DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cdk5alpha and CDK5R2

DIOPT Version :10

Sequence 1:NP_523535.2 Gene:Cdk5alpha / 34385 FlyBaseID:FBgn0027491 Length:472 Species:Drosophila melanogaster
Sequence 2:NP_003927.1 Gene:CDK5R2 / 8941 HGNCID:1776 Length:367 Species:Homo sapiens


Alignment Length:338 Identity:128/338 - (37%)
Similarity:173/338 - (51%) Gaps:65/338 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 EKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHC 194
            |..||:.|:.|:||:||:|..:..||| :...|....|             ||:.          
Human    51 ESRLKRPSVLISALTWKRLVAASAKKK-KGSKKVTPKP-------------ASTG---------- 91

  Fly   195 NRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMTGPPGKS--QNPS 257
                            |.|...|...:|. ..:.::........:.:...|.|.|...:  :.||
Human    92 ----------------PDPLVQQRNRENL-LRKGRDPPDGGGTAKPLAVPVPTVPAAAATCEPPS 139

  Fly   258 ----KAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQASTSELL 318
                .|:.|.....|..                 |....|..:........||:.::||||.|||
Human   140 GGSAAAQPPGSGGGKPP-----------------PPPPPAPQVAPPVPGGSPRRVIVQASTGELL 187

  Fly   319 KCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELVSGEE- 382
            :|||.|:..||.||.....|:.|.|.|.||||||||||||.|||.|||:||||:|.||.:.|:| 
Human   188 RCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESLRGDEL 252

  Fly   383 SKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKINAEPGF 447
            :..::|||:.||||||:||||||||||||||||||..||:||.|||.::.:||.:||::||:|.|
Human   253 ASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLNADPHF 317

  Fly   448 FTEVFTELKSCGQ 460
            ||:||.:||:.|:
Human   318 FTQVFQDLKNEGE 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cdk5alphaNP_523535.2 CDK5_activator 96..461 CDD:460866 128/338 (38%)
CDK5R2NP_003927.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..56 2/4 (50%)
CDK5_activator 51..329 CDD:460866 127/335 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..98 9/65 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 131..175 7/60 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..367 1/2 (50%)

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