Protein Alignment Sur and Cftr

DIOPT Version :10

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_651269.1
• Gene: Cftr / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 2102
• Identity: 474/2102 - (22%)
• Similarity: 751/2102 - (35%)
• Gaps: 843/2102 - (40%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA----------------RSHYDHFLYIY 274
            |...|:..|.|..|||:.|.:..|..:||.|...||.:                |||
  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH-------- 72

  Fly   275 TEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYI------------ 327
             .||:|.:...:|:.|:                       :||..|..::.:|
  Fly    73 -RKKQKPHLRNALFRCF-----------------------LGPTIINGLICFIYIVIKTLIPAVL 113

  Fly   328 EQLYAQASEPPAKSPGN------EVANVLLSTSRIL-------------GTEFDEVFGTNIDK-- 371
            .||..|..:.|.....|      .:::.|..|:|.:             |:..|.:|..::||
  Fly   114 AQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAG 178

  Fly   372 ------------------VR-IYSST----WSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413
                              || |...|    |:|:.:.|   |.:||........|...... ..:
  Fly   179 PLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLG---AVLVLSTLFCCFLLHHVDLR-QRL 239

  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478
            .|.|::.:...|||||:|.|       |..:|||                   ||
  Fly   240 MGARMRIACCSLIYRKTLRL-------SMKTAGQ-------------------TP---------- 268

  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543
                .|.:.|.::.|...:...|:.:|:.|.:|.:..:..||:::|:||.|::|.:..::...|:
  Fly   269 ----AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329

  Fly   544 QFFIGNAMSKNAEV----IAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELK--- 601
            |    .|:||...|    ||..||.|:..:::.:.||:|||:.||::.|...:.||||.|:|
  Fly   330 Q----TALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR 390

  Fly   602 YLNKDATFWTLMAVLTHIATVLITFVT---LGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLL 663
            |.:....|:....|.|..:|:.||...   :|..:    ..:|..:|:..::.|.|     |..:
  Fly   391 YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTI----TADFVFSAASYYNILQL-----VAAI 446

  Fly   664 IFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTA 728
            .:|:.|.....|.||.||::.||
  Fly   447 WYPLAVSFGAEALVSLRRIQDFL------------------------------------------ 469

  Fly   729 QAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYV 793
                                      :|:..||..:.::....||.|
  Fly   470 --------------------------MLEGREERTQGLTHKRDQEGG------------------ 490

  Fly   794 AIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTW---QPQSQMPVV 855
                                                   |..||:|.|...:|   :||..:..:
  Fly   491 ---------------------------------------DSRAVTIKDINASWDIEKPQKTLQSI 516

  Fly   856 QLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTI 920
            .|.     :.||:|..|:|..|:||:|:|..||.|:|::.|.:|...  .:||.:|:|||...::
  Fly   517 NLQ-----IEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG--DLSYAAQEPWLFTGSV 574

  Fly   921 RENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSAN 985
            |.||||||.|..|||..|...|||..|.:.:|.||.:::||||.::|||||.||::|||:|..|.
  Fly   575 RNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQ 639

  Fly   986 VVIMDDPLASLDNEVGEHIFQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACG 1048
            :.:|||||:::|..||.|:|...|  |..|.:...|.||||.|:|.:.||:.::.:..||:...|
  Fly   640 IYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQG 704

  Fly  1049 SYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDAN 1113
            :|.::      |.::.:....:.:.|.:...:|...:|:                 .:||
  Fly   705 TYQEL------INSDLDFARLLERPKEEEEGENSRNQTS-----------------PLSV----- 741

  Fly  1114 VACHADAIDGSGCISVANMQSNVVEEDDQVSVSYP-IGNASCGGFNLQRKRSSIYGSRHLMYDVP 1177
                                 |.:|.||:   ..| |.....|...|:::.||::||:.|
  Fly   742 ---------------------NSLESDDE---DIPFIDGVKDGYQQLRKQSSSVHGSKSL----- 777

  Fly  1178 LPIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCS 1242
               |..|.||
  Fly   778 ---DSTQLDD------------------------------------------------------- 784

  Fly  1243 SYAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTS 1307
                 :||..|||                                            ||:.|...
  Fly   785 -----NVDEDDLA--------------------------------------------EAQASGGI 800

  Fly  1308 SESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNK 1372
            |                          |:..:....|.:::||.|        |...::..
  Fly   801 S--------------------------PRVWYEYFHAGSTLLSFS--------FMVFVMVM---- 827

  Fly  1373 NETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGR 1437
                               :.:.|       |..:..||:.:    |::|
  Fly   828 -------------------SQVVC-------SSSDFFANIWT----QQEH--------------- 847

  Fly  1438 ESMPLARLAIDTERKYGKISDDIY-LMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVH 1501
                        :|..|:.:...: .|||  .|..||.:..:|..
  Fly   848 ------------QRSQGEATFSTFECMYI--YGALIIAVVIMTTF-------------------- 878

  Fly  1502 GRVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTIL 1566
                 :|.:             :|:       :|:               :|.:.|||::...||
  Fly   879 -----RGFL-------------FFK-------ICM---------------HASKVLHDRMFACIL 903

  Fly  1567 HKTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPI 1631
            |.|:.||..||.|||:||||.||..||:.:.......:|..|:....:::...:.|.::...|.:
  Fly   904 HATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVV 968

  Fly  1632 CGAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL----E 1692
            .....||.|.|...:::|:|:|....|||.||||.::.|:..||:...|    :::.|..    :
  Fly   969 AVVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQ----DVVAKEFDLLQD 1029

  Fly  1693 ANTIAYALLNTSHRWLGVSLDYLGGCI--VFVATVTALTAASVSCRRHYEATTSPSASASPSPFE 1755
            .::..:.|....:..||:.||    |:  :|:.:||.....|      .|.|.|.:
  Fly  1030 VHSSVWQLTMAVNTTLGLWLD----CVSCIFLTSVTFSFIIS------SETTYSGN--------- 1075

  Fly  1756 TYAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADA 1820
                             |||||...:::...:.:.|:.:|:......||||:..|
  Fly  1076 -----------------VGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQY---------- 1113

  Fly  1821 DADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGG 1885
                     .:|:.||:..|
  Fly  1114 ---------TELEQEPALGE--------------------------------------------- 1124

  Fly  1886 GDCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQD 1950
                                                              ||        ||||
  Fly  1125 --------------------------------------------------KT--------PPQQ- 1130

  Fly  1951 DKDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGIC 2015
                                     ||.||.:.|.|:|.||:.....|:.||.|.|.||.::||.
  Fly  1131 -------------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIV 1170

  Fly  2016 GRTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPH 2080
            ||||:|||||..:||. |....|.|:||.::...|..:.||||:||||||..||:||||.||||.
  Fly  1171 GRTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPF 1234

  Fly  2081 GYFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDE 2145
            ..:.|.:||:.||..:|::.:.     |||.::.:.|.|.|.|.||||||||||||.:..|||||
  Fly  1235 ERYTDAELWSALEDVELRKAIP-----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDE 1294

  Fly  2146 ATSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVE-----------DG 2199
            ||:.:|..|::.:.:...:.|:..|::|:||||.|::|.||:||:|.|..||           .|
  Fly  1295 ATANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQG 1359

  Fly  2200 NPRELQQLEGSVFRGLLEKGAS 2221
            :.|::.:..|..... |:|.||
  Fly  1360 HLRQMVEATGGESEA-LKKTAS 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	ABC_6TM_SUR1_D1_like	301..682	CDD:350035	101/446 (23%)
		TM helix 1	301..324	CDD:350035	3/22 (14%)
		TM helix 2	385..433	CDD:350035	13/47 (28%)
		TM helix 3	480..525	CDD:350035	9/44 (20%)
		TM helix 4	526..575	CDD:350035	15/52 (29%)
		TM helix 5	587..631	CDD:350035	14/49 (29%)
		TM helix 6	648..681	CDD:350035	8/32 (25%)
		ABCC_MRP_domain1	837..1043	CDD:213217	86/210 (41%)
		ABC_6TM_SUR1_D2_like	1475..1811	CDD:350046	74/341 (22%)
		TM helix 1	1475..1496	CDD:350046	1/20 (5%)
		TM helix 2	1520..1568	CDD:350046	8/47 (17%)
		TM helix 3	1575..1620	CDD:350046	15/44 (34%)
		TM helix 4	1621..1670	CDD:350046	16/48 (33%)
		TM helix 5	1682..1727	CDD:350046	9/50 (18%)
		TM helix 6	1777..1810	CDD:350046	7/32 (22%)
		ABCC_MRP_domain2	1980..2201	CDD:213211	104/231 (45%)
Cftr	NP_651269.1	MRP_assoc_pro	12..1356	CDD:188098	467/2075 (23%)