human    51 ESRLKRPSVLISALTWKRLVAASAKKK-KGSKKVTPKP-------------ASTG---------- 91

  Fly   195 NRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMTGPPGKS--QNPS 257
                            |.|...|...:|. ..:.::........:.:...|.|.|...:  :.||
Human    92 ----------------PDPLVQQRNRENL-LRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPS 139

  Fly   258 ----KAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQASTSELL 318
                .|:.|.....|..                 |....|..:........||:.::||||.|||
Human   140 GGSAAAQPPGSGGGKPP-----------------PPPPPAPQVAPPVPGGSPRRVIVQASTGELL 187

  Fly   319 KCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELVSGEE- 382
            :|||.|:..||.||.....|:.|.|.|.||||||||||||.|||.|||:||||:|.||.:.|:|
Human   188 RCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDEL 252

  Fly   383 SKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKINAEPGF 447
            :..::|||:.||||||:||||||||||||||||||..||:||.|||.::.:||.:||::||:|.|
Human   253 ASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHF 317

  Fly   448 FTEVFTELKSCGQ 460
            ||:||.:||:.|:
Human   318 FTQVFQDLKNEGE 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5alpha	NP_001260320.1	CDK5_activator	107..458	CDD:281279	127/335 (38%)
CDK5R2	NP_003927.1	CDK5_activator	40..326	CDD:281279	126/333 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C9154343
eggNOG	1	0.900				E1_KOG3932
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3327
Isobase	1	0.950		0	Normalized mean entropy	S4515
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010				D1492547at2759
OrthoFinder	1	1.000				FOG0001317
OrthoInspector	1	1.000				T609539
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			O	PTHR23401
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	10	9.900