Protein Alignment Sur and CG5789

DIOPT Version :9

• Sequence 1: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Sequence 2: NP_001247286.1
• Gene: CG5789 / 42928
• FlyBaseID: FBgn0039207
• Length: 1402
• Species: Drosophila melanogaster
• Alignment Length: 2101
• Identity: 473/2101 - (22%)
• Similarity: 752/2101 - (35%)
• Gaps: 841/2101 - (40%)

  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSA----------------RSHYDHFLYIY 274
            |...|:..|.|..|||:.|.:..|..:||.|...||.:                |||
  Fly    16 ANIISQLIFAWAIPLLYRGSRRGLNTDDLTQCLKEDRSEQLGDRLEDQWFKELERSH-------- 72

  Fly   275 TEKKKKSNSSPSLWYCYIKNSWQMFALGGILKLAGDLFALIGPLAIQKIVEYI------------ 327
             .||:|.:...:|:.|:                       :||..|..::.:|
  Fly    73 -RKKQKPHLRNALFRCF-----------------------LGPTIINGLICFIYIVIKTLIPAVL 113

  Fly   328 EQLYAQASEPPAKSPGN------EVANVLLSTSRIL-------------GTEFDEVFGTNIDK-- 371
            .||..|..:.|.....|      .:::.|..|:|.:             |:..|.:|..::||
  Fly   114 AQLLIQFQKTPVAQLRNIDVNDISISDSLNRTARAIPNYVLSQAVANSSGSPGDALFPKSLDKAG 178

  Fly   372 ------------------VR-IYSST----WSDLLANGWCIAWIVLLAAITQGALSQASTHILNM 413
                              || |...|    |:|:.:.|   |.:||........|...... ..:
  Fly   179 PLEPIQPPVEEVDHNATAVRSILDQTVEHMWNDMNSLG---AVLVLSTLFCCFLLHHVDLR-QRL 239

  Fly   414 TGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPSEPN 478
            .|.|::.:...|||||:|.|       |..:|||                   ||
  Fly   240 MGARMRIACCSLIYRKTLRL-------SMKTAGQ-------------------TP---------- 268

  Fly   479 ISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIMTPL 543
                .|.:.|.::.|...:...|:.:|:.|.:|.:..:..||:::|:||.|::|.:..::...|:
  Fly   269 ----AGYLINLLSNDVNRLDYGFIFMHWIWIMPLQAMLTCYLIWLNIGIPAIVGVVGLLLKTVPV 329

  Fly   544 QFFIGNAMSKNAEV----IAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELK--- 601
            |    .|:||...|    ||..||.|:..:::.:.||:|||:.||::.|...:.||||.|:|
  Fly   330 Q----TALSKVTSVLRMRIAERTDARVGIMNELVQGIQVIKMYAWEKPFQAVVAEARRSEIKQIR 390

  Fly   602 YLNKDATFWTLMAVLTHIATVLITFVT---LGVYVWLHRDQEFDLNASRLFSSLALFQQLTVPLL 663
            |.:....|:....|.|..:|:.||...   :|..:    ..:|..:|:..::.|.|     |..:
  Fly   391 YASYLRGFYLSTMVFTERSTLYITLAAAALMGQTI----TADFVFSAASYYNILQL-----VAAI 446

  Fly   664 IFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRTA 728
            .:|:.|.....|.||.||::.||
  Fly   447 WYPLAVSFGAEALVSLRRIQDFL------------------------------------------ 469

  Fly   729 QAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPYV 793
                                      :|:..||..:.::....||.|
  Fly   470 --------------------------MLEGREERTQGLTHKRDQEGG------------------ 490

  Fly   794 AIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTW---QPQSQMPVV 855
                                                   |..||:|.|...:|   :||..:..:
  Fly   491 ---------------------------------------DSRAVTIKDINASWDIEKPQKTLQSI 516

  Fly   856 QLHVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTI 920
            .|.     :.||:|..|:|..|:||:|:|..||.|:|::.|.:|...  .:||.:|:|||...::
  Fly   517 NLQ-----IEKGQLCAVIGPVGAGKSSILQLLLGELPVIDGGVFIQG--DLSYAAQEPWLFTGSV 574

  Fly   921 RENILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSAN 985
            |.||||||.|..|||..|...|||..|.:.:|.||.:::||||.::|||||.||::|||:|..|.
  Fly   575 RNNILFGEEFDRKRYQEVTRCCALSTDFQQLPNGDKTLVGERGASLSGGQRARISLARAVYKPAQ 639

  Fly   986 VVIMDDPLASLDNEVGEHIFQHCI--REMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACG 1048
            :.:|||||:::|..||.|:|...|  |..|.:...|.||||.|:|.:.||:.::.:..||:...|
  Fly   640 IYLMDDPLSAVDAHVGRHLFDEVIGPRGRLAQLKATRILVTHQVHFLSEADVIVIVDQGRILRQG 704

  Fly  1049 SYADIELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDAN 1113
            :|.::      |.::.:....:.:.|.:...:|...:|:                 .:||
  Fly   705 TYQEL------INSDLDFARLLERPKEEEEGENSRNQTS-----------------PLSV----- 741

  Fly  1114 VACHADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPL 1178
                                 |.:|.||: .:.: |.....|...|:::.||::||:.|
  Fly   742 ---------------------NSLESDDE-DIPF-IDGVKDGYQQLRKQSSSVHGSKSL------ 777

  Fly  1179 PIDECQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSS 1243
              |..|.||
  Fly   778 --DSTQLDD-------------------------------------------------------- 784

  Fly  1244 YAESSVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSS 1308
                :||..|||                                            ||:.|...|
  Fly   785 ----NVDEDDLA--------------------------------------------EAQASGGIS 801

  Fly  1309 ESPLDDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKN 1373
                                      |:..:....|.:::||.|        |...::..
  Fly   802 --------------------------PRVWYEYFHAGSTLLSFS--------FMVFVMVM----- 827

  Fly  1374 ETQSEEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRE 1438
                              :.:.|       |..:..||:.:    |::|
  Fly   828 ------------------SQVVC-------SSSDFFANIWT----QQEH---------------- 847

  Fly  1439 SMPLARLAIDTERKYGKISDDIY-LMYIRAAGLPIITIFFITALIWQCLRVYTDIWLQQWSNVHG 1502
                       :|..|:.:...: .|||  .|..||.:..:|..
  Fly   848 -----------QRSQGEATFSTFECMYI--YGALIIAVVIMTTF--------------------- 878

  Fly  1503 RVASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILH 1567
                :|.:             :|:       :|:               :|.:.|||::...|||
  Fly   879 ----RGFL-------------FFK-------ICM---------------HASKVLHDRMFACILH 904

  Fly  1568 KTLHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTITPWILVLTLPIC 1632
            .|:.||..||.|||:||||.||..||:.:.......:|..|:....:::...:.|.::...|.:.
  Fly   905 ATMRFFDTTPSGRILNRFSKDMGAIDELLPRAMMDFIQIALVMFGILIVIGILNPVLVAAMLVVA 969

  Fly  1633 GAYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRL----EA 1693
            ....||.|.|...:::|:|:|....|||.||||.::.|:..||:...|    :::.|..    :.
  Fly   970 VVDVLILKLYLRPSQDLKRLEGICRSPVFSHLSASLTGLAIIRSRQLQ----DVVAKEFDLLQDV 1030

  Fly  1694 NTIAYALLNTSHRWLGVSLDYLGGCI--VFVATVTALTAASVSCRRHYEATTSPSASASPSPFET 1756
            ::..:.|....:..||:.||    |:  :|:.:||.....|      .|.|.|.:
  Fly  1031 HSSVWQLTMAVNTTLGLWLD----CVSCIFLTSVTFSFIIS------SETTYSGN---------- 1075

  Fly  1757 YAVTKSPSELRPSPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADAD 1821
                            |||||...:::...:.:.|:.:|:......||||:..|
  Fly  1076 ----------------VGLAIAQAMILTGMVQYGVRQVAESLQQMTSVERVLQY----------- 1113

  Fly  1822 ADADADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGG 1886
                    .:|:.||:..|
  Fly  1114 --------TELEQEPALGE---------------------------------------------- 1124

  Fly  1887 DCGYRQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDD 1951
                                                             ||        ||||
  Fly  1125 -------------------------------------------------KT--------PPQQ-- 1130

  Fly  1952 KDKKVVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRYEGQKQNVISNLTLKIPAGQRIGICG 2016
                                    ||.||.:.|.|:|.||:.....|:.||.|.|.||.::||.|
  Fly  1131 ------------------------WPTRGQVEFRNMSCRYDPNGSPVLRNLNLTIEAGWKVGIVG 1171

  Fly  2017 RTGSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHG 2081
            |||:|||||..:||. |....|.|:||.::...|..:.||||:||||||..||:||||.||||..
  Fly  1172 RTGAGKSSLIGALFR-LAHIEGEIFIDGIETGTISLEILRTRISIIPQDPVLFSATIRYNLDPFE 1235

  Fly  2082 YFQDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEA 2146
            .:.|.:||:.||..:|::.:.     |||.::.:.|.|.|.|.||||||||||||.:..||||||
  Fly  1236 RYTDAELWSALEDVELRKAIP-----GLDYMVTERGGNFSVGQRQLLCLARAILRNNKVLVLDEA 1295

  Fly  2147 TSVLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVE-----------DGN 2200
            |:.:|..|::.:.:...:.|:..|::|:||||.|::|.||:||:|.|..||           .|:
  Fly  1296 TANVDPQTDALIQRTIRIKFKQCTVLTVAHRLHTVMDSDRIIVMDAGVAVEFDVPYLLLKKSQGH 1360

  Fly  2201 PRELQQLEGSVFRGLLEKGAS 2221
            .|::.:..|..... |:|.||
  Fly  1361 LRQMVEATGGESEA-LKKTAS 1380

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sur	NP_001334732.1	None
CG5789	NP_001247286.1	CFTR_protein	9..1367	CDD:273530	468/2085 (22%)
		ABC_membrane	214..441	CDD:294371	69/278 (25%)
		ABCC_MRP_domain1	495..699	CDD:213217	86/210 (41%)
		ABC_membrane	863..1088	CDD:294371	73/326 (22%)
		ABCC_MRP_domain2	1135..1350	CDD:213211	103/220 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160